Head of the Group

Prof. Dr.-Ing. Udo Reichl
Prof. Dr.-Ing. Udo Reichl
Phone: +49 391 6110 201
Fax: +49 391 6110 203

Contact Person

Annegret Frauendienst
Phone: +49 391 6110 200
Fax: +49 391 6110 203

Group Page

Publications

Publications BPE group

Journal Article (202)

  1. 2012
    Carrondo, M. J. T.; Alves, P. M.; Carinhas, N.; Glassey, J.; Hesse, F.; Merten, O.-W.; Micheletti, M.; Noll, T.; Oliveira, R.; Reichl, U. et al.; Staby, A.; Teixeira, A. P.; Weichert, H.; Mandenius, C.-F.: How can measurement, monitoring, modeling and control advance cell culture in industrial biotechnology? Biotechnology Journal 7 (12), pp. 1522 - 1529 (2012)
  2. Hanreich, A.; Heyer, R.; Benndorf, D.; Rapp, E.; Pioch, M.; Reichl, U.; Klocke, M.: Metaproteome analysis to determine the metabolically active part of thermophilic microbial community producing biogas from agricultural biomass. Canadian Journal of Microbiology 58 (7), pp. 917 - 922 (2012)
  3. Heldt, F. S.; Frensing, T.; Reichl, U.: Modeling the intracellular dynamics of influenza virus replication to understand the control of viral RNA synthesis. Journal of Virology 86 (15), pp. 7806 - 7817 (2012)
  4. Isken, B.; Genzel, Y.; Reichl, U.: Productivity, apoptosis, and infection dynamics of influenza A/PR/8 strains and A/PR/8-based reassortants. Vaccine 30 (35), pp. 5253 - 5261 (2012)
  5. Kluge, S.; Hoffmann, M.; Benndorf, D.; Rapp, E.; Reichl, U.: Proteomic tracking and analysis of a bacterial mixed culture. Proteomics 12 (12), pp. 1893 - 1901 (2012)
  6. Kolmakov, K.; Wurm, C.; Hennig, R.; Rapp, E.; Jakobs, S.; Belov, V. N.; Hell, S. W.: Red-Emitting Rhodamines with Hydroxylated, Sulfonated, and Phosphorylated Dye Residues and Their Use in Fluorescence Nanoscopy. Chemistry - A European Journal 18 (41), pp. 12986 - 12998 (2012)
  7. Lohr, V.; Genzel, Y.; Jordan, I.; Katinger, D.; Mahr, S.; Sandig, V.; Reichl, U.: Live attenuated influenza viruses produced in a suspension process with avian AGE1.CR.pIX cells. BMC Biotechnology 12, p. 79 (2012)
  8. Muth, T.; Garcia-Martin, J. A.; Rausell, A.; Juan, D.; Valencia, A.; Pazos, F.: JDet: interactive calculation and visualization of function-related conservation patterns in multiple sequence alignments and structures. Bioinformatics 28 (4), pp. 584 - 586 (2012)
  9. Platas Barradas, O.; Jandt, U.; Da Minh Phan, L.; Villanueva, M. E.; Schaletzky, M.; Rath, A.; Freund, S.; Reichl, U.; Skerhutt, E.; Scholz, S. et al.; Noll, T.; Sandig, V.; Pörtner, R.; Zeng, A.-P.: Evaluation of criteria for bioreactor comparison and operation standardization for mammalian cell culture. Engineering in Life Sciences 12 (5), pp. 518 - 528 (2012)
  10. Popov, M.; Nacheva, G.; Reichl, U.; Ivanov, I.: Effect of the 3’-terminal truncation of the human interferon-gamma gene on plasmid segregation in escherichia coli. Biotechnology and Biotechnological Equipment 26 (2), pp. 2930 - 2936 (2012)
  11. Rapp, E.; Borowiak, M.: Limonade durch Fermentation. Chemie in unserer Zeit 46 (1), pp. 60 - 61 (2012)
  12. Riedele, C.; Reichl, U.: Time-kill studies with a ceftazidime-treated mixed culture consisting of Pseudomonas aeruginosa, Burkholderia cepacia and Staphylococcus aureus. Engineering in Life Sciences 12 (2), pp. 188 - 197 (2012)
