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Raum: Großer Seminarraum "Prigogine" Ort: Max-Planck-Institut Magdeburg
1948 1447321899

MPI Kolloquiumsreihe: Plant-Based Biopharmaceuticals: How to Move New Product Candidates Towards Translational Research and Market

Kolloquium
The development of recombinant antibodies and vaccines has allowed us to treat and prevent a large number of life-threatening diseases. However, as things stand in 2015, the speed, capacity and scalability of current production systems is beginning to place limitations on this crucial technology. The large-scale production of antibodies, vaccines and other pharmaceutical recombinant proteins is restricted by the industry’s current reliance on fermenter technology, particularly the culture of mammalian cells. This expensive and time-consuming production platform is preventing the distribution of recombinant protein drugs to those most in need. One way in which the above limitations can be addressed is through the use of plants and plant-based expression systems for rapid recombinant pharmaceutical protein production. The economic production of plant-based pharmaceuticals depends on satisfactory yields and product quality. This presentation will discuss the latest development in antibody and vaccine development and their production by molecular farming, focusing particularly on strategies to maximize protein yields during upstream production and optimize protein recovery in the downstream processing steps. Such strategies often involve careful consideration of how the protein is expressed and targeted within the plant cell, a factor which affects yield, stability, quality and ease of isolation. Our long-term objective is to ensure that next generation of plantbased production systems for recombinant proteins will create the opportunity to deliver antibodies, vaccines and other biopharmaceuticals beyond the industrialized nations and into the developing world. Several case studies will be presented: HIV antibodies were chosen to undergo fast-track development, including risk assessment, expression in tobacco, scale-up, downstream processing and regulatory development, with the aim of performing clinical trials. In addition use of engineered plant cells for human vaccine candidates will be discussed. Pharma-Planta is an EU Sixth Framework Integrated Project whose primary goal is to develop an approved production pipeline for plant-derived pharmaceutical proteins (PDPs). Although previous research has provided proof of the PDP concept, Pharma-Planta aims to develop an entire production chain by taking candidate pharmaceutical molecules from the expression platform through all stages of production and processing, ultimately to initiate phase I human trials in Europe. The Pharma-Planta Consortium comprised 40 interacting groups representing 33 public institutes and SMEs from 11 European Member States and South Africa. At the beginning of the project, eight target molecules were chosen representing four key indication areas including HIV. From these molecules, two HIV antibodies were chosen to undergo fast-track development, which would include risk assessment, cloning, expression and optimization of production in plants, scale-up, downstream processing and regulatory development, with the aim of submitting at least one of them for clinical trials within the five years of the program. Two HIV neutralizing antibodies have been expressed successfully in the two main production crops being developed within the consortium – maize and tobacco. One of these antibodies, 2G12, has been expressed at levels greater 100 mg per kg of plant material. The plant-derived antibodies remain stable and functional and retain their neutralizing activity. The consortium has investigated novel upscaling and downstream processing strategies to provide multiple grams clinical grade antibody material for human clinical trials. Preclinical trials in rabbits have been completed successfully and we also conducted successfully a phase I clinical trial in the UK. This work will now be moved forward for a phase IIa clinical trial which is funded by an Advanced ERC grant from the European Commission. We have also developed an interesting multi-stage malaria vaccine and neutralizing rabies antibody candidates and will discuss how both products have matured over the years both in performance and in manufacturing with the aim in mind to bring these two products into translational research within the next months. Finally state of the art technology developments to accelerate the development and production of PMPs as well as regulatory issues will be discussed. Along this line an innovative new manufacturing concept using LED lighting in a vertical farm concept have been developed. [mehr]

Synthetic Biology and delivering on, From Gene to Product

Vortrag im Rahmen der Hybrid Modeling Summer School
Abstract: To some people we may be entering the period of the ‘Fourth Industrial Revolution’ - the Biological Industrial Revolution. Just as in previous industrial revolutions the potential previously promised by coal, mechanisation and electronics has now to be realised by the exploitation of biological potential. This new potential is made available by large scale gene synthesis and expression and understanding the options available for the scale-up and control of novel genetic entities. It seems that in order to start to understand fully how the exploitation of novel biological potential may be realised there needs to be a recognition of the scale and complexity of the task. Novel methodologies in numerical analysis and experimental design as well as in automation and bioprocess engineering need to be employed and coordinated in order to gain commercial traction on synthetic biology. This short talk will seek to identify how techniques of large scale experimental design, scale up and analyses, as well as a novel approach to biological automation are seeking to address just some of the issues surrounding Synthetic Biology and delivering on ‘From Gene to Product’. Short biography of Mr. Craig JL Gershater: Craig is a senior scientist and manager with over 40 years’ industrial bioprocess optimisation and biotechnology experience. He has held a variety of senior positions in the pharmaceutical industry, lastly as Head of Fermentation Sciences R&D at SmithKline Beecham prior to becoming the CEO and Principal Consultant with Cambridge Bioprocess Management Ltd in 2000. Among his many transnational clients in recent years he has worked with GSK, as well as a number of SMEs and in academia. He is an expert in the application of statistical methods to experimental design and rapid bioprocess optimisation. He has used these techniques in a wide variety of industrial research and development projects including full scale development of biotechnology projects to GMP/GLP requirements. [mehr]

