Head of the Group

Dr.-Ing. Steffen Klamt
Dr.-Ing. Steffen Klamt
Phone: +49 391 6110 480
Fax: +49 391 6110 509
Room: S2.10


Susanne Hintsch
Phone:+49 391 6110-477Fax:+49 391 6110-452

News / Latest Publications

04.04.2018: New Publication
Klamt S, Müller S, Regensburger J, Zanghellini J (2018) A mathematical framework for yield (vs. rate) optimization in constraint-based modeling and applications in metabolic engineering. Metabolic Engineering 47: 153-169.

15.03.2018: de.NBI-Workshop April 24-26, 2018 at the MPI
We are co-organizing a workshop about modeling and data exchange in systems biology (presented software tools: COPASI, CellNetAnalyzer, SEEK, SABIO-RK). More information and registration via the following website.

23.02.2018: New Publication
Klamt S, Mahadevan R, Hädicke O (2018) When Do Two-Stage Processes Outperform One-Stage Processes? Biotechnology Journal 3: 1700539.   

07.12.2017: New Publication
Harder B-J, Bettenbrock K, Klamt S (2018) Temperature-dependent dynamic control of the TCA cycle increases volumetric productivity of itaconic acid production by Escherichia coli. Biotechnology and Bioengineering 115: 156-164.


Development of Software: CellNetAnalyzer and ProMoT

Many methods and algorithms developed and used by our group were implemented in our software package CellNetAnalyzer a comprehensive graphical user interface for MATLAB facilitating structural and functional analysis of metabolic and signaling networks [1]. Another software developed at the MPI is the modeling tool ProMoT, which provides a modular modeling concept for the systematic setup of dynamic and logical models [2]. ProMoT is tightly integrated with simulation and analyzing tools including Diana and CellNetAnalyzer. 

References cited above:

  1. Klamt S, Saez-Rodriguez J and Gilles ED (2007) Structural and functional analysis of cellular networks with CellNetAnalyzer. BMC Systems Biology 2:4.
  2. Mirschel, S, Steinmetz K, Rempel R, Ginkel M and Gilles ED (2009) PROMOT: modular modeling for systems biology. Bioinformatics 25:687-689.
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