  13. Rüger, M.; Bensch, G.; Tüngler, R.; Reichl, U.: A Flow Cytometric Method for Viability Assessment of Staphylococcus aureus and Burkholderia cepacia in Mixed Culture. Cytometry Part A 81 A (12), pp. 1055 - 1066 (2012)
  14. Seitz, C.; Isken, B.; Heynisch, B.; Rettkowski, M.; Frensing, T.; Reichl, U.: Trypsin promotes efficient influenza vaccine production in MDCK cells by interfering with the antiviral host response. Applied Microbiology and Biotechnology 93 (2), pp. 601 - 611 (2012)
  15. Selman, M. H. J.; Hoffmann, M.; Zauner, G.; McDonnell, L. A.; Balog, C. I. A.; Rapp, E.; Deelder, A. M.; Wuhrer, M.: MALDI-TOF-MS analysis of sialylated glycans and glycopeptides using 4-chloro-α-cyanocinnamic acid matrix. Proteomics 12 (9), pp. 1337 - 1348 (2012)
  16. Zauner, G.; Hoffmann, M.; Rapp, E.; Koeleman, C. A. M.; Dragan, I.; Deelder, A. M.; Wuhrer, M.; Hensbergen, P. J.: Glycoproteomic Analysis of Human Fibrinogen Reveals Novel Regions of O‑Glycosylation. Journal of Proteome Research 11 (12), pp. 5804 - 5814 (2012)
  17. 2011
    Bock, A.; Schulze-Horsel, J.; Schwarzer, J.; Rapp, E.; Genzel, Y.; Reichl, U.: High-density microcarrier cell cultures for influenza virus production. Biotechnology Progress 27 (1), pp. 241 - 250 (2011)
  18. Frensing, T.; Seitz, C.; Heynisch, B.; Patzina, C.; Kochs, G.; Reichl, U.: Efficient influenza B virus propagation due to deficient interferon-induced antiviral activity in MDCK cells. Vaccine 29 (41), pp. 7125 - 7129 (2011)
  19. Janke, R.; Genzel, Y.; Händel, N.; Wahl, A.; Reichl, U.: Metabolic adaptation of MDCK cells to different growth conditions: Effects on catalytic activities of central metabolic enzymes. Biotechnology and Bioengineering 108 (11), pp. 2691 - 2704 (2011)
  20. Kalmbach, A.; Bordas, R.; Öncül, A.; Thévenin, D.; Genzel, Y.; Reichl, U.: Experimental Characterization of Flow Conditions in 2- and 20-L Bioreactors with Wave-Induced Motion. Biotechnology Progress 27 (2), pp. 402 - 409 (2011)
  21. Kolvenbach, B. A.; Lenz, M.; Benndorf, D.; Rapp, E.; Fousek, J.; Vlcek, C.; Schäffer, A.; Gabriel, F. L.; Kohler, H.-P. E.; Corvini, P. F.: Purification and characterization of hydroquinone dioxygenase from Sphingomonas sp. strain TTNP3. AMB Express 1, p. 8 (2011)
  22. Kuhn, R.; Benndorf, D.; Rapp, E.; Reichl, U.; Palese, L.; Pollice, A.: Metaproteome analysis of sewage sludge from membrane bioreactors. Proteomics 11 (13), pp. 2738 - 2744 (2011)
  23. Petiot, E.; Jacob, D.; Lanthier, S.; Lohr, V.; Ansorge, S.; Kamen, A. A.: Metabolic and Kinetic analyses of influenza production in perfusion HEK293 cell culture. BMC Biotechnology 11 (84), pp. 1 - 12 (2011)
  24. Popov, M.; Petrov, S. A.; Nacheva, G.; Ivanov, I.; Reichl, U.: Effects of a recombinant gene expression on ColE1-like plasmid segregation in Escherichia coli. BMC Biotechnology 11 (1), p. 18 (2011)
  25. Riedele, C.; Reichl, U.: Inter-Species Effects in Ceftazidime-Treated Mixed Culture of Pseudomonas aeruginosa, Burkholderia cepacia and Staphylococcus aureus – Analysis on the Single Species Level. Journal of Antimicrobial Chemotherapy 66 (1), pp. 138 - 145 (2011)