Homogeneous Catalytic In-Situ Spectroscopic Measurements and Chemometrics - An Overview of Activities at the National Laboratories in Singapore (A*STAR)

Homogeneous Catalytic In-Situ Spectroscopic Measurements and Chemometrics - An Overview of Activities at the National Laboratories in Singapore (A*STAR)
2597 1443105110

Symposium on Advances and Applications in Metaproteomics

Symposium on Advances and Applications in Metaproteomics
3552 1447323304

DECHEMA Kolloquium: Continuous Manufacturing: Old Concept - New Applications

DECHEMA Kolloquium: Continuous Synthesis: Old Concept - New Applications
The large scale production of bulk chemicals is performed in the chemical process industry frequently applying continuously operated reaction and separation processes. In the fields of “Flow chemistry” and “Continuous Manufacturing” there are currently significant efforts to apply similar principles for the production of fine chemicals and pharmaceuticals, which is traditionally based on batch processes. The current status will be discussed and similarities and differences between the two fields will be highlighted. [mehr]
5093 1458287812

Vortrag: Processing of functional nanoparticles: From automated synthesis to tailored surface properties and applications

Vortrag: Processing of functional nanoparticles: From automated synthesis to tailored surface properties and applications
4464 1455806910
Dieser Vortrag ist Teil der Kolloquiumsreihe am Max-Planck-Institut Magdeburg. Alle Interessierten sind herzlich eingeladen. [mehr]

A Fast Solver for a Nonsmooth Optimization problem in a phase separation model

A Fast Solver for a Nonsmooth Optimization problem in a phase separation model

Promotionskolloquium: Model Order Reduction for Parameterized Nonlinear Evolution Equations

Promotionskolloquium: Model Order Reduction for Parameterized Nonlinear Evolution Equations

Promotionskolloquium: Low-Rank Iterative Solvers for Large-Scale Stochastic Galerkin Linear Systems

Promotionskolloquium: Low-Rank Iterative Solvers for Large-Scale Stochastic Galerkin Linear Systems

Promotionskolloquium: Numerical Aspects of Flow Stabilization by Riccati Feedback

Promotionskolloquium: Numerical Aspects of Flow Stabilization by Riccati Feedback

Promotionskolloquium: Balancing Related Model Order Reduction Applied to Linear Controlled Evolution Equations with Lévy Noise

Promotionskolloquium: Balancing Related Model Order Reduction Applied to Linear Controlled Evolution Equations with Lévy Noise

Promotionskolloquium: Reduced Basis Approximations for Electromagnetic Applications

Promotionskolloquium: Reduced Basis Approximations for Electromagnetic Applications

Promotionskolloquium: Continuous Preferential Crystallization of Enantiomers: Simulation, Analysis, Process Design and Experimental Validation

Promotionskolloquium: Continuous Preferential Crystallization of Enantiomers: Simulation, Analysis, Process Design and Experimental Validation

Promotionskolloquium: The Structural Dynamics of Soluble and Membrane Proteins Explored through Molecular Simulations

Promotionskolloquium: The Structural Dynamics of Soluble and Membrane Proteins Explored through Molecular Simulations

Promotionskolloquium: Etablierung und Anwendung einer durchflusszytometrischen Methode für die Vitalitätsbestimmung von P. aeruginosa, B. cepacia und S. aureus in Mischkulturen

Promotionskolloquium: Etablierung und Anwendung einer durchflusszytometrischen Methode für die Vitalitätsbestimmung von P. aeruginosa, B. cepacia und S. aureus in Mischkulturen

Toward a more sustainable chemical industry: terpenes and arylpropenoids as feedstock in transition metal complex catalyzed reactions

Toward a more sustainable chemical industry: terpenes and arylpropenoids as feedstock in transition metal complex catalyzed reactions

Promotionskolloquium: Modellbasierte Bestimmung von Interventionsstrategien zur Optimierung der Produktion von Biokraftstoffen in Cyanobakterien

Promotionskolloquium: Modellbasierte Bestimmung von Interventionsstrategien zur Optimierung der Produktion von Biokraftstoffen in Cyanobakterien
5940 1478793030

MPI Kolloquiumsreihe: Prof. Dr. Walter Stahel: Opportunity and Risk - Two Sides of Systems' Solutions

