M. Sc. Sebastián Espinel Ríos

Analysis and Redesign of Biological Networks
Max Planck Institute for Dynamics of Complex Technical Systems
+49 391 6110 380

Main Focus

Modeling, estimation, optimization and control of bioprocesses with emphasis on metabolic cybergenetic systems. I seek to "communicate" with cells via external computer algorithms to optimize and control their metabolism online in a fully automated fashion.

Curriculum Vitae

- Doctoral Researcher. Max Planck Institute for Dynamics of Complex Technical Systems (Germany). 2019-present.
- Bioprocess Engineering Intern. The HEINEKEN Company (Netherlands). Feb-Jul 2019.
- Research Assistant. Cinvestav Irapuato (Mexico). Oct 2016-Apr 2017.
- Research Intern. University of Saskatchewan (Canada). May-Jul 2015.
- Research Intern. Cinvestav Irapuato (Mexico). Jun-Jul 2014.
- Doctor of Engineering (Process Engineering). Otto von Guericke University Magdeburg (Germany). 2019-present.
- MSc Biotechnology (Process Technology). Wageningen University & Research (Netherlands). 2017-2019.
- BSc Biotechnology Engineering. Autonomous University of Yucatan (Mexico). 2011-2016.
Scientific productivity
In press, peer-reviewed
- Cell-free biosynthesis meets dynamic optimization and control: a fed-batch framework. IFAC-PapersOnLine.
- Soft sensor for monitoring dynamic changes in cell composition. IFAC-PapersOnLine.
- Efficient and simple gaussian process supported stochastic model predictive control for bioreactors using HILO-MPC. IFAC-PapersOnLine.
- Optimal control and dynamic modulation of the ATPase gene expression for enforced ATP wasting in batch fermentations. IFAC-PapersOnLine.
Published, peer-reviewed
- Enabling anaerobic growth of Escherichia coli on glycerol in defined minimal medium using acetate as redox sink. Metab Eng (2022).
- Maximizing batch fermentation efficiency by constrained model‐based optimization and predictive control of adenosine triphosphate turnover. AIChE J (2022).
- Production of 1,3-propanediol from crude glycerol: bioprocess design and profitability analysis. Rev Mex Ing Quim (2019).
- A Plackett-Burman design for substituting MRS medium components with avocado seed hydrolysate for growth and lactic acid production by Lactobacillus sp. Rev Mex Ing Quim (2018).
- Optimization of biological pretreatment to enhance the quality of wheat straw pellets. Biomass Bioenergy (2017).
- Culture medium derived from avocado seed material. PAT: WO/2016/079568.
- Enhancing the physical quality of barley straw pellets by optimizing biological pretreatment. ASABE Annu Int Meet (2016).
Supervised theses
- Economic model predictive control and real time optimization for a two bioreactor-system using machine learning for price prediction (Siddharth Patel, OVGU, 2021).
Check here for a master's thesis opportunity in the field of physics-informed machine learning for bioreactor control.
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