  26. Roedig, J.; Rapp, E.; Höper, D.; Genzel, Y.; Reichl, U.: Impact of Host Cell Line Adaptation on Quasispecies Composition and Glycosylation of Influenza A Virus Hemagglutinin. PLoS One 6 (12), p. e27989 (2011)
  27. Rödig, J.; Rapp, E.; Djeljadini, S.; Lohr, V.; Genzel, Y.; Jordan, I.; Sandig, V.; Reichl, U.: Impact of Influenza Virus Adaptation Status on HA N-Glycosylation Patterns in Cell Culture-Based Vaccine Production. Journal of Carbohydrate Chemistry 30 (4-6), pp. 281 - 290 (2011)
  28. Schmidt, J. K.; Riedele, C.; Regestein, L.; Rausenberger, J.; Reichl, U.: A novel concept combining experimental and mathematical analysis for the identification of unknown interspecies effects in a mixed culture. Biotechnology and Bioengineering 108 (8), pp. 1900 - 1911 (2011)
  29. Wolff, M.; Reichl, U.: Downstream processing of cell culture-derived virus particles. Expert Review of Vaccines 10 (10), pp. 1451 - 1475 (2011)
  30. 2010
    Benndorf, D.; Jach, M.; Klamt, S.; Reichl, U.: Systembiologie-Ausbildung von Anfang an. Systembiologie.de (2), pp. 82 - 84 (2010)
  31. Domann, P. J.; Akashi, S.; Barbas, C.; Huang, L.; Lau, W.; Legido-Quigley, C.; McClean, S.; Neusüß, C.; Perrett, D.; Quaglia, M. et al.; Rapp, E.; Smallshaw, L.; Smith, N. W.; Smyth, W. F.; Taylor, C. F.: Guidelines for reporting the use of capillary electrophoresis in proteomics. Nature biotechnology 28 (7), pp. 654 - 655 (2010)
  32. Genzel, Y.; Dietzsch, C.; Rapp, E.; Schwarzer, J.; Reichl, U.: MDCK and Vero cells for influenza virus vaccine production: a one-to-one comparison up to lab-scale bioreactor cultivation. Applied Microbiology and Biotechnology 88 (2), pp. 461 - 475 (2010)
  33. Heynisch, B.; Frensing, T.; Heinze, K.; Seitz, C.; Genzel, Y.; Reichl, U.: Differential activation of host cell signaling pathways through infection with two variants of influenza A /Puerto Rico /8/34 (H1N1) in MDCK cells. Vaccine 28 (51), pp. 8210 - 8218 (2010)
  34. Janke, R.; Genzel, Y.; Wahl, A.; Reichl, U.: Measurement of Key Metabolic Enzyme Activities in Mammalian Cells Using Rapid and Sensitive Microplate-Based Assays. Biotechnology and Bioengineering 107 (3), pp. 566 - 581 (2010)
  35. Janke, R.; Genzel, Y.; Freund, S.; Wolff, M. W.; Grammel, H.; Rühmkorf, C.; Seidemann, J.; Wahl, A.; Reichl, U.: Expression, purification, and characterization of a His6-tagged glycerokinase from Pichia farinosa for enzymatic cycling assays in mammalian cells. Journal of Biotechnology 150 (3), pp. 396 - 403 (2010)
  36. Kröber, T.; Knöchlein, A.; Eisold, K.; Kalbfuß-Zimmermann, B.; Reichl, U.: DNA Depletion by Precipitation in the Purification of Cell Culture-Derived Influenza Vaccines. Chemical Engineering and Technology 33 (6), pp. 941 - 959 (2010)
  37. Lohr, V.; Genzel, Y.; Behrendt, I.; Scharfenberg, K.; Reichl, U.: A new MDCK suspension line cultivated in a fully defined medium in stirred-tank and wave bioreactor. Vaccine 28 (38), pp. 6256 - 6264 (2010)
  38. Ritter, J.; Wahl, A.; Freund, S.; Genzel, Y.; Reichl, U.: Metabolic effects of influenza virus infection in cultured animal cells: Intra- and extracellular metabolite profiling. BMC Systems Biology 4, p. 61 (2010)
