Head of the Group

Prof. Dr.-Ing. Udo Reichl
Prof. Dr.-Ing. Udo Reichl
Phone: +49 391 6110 201
Fax: +49 391 6110 203
Room: N0.19

Contact Person

Annegret Frauendienst
Phone: +49 391 6110 200
Fax: +49 391 6110 203
Room: N0.20

Group Page


Publications BPE group

Journal Article (206)

  1. 2015
    Kohrs, F.; Wolter, S.; Benndorf, D.; Heyer, R.; Hoffmann, M.; Rapp, E.; Bremges, A.; Sczyrba, A.; Schlüter, A.; Reichl, U.: Fractionation of biogas plant sludge material improves metaproteomic characterization to investigate metabolic activity of microbial communities. Proteomics 15 (20), pp. 3585 - 3589 (2015)
  2. Kolmeder , C.; Ritari, J.; Verdam , F.; Muth, T.; Keskitalo, S.; Varjosalo , M.; Fuentes, S.; Greve , J.; Buurman , W.; Reichl, U. et al.; Rapp, E.; Martens, L.; Palva, A.; Salonen, A.; Rensen, S.; de Vos, W.: Colonic metaproteomic signatures of active bacteria and the host in obesity. Proteomics 15 (20), pp. 3544 - 3552 (2015)
  3. Muth, T.; Behne, A.; Heyer, R.; Kohrs, F.; Benndorf, D.; Hoffmann, M.; Lehteva, M.; Reichl, U.; Martens, L.; Rapp, E.: The MetaProteomeAnalyzer: A Powerful Open-Source Software Suite for Metaproteomics Data Analysis and Interpretation. Journal of Proteome Research 14 (3), pp. 1557 - 1565 (2015)
  4. Muth, T.; Kolmeder, C. A.; Salojärvi, J.; Keskitalo, S.; Varjosalo, M.; Verdam, F. J.; Rensen, S. S.; Reichl, U.; de Vos, W. M.; Rapp, E. et al.; Martens, L.: Navigating through metaproteomics data: A logbook of database searching. Proteomics 15 (20), pp. 3439 - 3453 (2015)
  5. Oveland, E.; Muth, T.; Rapp, E.; Martens, L.; Berven, F. S.; Barsnes, H.: Viewing the proteome: How to visualize proteomics data? Proteomics 15 (8), pp. 1341 - 1355 (2015)
  6. Püttker, S.; Kohrs, F.; Benndorf, D.; Heyer, R.; Rapp, E.; Reichl, U.: Metaproteomics of activated sludge from a wastewater treatment plant- a pilot study. Proteomics 15 (20), pp. 3596 - 3601 (2015)
  7. Serve, A.; Pieler, M.; Benndorf, D.; Rapp, E.; Wolff, M. W.; Reichl, U.: Comparison of Influenza Virus Particle Purification Using Magnetic Sulfated Cellulose Particles with an Established Centrifugation Method for Analytics. Analytical Chemistry 87 (21), pp. 10708 - 10711 (2015)
  8. Theuerl, S.; Kohrs, F.; Benndorf, D.; Maus, I.; Wibberg, D.; Schlüter, A.; Kausmann, R.; Heiermann, M.; Rapp, E.; Reichl, U. et al.; Pühler, A.; Klocke, M.: Community shifts in a well-operating agricultural biogas plant: how process variations are handled by the microbiome. Applied Microbiology and Biotechnology 99 (18), pp. 7791 - 7803 (2015)
  9. 2014
    Benndorf, D.; Reichl, U.: Proteomics in environmental and technical microbiology. Engineering in Life Sciences 14 (1), pp. 27 - 46 (2014)
  10. Bensch, G.; Rüger, M.; Wassermann, M.; Weinholz, S.; Reichl, U.; Cordes, C.: Flow cytometric viability assessment of lactic acid bacteria starter cultures produced by fluidized bed drying. Applied Microbiology and Biotechnology 98 (11), pp. 4897 - 4909 (2014)
  11. Bensmann, A.; Hanke-Rauschenbach, R.; Heyer, R.; Kohrs, F.; Benndorf, D.; Reichl, U.; Sundmacher, K.: Biological methanation of hydrogen within biogas plants: A model-based feasibility study. Applied Energy 134, pp. 413 - 425 (2014)
  12. Diba, M.; Goudouri, O.-M.; Tapia, F.; Boccaccini, A. R.: Magnesium-containing bioactive polycrystalline silicate-based ceramics and glass-ceramics for biomedical applications. Current Opinion in solid state & materials science 18 (3), pp. 147 - 167 (2014)
