Head of the Group

Prof. Dr.-Ing. Udo Reichl
Prof. Dr.-Ing. Udo Reichl
Phone: +49 391 6110 201
Fax: +49 391 6110 203

Contact Person

Annegret Frauendienst
Phone: +49 391 6110 200
Fax: +49 391 6110 203

Group Page

Publications

Publications BPE group

Journal Article (18)

  1. 2010
    Benndorf, D.; Jach, M.; Klamt, S.; Reichl, U.: Systembiologie-Ausbildung von Anfang an. Systembiologie.de (2), pp. 82 - 84 (2010)
  2. Domann, P. J.; Akashi, S.; Barbas, C.; Huang, L.; Lau, W.; Legido-Quigley, C.; McClean, S.; Neusüß, C.; Perrett, D.; Quaglia, M. et al.; Rapp, E.; Smallshaw, L.; Smith, N. W.; Smyth, W. F.; Taylor, C. F.: Guidelines for reporting the use of capillary electrophoresis in proteomics. Nature biotechnology 28 (7), pp. 654 - 655 (2010)
  3. Genzel, Y.; Dietzsch, C.; Rapp, E.; Schwarzer, J.; Reichl, U.: MDCK and Vero cells for influenza virus vaccine production: a one-to-one comparison up to lab-scale bioreactor cultivation. Applied Microbiology and Biotechnology 88 (2), pp. 461 - 475 (2010)
  4. Heynisch, B.; Frensing, T.; Heinze, K.; Seitz, C.; Genzel, Y.; Reichl, U.: Differential activation of host cell signaling pathways through infection with two variants of influenza A /Puerto Rico /8/34 (H1N1) in MDCK cells. Vaccine 28 (51), pp. 8210 - 8218 (2010)
  5. Janke, R.; Genzel, Y.; Wahl, A.; Reichl, U.: Measurement of Key Metabolic Enzyme Activities in Mammalian Cells Using Rapid and Sensitive Microplate-Based Assays. Biotechnology and Bioengineering 107 (3), pp. 566 - 581 (2010)
  6. Janke, R.; Genzel, Y.; Freund, S.; Wolff, M. W.; Grammel, H.; Rühmkorf, C.; Seidemann, J.; Wahl, A.; Reichl, U.: Expression, purification, and characterization of a His6-tagged glycerokinase from Pichia farinosa for enzymatic cycling assays in mammalian cells. Journal of Biotechnology 150 (3), pp. 396 - 403 (2010)
  7. Kröber, T.; Knöchlein, A.; Eisold, K.; Kalbfuß-Zimmermann, B.; Reichl, U.: DNA Depletion by Precipitation in the Purification of Cell Culture-Derived Influenza Vaccines. Chemical Engineering and Technology 33 (6), pp. 941 - 959 (2010)
  8. Lohr, V.; Genzel, Y.; Behrendt, I.; Scharfenberg, K.; Reichl, U.: A new MDCK suspension line cultivated in a fully defined medium in stirred-tank and wave bioreactor. Vaccine 28 (38), pp. 6256 - 6264 (2010)
  9. Ritter, J.; Wahl, A.; Freund, S.; Genzel, Y.; Reichl, U.: Metabolic effects of influenza virus infection in cultured animal cells: Intra- and extracellular metabolite profiling. BMC Systems Biology 4, p. 61 (2010)