  39. Rollié, S.; Lendeckel, U.; Naumann, M.; Reichl, U.; Sundmacher, K.: Dynamics of bionanoparticle targeting in mixtures of human tumour cells by validated population balance modelling. Soft Matter 6 (6), pp. 1203 - 1216 (2010)
  40. Roma-Rodriguesa, C.; Santosa, P.; Benndorf, D.; Rapp, E.; Sá-Correiaa, I.: Response of Pseudomonas putida KT2440 to phenol at the level of membrane proteome. Proteomics 73 (8), pp. 1461 - 1478 (2010)
  41. Ruhaak, L.E.; Hennig, R.; Huhn, C.; Borowiak, M.; Dolhain, R.J.E.M.; Deelder, A.; Rapp, E.; Wuhrer, M.: Optimized Workflow for Preparation of APTS-Labeled N-Glycans Allowing High-Throughput Analysis of Human Plasma Glycomes using 48-Channel Multiplexed CGE-LIF. Journal of Proteome Research 9 (12), pp. 6655 - 6664 (2010)
  42. Seitz, C.; Frensing, T.; Höper, D.; Kochs, G.; Reichl, U.: High yields of Influenza A virus in MDCK cells are promoted by an insufficient IFN-induced antiviral state. Journal of General Virology 91 (7), pp. 1754 - 1763 (2010)
  43. Vester, D.; Rapp, E.; Kluge, S.; Genzel, Y.; Reichl, U.: Virus-host cell interactions in vaccine production cell lines infected with different human influenza A virus variants: A proteomic approach. Journal of Proteomics 73 (9), pp. 1656 - 1669 (2010)
  44. Vester, D.; Pflugmacher, A.; Hoffmann, D.; Seitz, C.; Heldt, S.; Bettenbrock, K.; Genzel, Y.; Reichl, U.: Real-time RT-qPCR assay for the analysis of human influenza A virus transcription and replication dynamics. Journal of Virological Methods 168 (1-2), pp. 63 - 71 (2010)
  45. Wolff, M.; Siewert, C.; Lehmann, S.; Hansen, S.P.; Djurup, R.; Faber, R.; Reichl, U.: Capturing of Cell Culture-Derived Modified Vaccinia Ankara Virus by Ion Exchange and Pseudo-Affinity Membrane Adsorbers. Biotechnology and Bioengineering 105 (4), pp. 761 - 769 (2010)
  46. Wolff, M.; Siewert, C.; Hansen, S. P.; Faber, R.; Reichl, U.: Purification of cell culture-derived modified Vaccinia Ankara virus by pseudo-affinity membrane adsorbers and hydrophobic interaction chromatography. Biotechnology and Bioengineering 107 (2), pp. 312 - 320 (2010)
  47. Öncül, A.; Kalmbach, A.; Genzel, Y.; Reichl, U.; Thevenin, D.: Characterization of flow conditions in 2 L and 20 L wave bioreactors using Computational Fluid Dynamics. Biotechnology Progress 26 (1), pp. 101 - 110 (2010)
  48. 2009
    Bock, A.; Möhler, L.; Sann, H.; Schulze-Horsel, J.; Genzel, Y.; Reichl, U.: Growth behaviour of number distributed adherent MDCK cells for optimization in large scale microcarrier cultures. Biotechnology Progress 25 (6), pp. 1717 - 1731 (2009)
  49. Genzel, Y.; Reichl, U.: Continuous cell lines as production system for influenza vaccines. Expert Review of Vaccines 8 (12), pp. 1681 - 1692 (2009)
  50. Lohr, V.; Rath, A.; Genzel, Y.; Jordan, I.; Sandig, V.; Reichl, U.: New avian suspension cell lines provide production of influenza virus and MVA in serum-free media: studies on growth, metabolism and virus propagation. Vaccine 27 (36), pp. 4975 - 4982 (2009)
 
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