  13. Frensing, T.; Pflugmacher, A.; Bachmann, M.; Peschel, B.; Reichl, U.: Impact of defective interfering particles on virus replication and antiviral host response in cell culture-based influenza vaccine production. Applied Microbiology and Biotechnology 98 (21), pp. 8999 - 9008 (2014)
  14. Genzel, Y.; Vogel, T.; Buck, J.; Behrendt, I.; Vazquez-Ramirez, D.; Schiedner, G.; Jordan, I.; Reichl, U.: High cell density cultivations by alternating tangential flow (ATF) perfusion for influenza A virus production using suspension cells. Vaccine 32 (24), pp. 2770 - 2781 (2014)
  15. Huffman, J. E.; Pucic-Bakovic, M.; Klaric, L.; Hennig, R.; Selman, M. H.J.; Vuckovic, F.; Novokmet, M.; Kristic, J.; Borowiak, M.; Muth, T. et al.; Polasek, O.; Razdorov, G.; Gornik, O.; Plomp, R.; Theodorarou, E.; Wright, A. F.; Rudan, I.; Hayward, C.; Campbell, H.; Deelder, A. M.; Reichl, U.; Aulchenko, Y. S.; Rapp, E.; Wuhrer , M.; Lauc , G.: Comparative Performance of Four Methods for High-throughput Glycosylation Analysis of Immunoglobulin G in Genetic and Epidemiological Research. Molecular and Cellular Proteomics 13 (6), pp. 1598 - 1610 (2014)
  16. Kohrs, F.; Heyer, R.; Magnussen, A.; Benndorf, D.; Muth, T.; Behne, A.; Rapp, E.; Kausmann, R.; Heiermann, M.; Klocke, M.: Sample prefractionation with liquid isoelectric focusing enables in depth microbial metaproteome analysis of mesophilic and thermophilic biogas plants. Anaerobe 29, pp. 59 - 67 (2014)
  17. Lohr, V.; Hädicke, O.; Genzel, Y.; Jordan, I.; Buentemeyer, H.; Klamt, S.; Reichl, U.: The avian cell line AGE1.CR.pIX characterized by metabolic flux analysis. BMC Biotechnology 14, p. 72 (2014)
  18. Muth, T.; Weilnböck, L.; Rapp, E.; Huber, C. G.; Martens, L.; Vaudel, M.; Barnsnes, H.: DeNovoGUI: An Open Source Graphical User Interface for de Novo Sequencing of Tandem Mass Spectra. Journal of Proteome Research 13 (2), pp. 1143 - 1146 (2014)
  19. Rath, A.; Rehberg, M.; Janke, R.; Genzel, Y.; Scholz, S.; Noll, T.; Rose, T.; Sandig, V.; Reichl, U.: The influence of cell growth and enzyme activity changes on intracellular metabolite dynamics in AGE1.HN.AAT cells. Journal of Biotechnology 178, pp. 43 - 53 (2014)
  20. Rehberg, M.; Rath, A.; Ritter, J.; Genzel, Y.; Reichl, U.: Changes in intracellular metabolite pools during growth of adherent MDCK cells in two different media. Applied Microbiology and Biotechnology 98 (1), pp. 385 - 397 (2014)
  21. Rehberg, M.; Ritter, J.; Reichl, U.: Glycolysis Is Governed by Growth Regime and Simple Enzyme Regulation in Adherent MDCK Cells. PLoS Computational Biology 10 (10), p. e1003885 (2014)
  22. Rüger, M.; Ackermann, M.; Reichl, U.: Species-specific viability analysis of Pseudomonas aeruginosa, Burkholderia cepacia and Staphylococcus aureus in mixed culture by flow cytometry. BMC Microbiology 14, p. 56 - 56 (2014)
  23. Tapia, F.; Vogel, T.; Genzel, Y.; Behrendt, I.; Hirschel, M.; Gangemi, J. D.; Reichl, U.: Production of high-titer human influenza A virus with adherent and suspension MDCK cells cultured in a single-use hollow fiber bioreactor. Vaccine 32 (8), pp. 1003 - 1011 (2014)
  24. Wang, W.; Wolff, M. W.; Reichl, U.; Sundmacher, K.: Avidity of influenza virus: Model-based identification of adsorption kinetics from surface plasmon resonance experiments. Journal of Chromatography A 1326, pp. 125 - 129 (2014)
  25. Weigel, T.; Solomaier, T.; Peuker, A.; Pathapati, T.; Wolff, M. W.; Reichl, U.: A flow-through chromatography process for influenza A and B virus purification. Journal of Virological Methods 207, pp. 45 - 53 (2014)
