Control and regulation of balance of cell growth and degradation 

Deubiquitinases are enzymes that regulate important signal transduction processes and protein degradation in the human organism. Mutations and dysregulation lead to an uncontrolled cell growth. Pathogens from bacteria and viruses are able to circumvent the human innate immune response system by mimicking the host’s intrinsic deubiquitinases.  Computer simulations are able to reveal mechanistic details of these processes and provide insight into the structural dynamics of activation and function of deubiquitinase enzymes in pathogens and human.