Population balance modeling of virus replication during vaccine production

The subject of this project is population balance modeling of virus replication during vaccine production in mammalian cell cultures. The focus during this period of report has been on structured modeling based on detailed single cell kinetics and on corresponding efficient solution strategies for the resulting multidimensional population balance equations. Models and methods have been used to study the influence of host cell factors on virus yields.

Cooperation partners

  • Prof. Reichl, BPE group
  • partners of CellSys project

Publications

[1] S. Duvigneau, R. Dürr, T. Laske, M. Bachmann, M. Dostert, U. Reichl, and A. Kienle. Mathematical modeling as a tool to improve influenza vaccine production processes. In Proc. Foundations of Systems Biology in Engineering - FOSBE 2018 - Chicago, 5-8 August, 2018. IFAC-PapersOnLine, Volume 51, Issue 19, 2018, Pages 1-4.
[2] S. Duvigneau, R. Dürr, T. Laske, M. Bachmann, M. Dostert, and A. Kienle. Model-based approach for prediciting the impact of genetic modifications on product yield in biopharmaceutical manufacturing – Application to influenza vaccine production. PLOS Comput. Biol., 16(6):e1007810, 2020. DOI: 10.1371/journal.pcbi.1007810.

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