  26. York, W.S.; Agravat, S.; Aoki-Kinoshita, K.F.; Mcbride, R.; Campell, F.; Castello, C.E.; Dell, A.; Feizi, T.; Haslam, S.M.; Karlsson, N. et al.; Khoo, K.-H.; Kolarich, D.; Liu, Y.; Novotny, M.; Packer, N.H.; Paulson, J.C.; Rapp, E.; Ranzinger, R.; Rudd, P.M.; Smith, D.F.; Struwe, W.B.; Tiemeyer, M.; Wells, L.; Zaia, J.; Kettner, C.: MIRAGE: The minimum information required for a glycomics experiment. Glycobiology 24 (5), pp. 402 - 406 (2014)
  27. 2013
    Bakovic, M.P.; Selman, M.H.J.; Hoffmann, M.; Rudan, I.; Campbell, H.; Deelder, A.M.; Lauc, G.; Wuhrer, M.: High-Throughput IgG Fc N-Glycosylation Profiling by Mass Spectrometry of Glycopeptides. Journal of Proteome Research 12 (2), pp. 821 - 831 (2013)
  28. Behne, A.; Muth, T.; Borowiak, M.; Reichl, U.; Rapp, E.: glyXalign: High-throughput migration time alignment preprocessing of electrophoretic data retrieved via multiplexed capillary gel electrophoresis with laser-induced fluorescence detection-based glycoprofiling. Electrophoresis 34 (16), pp. 2311 - 2315 (2013)
  29. Borchers, S.; Freund, S.; Rath, A.; Streif, S.; Reichl, U.; Findeisen, R.: Identification of Growth Phases and Influencing Factors in Cultivations with AGE1.HN Cells Using Set-Based Methods. PLoS One 8 (8), p. e68124 (2013)
  30. Bunz, S.-C.; Rapp, E.; Neusüss, C.: Capillary Electrophoresis/Mass Spectrometry of APTS-Labeled Glycans for the Identification of Unknown Glycan Species in Capillary Electrophoresis/Laser-Induced Fluorescence Systems. Analytical Chemistry 85 (21), pp. 10218 - 10224 (2013)
  31. Frensing, T.; Heldt, S.; Pflugmacher, A.; Behrendt, I.; Jordan, I.; Flockerzi, D.; Genzel, Y.; Reichl, U.: Continuous Influenza Virus Production in Cell Culture Shows a Periodic Accumulation of Defective Interfering Particles. PLoS One 8 (9), p. e72288 (2013)
  32. Freund, S.; Rath, A.; Barradas, O. P.; Skerhutt, S.; Scholz, S.; Niklas, J.; Sandig, V.; Rose, T.; Heinzle, E.; Noll, T. et al.; Pörtner, R.; Zeng, A. P.; Reichl, U.: Batch-to-batch variability of two human designer cell lines - AGE1.HN and AGE1.HN.AAT - carried out by different laboratories under defined culture conditions using a mathematical model. Engineering in Life Sciences 13 (6), pp. 580 - 592 (2013)
  33. Genzel, Y.; Behrendt, I.; Rödig, J.; Rapp, E.; Kueppers, C.; Kochanek, S.; Schiedner, G.; Reichl, U.: CAP, a new human suspension cell line for influenza virus production. Applied Microbiology and Biotechnology 97 (1), pp. 111 - 122 (2013)
  34. Genzel, Y.; Frensing, T.; Reichl, U.: Herstellung moderner Grippeimpfstoffe: Zellkultur statt Hühnerei. Chemie in unserer Zeit 47 (1), pp. 12 - 22 (2013)
  35. Hanreich, A.; Schimpf, U.; Zakrzewski, M.; Schlüter, A.; Benndorf, D.; Heyer, R.; Rapp, E.; Puhler, A.; Reichl, U.; Klocke, M.: Metagenome and metaproteome analyses of microbial communities in mesophilic biogas-producing anaerobic batch fermentations indicate concerted plant carbohydrate degradation. Systematic and Applied Microbiology 36 (5), pp. 330 - 338 (2013)
  36. Heldt, S.; Frensing, T.; Pflugmacher, A.; Gröpler, R.; Peschel, B.; Reichl, U.: Multiscale Modeling of Influenza A Virus Infection Supports the Development of Direct-Acting Antivirals. PLoS Computational Biology 9 (11), p. e1003372 (2013)
  37. Heyer, R.; Kohrs, F.; Benndorf, D.; Rapp, E.; Kausmann, R.; Heiermann, M.; Klocke, M.; Reichl, U.: Metaproteome analysis of the microbial communities in agricultural biogas plants. New biotechnology 30 (6), pp. 614 - 622 (2013)