  10. Rollié, S.; Lendeckel, U.; Naumann, M.; Reichl, U.; Sundmacher, K.: Dynamics of bionanoparticle targeting in mixtures of human tumour cells by validated population balance modelling. Soft Matter 6 (6), pp. 1203 - 1216 (2010)
  11. Roma-Rodriguesa, C.; Santosa, P.; Benndorf, D.; Rapp, E.; Sá-Correiaa, I.: Response of Pseudomonas putida KT2440 to phenol at the level of membrane proteome. Proteomics 73 (8), pp. 1461 - 1478 (2010)
  12. Ruhaak, L.E.; Hennig, R.; Huhn, C.; Borowiak, M.; Dolhain, R.J.E.M.; Deelder, A.; Rapp, E.; Wuhrer, M.: Optimized Workflow for Preparation of APTS-Labeled N-Glycans Allowing High-Throughput Analysis of Human Plasma Glycomes using 48-Channel Multiplexed CGE-LIF. Journal of Proteome Research 9 (12), pp. 6655 - 6664 (2010)
  13. Seitz, C.; Frensing, T.; Höper, D.; Kochs, G.; Reichl, U.: High yields of Influenza A virus in MDCK cells are promoted by an insufficient IFN-induced antiviral state. Journal of General Virology 91 (7), pp. 1754 - 1763 (2010)
  14. Vester, D.; Rapp, E.; Kluge, S.; Genzel, Y.; Reichl, U.: Virus-host cell interactions in vaccine production cell lines infected with different human influenza A virus variants: A proteomic approach. Journal of Proteomics 73 (9), pp. 1656 - 1669 (2010)
  15. Vester, D.; Pflugmacher, A.; Hoffmann, D.; Seitz, C.; Heldt, S.; Bettenbrock, K.; Genzel, Y.; Reichl, U.: Real-time RT-qPCR assay for the analysis of human influenza A virus transcription and replication dynamics. Journal of Virological Methods 168 (1-2), pp. 63 - 71 (2010)
  16. Wolff, M.; Siewert, C.; Lehmann, S.; Hansen, S.P.; Djurup, R.; Faber, R.; Reichl, U.: Capturing of Cell Culture-Derived Modified Vaccinia Ankara Virus by Ion Exchange and Pseudo-Affinity Membrane Adsorbers. Biotechnology and Bioengineering 105 (4), pp. 761 - 769 (2010)
  17. Wolff, M.; Siewert, C.; Hansen, S. P.; Faber, R.; Reichl, U.: Purification of cell culture-derived modified Vaccinia Ankara virus by pseudo-affinity membrane adsorbers and hydrophobic interaction chromatography. Biotechnology and Bioengineering 107 (2), pp. 312 - 320 (2010)
  18. Öncül, A.; Kalmbach, A.; Genzel, Y.; Reichl, U.; Thevenin, D.: Characterization of flow conditions in 2 L and 20 L wave bioreactors using Computational Fluid Dynamics. Biotechnology Progress 26 (1), pp. 101 - 110 (2010)