MPI Kolloquiumsreihe: Prof. Dr. Walter Stahel: Opportunity and Risk - Two Sides of Systems' Solutions

Ehrenkolloquium für Prof. Dietrich Flockerzi

Ehrenkolloquium für Prof. Dietrich Flockerzi

Prof. Dr. Herbert Sixta: Fractionation and Valorization of Biomass

Prof. Dr. Herbert Sixta: Fractionation and Valorization of Biomass
5942 1484821719

MPI Kolloquiumsreihe: Prof. Jean-Michel Coron, Stabilization of control systems: From the clepsydras to the regulation of the rivers La Sambre and La Meuse

MPI Kolloquiumsreihe: Prof. Jean-Michel Coron, Stabilization of control systems: From the clepsydras to the regulation of the rivers La Sambre and La Meuse
6690 1485518233

ENTFÄLLT: MPI Kolloquiumsreihe: Prof. Dr. Rainer Fischer

ENTFÄLLT: MPI Kolloquiumsreihe: Prof. Dr. Rainer Fischer
8340 1488285320

MPI Kolloquiumsreihe: Prof. Dr. Jan-Dierk Grunwaldt, Challenges in Environmental and Energy-related Catalysis: Understanding Catalysts under Dynamic Reaction Conditions

MPI Kolloquiumsreihe: Prof. Dr. Jan-Dierk Grunwaldt, Challenges in Environmental and Energy-related Catalysis: Understanding Catalysts under Dynamic Reaction Conditions
9158 1489061273

Industry Career Workshop “From academia to industry: applied research and career challenges”

Industry Career Workshop “From academia to industry: applied research and career challenges”
5944 1488468414

MPI Kolloquiumsreihe: Prof. Martha Grover, Crystallization Control using Dynamic Programming

MPI Kolloquiumsreihe: Prof. Martha Grover, Crystallization Control using Dynamic Programming
8345 1491492267

MPI Kolloquiumsreihe: Prof. Dr. Philip Tinnefeld, DNA in new roles: Tools for Superresolution and Nanobiotechnology

MPI Kolloquiumsreihe: Prof. Dr. Philip Tinnefeld, DNA in new roles: Tools for Superresolution and Nanobiotechnology

Prof. Dr. Joris Thybaut, Microkinetic modeling: a strategy to govern the phenomena from the active site to the chemical reactor

Prof. Dr. Joris Thybaut, Microkinetic modeling: a strategy to govern the phenomena from the active site to the chemical reactor

Dr. Matthias Thommes: Recent Advances in the Textural Characterization of Hierarchically Structured Nanoporous Materials

Dr. Matthias Thommes: Recent Advances in the Textural Characterization of Hierarchically Structured Nanoporous Materials
8348 1494322862

ENTFÄLLT MPI Kolloquiumsreihe: Prof. Dr. Wolfgang Wiechert, From wild type microbes to industrial chassis organisms

ENTFÄLLT MPI Kolloquiumsreihe: Prof. Dr. Wolfgang Wiechert, From wild type microbes to industrial chassis organisms

Promotionskolloquium: Investigation of influenza virus particle aggregation and purification with magnetic sulfated cellulose particles

Promotionskolloquium: Investigation of influenza virus particle aggregation and purification with magnetic sulfated cellulose particles
6688 1494856629

MPI Kolloquiumsreihe: Prof. Dr. Athanasios C. Antoulas, Data-driven model reduction of large-scale systems

MPI Kolloquiumsreihe: Prof. Dr. Athanasios C. Antoulas, Data-driven model reduction of large-scale systems
9998 1496755567

MPI Kolloquiumsreihe: Prof. Dr. Katalin M. Hangos, Dynamics and stabilizing control of nonlinear process networks

MPI Kolloquiumsreihe: Prof. Dr. Katalin M. Hangos, Dynamics and stabilizing control of nonlinear process networks
8883 1502463717

MPI Kolloquiumsreihe: Prof. Dr. Ulrich Pöschl, Multiphase Chemical Kinetics at the Interface of Earth and Life Sciences

MPI Kolloquiumsreihe: Prof. Dr. Ulrich Pöschl, Multiphase Chemical Kinetics at the Interface of Earth and Life Sciences
9823 1506412720

MPI Kolloquiumsreihe: Prof. Dr. Peter H. Seeberger, Preventing and Fighting Infectious Diseases: Carbohydrate Vaccines and Flow Chemistry

MPI Colloquia Series: Prof. Dr. Peter H. Seeberger, Preventing and Fighting Infectious Diseases: Carbohydrate Vaccines and Flow Chemistry
11184 1507127539

3. MAXNET Energy Workshop

3. MAXNET Energy Workshop

Industrial scale preparation of enantiopure compounds by melt crystallization – Applications, Process and Equipment