  38. Hädicke, O.; Lohr, V.; Genzel, Y.; Reichl, U.; Klamt, S.: Evaluating differences of metabolic performances: Statistical methods and their application to animal cell cultivations. Biotechnology and Bioengineering 110 (10), pp. 2633 - 2642 (2013)
  39. Hütter, J.; Rödig, J. V.; Höper, D.; Seeberger, P. H.; Reichl, U.; Rapp, E.; Lepenies, B.: Toward Animal Cell Culture-based Influenza Vaccine Design: Viral Hemagglutinin N-Glycosylation Markedly Impacts Immunogenicity. The Journal of Immunology 190 (1), pp. 220 - 230 (2013)
  40. Jordan, I.; Lohr, V.; Genzel, Y.; Reichl, U.; Sandig, V.: Elements in the Development of a Production Process for Modified Vaccinia Virus Ankara. Microorganisms 1 (1), pp. 100 - 121 (2013)
  41. Kluge, S.; Rourou, S.; Vester, D.; Majoul, S.; Benndorf, D.; Genzel, Y.; Rapp, E.; Kallel, H.; Reichl, U.: Proteome analysis of virus-host cell interaction: rabies virus replication in Vero cells in two different media. Applied Microbiology and Biotechnology 97 (12), pp. 5493 - 5506 (2013)
  42. Kolarich, D.; Rapp, E.; Struwe, W. B.; Haslam, S. M.; Zaia, J.; McBride, R.; Agravat, S.; Campell, M. P.; Kato, M.; Ranzinger, R. et al.; Kettner, C.; York, W. S.: The Minimum Information Required for a Glycomics Experiment (MIRAGE) Project: Improving the Standards for Reporting Mass-spectrometry-based Glycoanalytic Data. Molecular and Cellular Proteomics 12 (4), pp. 991 - 995 (2013)
  43. Kottler, R.; Mank, M.; Hennig, R.; Müller-Werner, B.; Stahl, B.; Reichl, U.; Rapp, E.: Development of a high-throughput glycoanalysis method for the characterization of oligosaccharides in human milk utilizing multiplexed capillary gel electrophoresis with laser-induced fluorescence detection. Electrophoresis 34 (16), pp. 2323 - 2336 (2013)
  44. Kröber, T.; Wolff, M. W.; Hundt, B.; Seidel-Morgenstern, A.; Reichl, U.: Continuous purification of influenza virus using simulated moving bed chromatography. Journal of Chromatography A 1307, pp. 99 - 110 (2013)
  45. Muth, T.; Benndorf, D.; Reichl, U.; Rapp, E.; Martens, L.: Searching for a needle in a stack of needles: challenges in metaproteomics data analysis. Molecular BioSystems 9 (4), pp. 578 - 585 (2013)
  46. Muth, T.; Peters, J.; Blackburn, J.; Rapp, E.; Martens, L.: ProteoCloud: A full-featured open source proteomics cloud computing pipeline. Journal of Proteomics 88 (Special Issue: New Horizons and Applications for Proteomics [EuPA 2012]), pp. 104 - 108 (2013)
  47. Müller, T.; Dürr, R.; Isken, B.; Schulze-Horsel, J.; Reichl, U.; Kienle, A.: Distributed modeling of human influenza a virus-host cell interactions during vaccine production. Biotechnology and Bioengineering 110 (8), pp. 2252 - 2266 (2013)
  48. Neumann, A.; Hoyer, W.; Wolff, M. W.; Reichl, U.; Pfitzner, A.; Roth, B.: New method for density determination of nanoparticles using a CPS disc centrifuge (TM). Colloids and Surfaces B: Biointerfaces 104, pp. 27 - 31 (2013)
  49. Peschel, B.; Frentzel, S.; Laske, T.; Genzel, Y.; Reichl, U.: Comparison of influenza virus yields and apoptosis-induction in an adherent and a suspension MDCK cell line. Vaccine 31 (48), pp. 5693 - 5699 (2013)
  50. Rehberg, M.; Ritter, J. B.; Genzel, Y.; Flockerzi, D.; Reichl, U.: The relation between growth phases, cell volume changes and metabolism of adherent cells during cultivation. Journal of Biotechnology 164 (4), pp. 489 - 499 (2013)
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