Book Chapter (1)

  1. Mangold, M.; Schmidt, J. K.; Tobiska, L.; Tsotsas, E.: Modeling of Membrane Reactors. In: Membrane Reactors: Distributing Reactants to Improve Selectivity and Yield, pp. 29 - 62 (Ed. Seidel-Morgenstern, A.). Wiley-VCH, Weinheim (2010)

Conference Paper (8)

  1. Bock, A.; Genzel, Y.; Reichl, U.: Monitoring of Cell activity: online oxygen uptake rates in pulsed aerated cell culture. In: Cells and Culture: Proceedings of the 20th ESACT Meeting, pp. 391 - 396 (Ed. Noll, T.). 20th ESACT Meeting, Dresden, Germany, June 17, 2007 - June 20, 2007. (2010)
  2. Genzel, Y.; Dietzsch, C.; Reichl, U.: Comparing Vero and MDCK cells for influenza A virus production in microcarrier systems. In: Cells and Culture: Proceedings of the 20th ESACT Meeting, pp. 635 - 638 (Ed. Noll, T.). 20th ESACT Meeting, Dresden, Germany, June 17, 2007 - June 20, 2007. (2010)
  3. Ritter, J. B.; Genzel, Y.; Reichl, U.: Metabolite Analysis in Mammalian Cells: How to generate reliable data sets? In: Cells and Culture: Proceedings of the 20th ESACT Meeting, pp. 397 - 406 (Ed. Noll, T.). 20th ESACT Meeting, Dresden, Germany, June 17, 2007 - June 20, 2007. (2010)
  4. Schulze-Horsel, J.; Schulze, M.; Genzel, Y.; Reichl, U.: Single-cell approach in influenza vaccine production: apoptosis and virus protein production. In: Cells and Culture: Proceedings of the 20th ESACT Meeting, pp. 25 - 28 (Ed. Noll, T.). 20th ESACT Meeting, Dresden, Germany, June 17, 2007 - June 20, 2007. (2010)
  5. Schwarzer, J.; Rapp, E.; Reichl, U.: Glycosylation of Influenza A Virus Hemagglutinin. In: Cells and Culture: Proceedings of the 20th ESACT Meeting, pp. 621 - 624 (Ed. Noll, T.). 20th ESACT Meeting, Dresden, Germany, June 17, 2007 - June 20, 2007. (2010)
  6. Vester, D.; Rapp, E.; Genzel, Y.; Gade, D.; Reichl, U.: Proteomic analysis of influenza A virus infected mammalian cells by 2D-DIGE. In: Cells and Culture: Proceedings of the 20th ESACT Meeting, pp. 429 - 432 (Ed. Noll, T.). 20th ESACT Meeting, Dresden, Germany, June 17, 2007 - June 20, 2007. (2010)
  7. Wahl, A.; Sidorenko, Y.; Genzel, Y.; Reichl, U.: Metabolic flux distribution during growth of adherent growing MDCK cells in different media. In: Cells and Culture: Proceedings of the 20th ESACT Meeting, pp. 459 - 462 (Ed. Noll, T.). 20th ESACT Meeting, 2007-06-17, June 20, 2007. (2010)
  8. Öncül, A.A.; Janiga, G.; Genzel, Y.; Reichl, U.; Thévenin, D.: Two-population CFD simulation: microcarrier system for adherent cell growth in Wave Bioreactors. In: 4th International Conference on Population Balance Modelling: PBM 2010, pp. 667 - 681. 4th International Conference on Population Balance Modelling, Berlin, Germany, September 15, 2010 - September 17, 2010. (2010)

Meeting Abstract (2)

  1. Kuhn, R.; Benndorf, D.; Rapp, E.; Reichl, U.; Pollice, A.; Palese, L.: Metaproteomanalyse von Klärschlamm aus Membranbioreaktoren. In: Chemie Ingenieur Technik, Vol. 82, pp. 1539 - 1540 . Processet-Jahrestagung 2010 und 28. Jahrestagung der Biotechnologen, Aachen, Germany, September 21, 2010 - September 23, 2010. Verlag Chemie, GmbH, Weinheim, Germany (2010)
  2. Vester, D.; Rapp, E.; Kluge, S.; Genzel, Y.; Reichl, U.: Virus-Wirtszell-Interaktion bei der Produktion von Influenza A Impfstoff in tierischer Zellkultur: Änderungen des Proteoms von Produktionszelllinien. In: Chemie Ingenieur Technik, Vol. 82, p. 1496. ProcessNet-Jahrestagung 2010 und 28. Jahrestagung der Biotechnologen, Aachen, Germany, September 21, 2010 - September 23, 2010. (2010)

Talk (17)

