Optimal Steady State and Transient Operation of SMB Chromatographic Processes

Simulated Moving Bed (SMB) chromatography integrating fractionation and feedback (FF-SMB) was proposed as a promising new concept by the PCF Group at MPI Magdeburg in 2007. Together with them, we have investigated model-based optimization of various FF-SMB configurations. In [1], it was demonstrated that optimal FF-SMB with fractionation of one outlet outperforms standard SMB both in terms of feed throughput and desorbent consumption. Fractionation of both outlets was investigated in [2], and it could be shown that achievable performance improves further. In [3], we successfully explored the possibility to enhance the potential of FF-SMB by additionally enriching the recycled fractions before feeding them back into the SMB unit.

Another part of this project is concerned with the optimisation of transient procedures for SMB processes. In particular, we have developed new multistage optimal startup and shutdown strategies [4][5]. For this, we suggest a specially tailored decomposition algorithm to guarantee computational tractability. By examining a separation example with Langmuir isotherm, the feasibility of the solution algorithm is demonstrated. The results illustrate that the proposed start-up and shut-down procedures not only significantly shorten transient duration, but also drastically reduce desorbent usage. Furthermore, it can be guaranteed that the required product quality is also achieved during the transient phase.


Publications

  1. ↑
    S. Li, Y. Kawajiri, J. Raisch, A. Seidel-Morgenstern. Optimization of simulated moving bed chromatography with fractionation and feedback: Part I. Fractionation of one outlet. Journal of Chromatography A, 1217 (33):5337-5348, 2010.
    Bibtex
    Author : S. Li, Y. Kawajiri, J. Raisch, A. Seidel-Morgenstern
    Title : Optimization of simulated moving bed chromatography with fractionation and feedback: Part I. Fractionation of one outlet
    In : Journal of Chromatography A,
          1217 (33):5337-5348, 2010.
    Date : 2010
     | PDF | DOI 
  2. ↑
    S. Li, Y. Kawajiri, J. Raisch, A. Seidel-Morgenstern. Optimization of simulated moving bed chromatography with fractionation and feedback: Part II. Fractionation of both outlets. Journal of Chromatography A, 1217 (33):5349-5357, 2010.
    Bibtex
    Author : S. Li, Y. Kawajiri, J. Raisch, A. Seidel-Morgenstern
    Title : Optimization of simulated moving bed chromatography with fractionation and feedback: Part II. Fractionation of both outlets
    In : Journal of Chromatography A,
          1217 (33):5349-5357, 2010.
    Date : 2010
     | PDF | DOI 
  3. ↑
    S. Li, Y. Kawajiri, J. Raisch, A. Seidel-Morgenstern. Optimization of simulated moving bed chromatography with fractionation and feedback incorporating an enrichment step. In Proc. of the 21st European Symposium on Computer Aided Process Engineering (ESCAPE 21), pages 818-822, Chalkidiki, Greece, 2011.
    Bibtex
    Author : S. Li, Y. Kawajiri, J. Raisch, A. Seidel-Morgenstern
    Title : Optimization of simulated moving bed chromatography with fractionation and feedback incorporating an enrichment step
    In : In Proc. of the 21st European Symposium on Computer Aided Process Engineering (ESCAPE 21),
          pages 818-822, Chalkidiki, Greece, 2011.
    Date : 2011
     | PDF | DOI 
  4. ↑
    S. Li, Y. Kawajiri, J. Raisch, A. Seidel-Morgenstern. Optimal startup operation of simulated moving bed chromatographic processes. In Proc. of the 9th IFAC Symposium on Dynamics and Control of Process Systems (DYCOPS 2010), pages 725-730, Leuven, Belgium, 2010.
    Bibtex
    Author : S. Li, Y. Kawajiri, J. Raisch, A. Seidel-Morgenstern
    Title : Optimal startup operation of simulated moving bed chromatographic processes
    In : In Proc. of the 9th IFAC Symposium on Dynamics and Control of Process Systems (DYCOPS 2010),
          pages 725-730, Leuven, Belgium, 2010.
    Date : 2010
     | PDF | DOI 
  5. ↑
    S. Li, Y. Kawajiri, J. Raisch, A. Seidel-Morgenstern. Optimization of startup and shutdown operation of simulated moving bed chromatographic processes. Journal of Chromatography A, 1218 (25):3876-3889, 2011.
    Bibtex
    Author : S. Li, Y. Kawajiri, J. Raisch, A. Seidel-Morgenstern
    Title : Optimization of startup and shutdown operation of simulated moving bed chromatographic processes
    In : Journal of Chromatography A,
          1218 (25):3876-3889, 2011.
    Date : 2011
     | PDF | DOI 
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