M. Sc. Sebastián Espinel Ríos
Analysis and Redesign of Biological Networks
Max Planck Institute for Dynamics of Complex Technical Systems
Max Planck Institute for Dynamics of Complex Technical Systems
Main Focus
Modeling, estimation, optimization and control of bioprocesses with emphasis on metabolic cybergenetic systems. I seek to "communicate" with cells via external computer algorithms to optimize and control their metabolism online in a fully automated fashion.
Curriculum Vitae
Experience
- Doctoral Researcher. Max Planck Institute for Dynamics of Complex Technical Systems (Germany). 2019-present.
- Bioprocess Engineering Intern. The HEINEKEN Company (Netherlands). Feb-Jul 2019.
- Research Assistant. Cinvestav Irapuato (Mexico). Oct 2016-Apr 2017.
- Research Intern. University of Saskatchewan (Canada). May-Jul 2015.
- Research Intern. Cinvestav Irapuato (Mexico). Jun-Jul 2014.
Education
- Doctor of Engineering (Process Engineering). Otto von Guericke University Magdeburg (Germany). 2019-present.
- MSc Biotechnology (Process Technology). Wageningen University & Research (Netherlands). 2017-2019.
- BSc Biotechnology Engineering. Autonomous University of Yucatan (Mexico). 2011-2016.
Scientific productivity
In press, peer-reviewed
- Cell-free biosynthesis meets dynamic optimization and control: a fed-batch framework. IFAC-PapersOnLine.
- Soft sensor for monitoring dynamic changes in cell composition. IFAC-PapersOnLine.
- Efficient and simple gaussian process supported stochastic model predictive control for bioreactors using HILO-MPC. IFAC-PapersOnLine.
- Optimal control and dynamic modulation of the ATPase gene expression for enforced ATP wasting in batch fermentations. IFAC-PapersOnLine.
Published, peer-reviewed
- Enabling anaerobic growth of Escherichia coli on glycerol in defined minimal medium using acetate as redox sink. Metab Eng (2022).
- Maximizing batch fermentation efficiency by constrained model‐based optimization and predictive control of adenosine triphosphate turnover. AIChE J (2022).
- Production of 1,3-propanediol from crude glycerol: bioprocess design and profitability analysis. Rev Mex Ing Quim (2019).
- A Plackett-Burman design for substituting MRS medium components with avocado seed hydrolysate for growth and lactic acid production by Lactobacillus sp. Rev Mex Ing Quim (2018).
- Optimization of biological pretreatment to enhance the quality of wheat straw pellets. Biomass Bioenergy (2017).
Patents
- Culture medium derived from avocado seed material. PAT: WO/2016/079568.
Others
- Enhancing the physical quality of barley straw pellets by optimizing biological pretreatment. ASABE Annu Int Meet (2016).
Supervised theses
- Economic model predictive control and real time optimization for a two bioreactor-system using machine learning for price prediction (Siddharth Patel, OVGU, 2021).
Check here for a master's thesis opportunity in the field of physics-informed machine learning for bioreactor control.
- Doctoral Researcher. Max Planck Institute for Dynamics of Complex Technical Systems (Germany). 2019-present.
- Bioprocess Engineering Intern. The HEINEKEN Company (Netherlands). Feb-Jul 2019.
- Research Assistant. Cinvestav Irapuato (Mexico). Oct 2016-Apr 2017.
- Research Intern. University of Saskatchewan (Canada). May-Jul 2015.
- Research Intern. Cinvestav Irapuato (Mexico). Jun-Jul 2014.
Education
- Doctor of Engineering (Process Engineering). Otto von Guericke University Magdeburg (Germany). 2019-present.
- MSc Biotechnology (Process Technology). Wageningen University & Research (Netherlands). 2017-2019.
- BSc Biotechnology Engineering. Autonomous University of Yucatan (Mexico). 2011-2016.
Scientific productivity
In press, peer-reviewed
- Cell-free biosynthesis meets dynamic optimization and control: a fed-batch framework. IFAC-PapersOnLine.
- Soft sensor for monitoring dynamic changes in cell composition. IFAC-PapersOnLine.
- Efficient and simple gaussian process supported stochastic model predictive control for bioreactors using HILO-MPC. IFAC-PapersOnLine.
- Optimal control and dynamic modulation of the ATPase gene expression for enforced ATP wasting in batch fermentations. IFAC-PapersOnLine.
Published, peer-reviewed
- Enabling anaerobic growth of Escherichia coli on glycerol in defined minimal medium using acetate as redox sink. Metab Eng (2022).
- Maximizing batch fermentation efficiency by constrained model‐based optimization and predictive control of adenosine triphosphate turnover. AIChE J (2022).
- Production of 1,3-propanediol from crude glycerol: bioprocess design and profitability analysis. Rev Mex Ing Quim (2019).
- A Plackett-Burman design for substituting MRS medium components with avocado seed hydrolysate for growth and lactic acid production by Lactobacillus sp. Rev Mex Ing Quim (2018).
- Optimization of biological pretreatment to enhance the quality of wheat straw pellets. Biomass Bioenergy (2017).
Patents
- Culture medium derived from avocado seed material. PAT: WO/2016/079568.
Others
- Enhancing the physical quality of barley straw pellets by optimizing biological pretreatment. ASABE Annu Int Meet (2016).
Supervised theses
- Economic model predictive control and real time optimization for a two bioreactor-system using machine learning for price prediction (Siddharth Patel, OVGU, 2021).
Check here for a master's thesis opportunity in the field of physics-informed machine learning for bioreactor control.