  1. Frensing, T.; Seitz, C.; Heynisch, B.; Reichl, U.: Influence of Host Cell Defence during Influenza Vaccine Production in MDCK Cells. Vaccine Technology III, Puerto Vallarta, Mexiko (2010)
  2. Heynisch, B.; Frensing, T.; Seitz, C.; Reichl, U.: Induction of innate immunity signaling pathways in MDCK cells and their relevance in a bioprocess for influenza vaccine production. Molecular Interactions 2010, Berlin (2010)
  3. Kluge, S.; Vester, D.; Rapp, E.; Genzel, Y.; Reichl, U.: Virus-Wirtszell-Interaktion bei der Produktion von Influenza A Impfstoff in tierischer Zellkultur: Aenderungen des Proteoms von Produktionszelllinien. ProcessNet-Jahrestagung 2010 und 28. DECHEMA-Jahrestagung der Biotechnologen, Aachen (2010)
  4. Lagoda, A.; Genzel, Y.; Reichl, U.: Gene-specific transcription \& replication dynamics during human influenza A virus production. ESBES 2010, Bologna, Italy (2010)
  5. Lagoda, A.; Hoffmann, D.; Vester, D.; Seitz, C.; Genzel, Y.; Reichl, U.: Quantitative real time-PCR-assay for the analysis of gene-specific human influenza A virus transcription \& replication dynamics. qPCR 2010, Wien, Austria (2010)
  6. Rapp, E.: Towards High-Throughput Characterization of Carbohydrates Using a Capillary DNA-Sequencer. Meeting with Bayer-Schering, Berlin, Germany (2010)
  7. Rapp, E.; Hennig, R.; Roedig, J.; Schwarzer, J.; Reichl, U.: Glycosylation Pattern Analysis of Viral Antigens. 1st Workshop European Network on Viral Vaccine Processes (ENVVP), Dechema Haus, Frankfurt, Germany (2010)
  8. Rapp, E.; Hennig, R.; Roedig, J.; Reichl, U.: Towards High-Throughput Characterization of Carbohydrates Using a Capillary DNA-Sequencer. Colloqium at the MPI of Colloids and Interfaces, Dahlem/Berlin, Germany (2010)
  9. Reichl, U.: Metabolics and modeling to improve bioprocessing. ACTIP Meeting, Penzberg, Germany (2010)
  10. Reichl, U.: New Assay Platforms-a subjective selection. 1st Workshop on European Network on Viral Vaccine Processes: ENVVP, Franfurt am Main, Germany (2010)
  11. Riedele, C.; Reichl, U.: Growth Dynamics of a 3-Species Mixed Culture after an Antibiotic Pulse – Analyzed on the Single Species Level. 8th European Symposium on Biochemical Engineering Science (ESBES), Bologna, Italy (2010)
  12. Seitz, C.; Frensing, T.; Heynisch, B.; Reichl, U.: Einfluss der zelleigenen Pathogenabwehr auf die Influenza-Impfstoffproduktion in MDCK-Zellen. Dechema Jahrestagung, Aachen, Germany (2010)
  13. Wolff, M. W.; Reichl, U.: Downstream Processing of Cell Culture-Derived Influenza Virus. European network on Viral Vaccine Processes, Frankfurt, Germany (2010)
  14. Wolff, M. W.; Opitz, L.; Siewert, C.; Lehmann, S.; Hansen, S. P.; Faber, R.; Reichl, U.: Downstream Processing of Cell Culture-derived Virus Particles. Recovery of Biological Products XIV, Lake Tahoe, CA, USA (2010)
  15. Wolff, M.; Opitz, L.; Siewert, C.; Hansen, S. P.; Faber, R.; Reichl, U.: Downstream processing of cell culture derived Vaccinia and influenza virus particles. Vaccine Production & Manufacturing, Amsterdam, The Netherlands (2010)
  16. Wolff, M.; Opitz, L.; Siewert, C.; Lehmann, S.; Hansen, S. P.; Faber, R.; Reichl, U.: Membrane adsorbers to capture cell culture-derived virus particles. Vaccines R&D, Berlin, Germany (2010)
  17. Öncül, A.; Genzel, Y.; Reichl, U.; Thevenin, D.: Flow characterization and two-population simulation in wave bioreactors using Computational Fluid Dynamics. Bioprozessorientiertes Anlagendesign, Nürnberg, Germany (2010)

Poster (15)

  1. Frensing, T.; Seitz, C.; Heynisch, B.; Kochs, G.; Reichl, U.: Influence of Host Cell Defence during Influenza Vaccine Production in MDCK Cells. Cell Symposia: Influenza, Washington D.C., USA (2010)
  2. Frensing, T.; Seitz, C.; Heynisch, B.; Reichl, U.: Influence of host cell defence during influenza vaccine production in cell culture. 4th European Congress of Virology, Cernobbio, Como Lake, Italy (2010)
  3. Freund, S.; Sandig, V.; Rose, T.; Reichl, U.: Characterization of the metabolism of two new human cell lines in different cultivation systems. 8th European Symposium on Biochemical Engineering Science (ESBES), Bologna (2010)
  4. Heldt, F. S.; Reichl, U.: Modelling influenza virus infection dynamics in cell culture-based vaccine production. 11th International Conference on Systems Biology, Edinburgh, Scotland (2010)
 
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