Industrial scale preparation of enantiopure compounds by melt crystallization – Applications, Process and Equipment
11613 1511174361

MPI Kolloquiumsreihe: Dr. JP Huang, Macroscopic Collapse: Energy of Ownership

MPI Kolloquiumsreihe: Dr. JP Huang, Macroscopic Collapse: Energy of Ownership
9642 1510561253

MPI Kolloquiumsreihe: Prof. Dr. Gene Myers, Computer Vision and Computational Optics for Bioimage Informatics

MPI Kolloquiumsreihe: Prof. Dr. Gene Myers, Computer Vision and Computational Optics for Bioimage Informatics

OPOSPM: A Reduced Population Balance Model that Works

OPOSPM: A Reduced Population Balance Model that Works
12451 1515683152

Magdeburg Lectures on Optimization and Control: Optimal control, optimization, market mechanisms and physics of smart energy systems

Magdeburg Lectures on Optimization and Control: Optimal control, optimization, market mechanisms and physics of smart energy systems
11561 1516629118

MPI Kolloquiumsreihe: Prof. Dr. Berend van Wachem, On the behaviour of particles, droplets and interfaces - Studying the Small Scale Physics to Improve the Understanding of Large-Scale Processes

MPI Kolloquiumsreihe: Prof. Dr. Berend van Wachem

Prof. Florian M. Wurm: The Billion Dollar CHO: Cells with mysteries for ton-quantity production of biopharmaceuticals

The Billion Dollar CHO: Cells with mysteries for ton-quantity production of biopharmaceuticals

Promotionskolloquium: System-Theoretic Model Order Reduction for Bilinear and Quadratic-Bilinear Control Systems

Promotionskolloquium: System-Theoretic Model Order Reduction for Bilinear and Quadratic-Bilinear Control Systems
13035 1519912716

MPI Kolloquiumsreihe: Prof. Marc Timme, Braess' Paradox, Anomalous Fluctuations and Nonlocal Rerouting in Power Grids - Collective Nonlinear Dynamics of Networks

MPI Kolloquiumsreihe: Prof. Marc Timme, Braess' Paradox, Anomalous Fluctuations and Nonlocal Rerouting in Power Grids - Collective Nonlinear Dynamics of Networks
12997 1519315064

Tools for Systems Biology Modeling and Data Exchange: COPASI, CellNetAnalyzer, SABIO-RK, SEEK

Tools for Systems Biology Modeling and Data Exchange: COPASI, CellNetAnalyzer, SABIO-RK, SEEK
12600 1516808422

MPI Kolloquiumsreihe: Prof. Dr. Walter Leitner, Direktor am Max-Planck-Institut für Chemische Energiekonversion, Mühlheim a.d. Ruhr

MPI Kolloquiumsreihe: Prof. Dr. Walter Leitner

Prof. Feng Qian: Smart Manufacturing for Process Industry

Prof. Feng Qian: Smart Manufacturing for Process Industry

Dr. Jonathan Bloh: Optimierung und effiziente Skalierung von photokatalytischen Prozessen - Kinetik, Quantenausbeute und Reaktoren

Dr. Jonathan Bloh: Optimierung und effiziente Skalierung von photokatalytischen Prozessen - Kinetik, Quantenausbeute und Reaktoren
13374 1534494560

MPI Kolloquiumsreihe: Prof. Dr. Regina Palkovits, Heterogeneous Catalysis and electro-catalysis as elements of an efficient and flexible use of renewable carbon resources

MPI Kolloquiumsreihe: Prof. Dr. Regina Palkovits, RWTH Aachen
15071 1537787838

MPI Kolloquiumsreihe: Prof. Dr. Nicole Borth, Next Generation CHO and how we might eventually get there

MPI Kolloquiumsreihe: Prof. Dr. Nicole Borth, Next Generation CHO and how we might eventually get there
15780 1539785526

MPI Kolloquiumsreihe: Dr. Julia E. Rice, The Diversity of Scientific Projects at IBM Research

MPI Kolloquiumsreihe: Dr. Julia E. Rice, The Diversity of Scientific Projects at IBM Research
15962 1540819233

MPI Kolloquiumsreihe: Prof. Giorgio Carta, Advances in Mechanistic Understanding and Modeling of Protein Process Chromatography

MPI Kolloquiumsreihe: Prof. Giorgio Carta, Advances in Mechanistic Understanding and Modeling of Protein Process Chromatography
15078 1534509738

MPI Kolloquiumsreihe: Dr. Adam Weber, Exploring Polymer-Electrolyte Fuel Cells using Physics-Based Modeling

MPI Kolloquiumsreihe: Dr. Adam Weber, Exploring Polymer-Electrolyte Fuel Cells using Physics-Based Modeling
16495 1545043872

MPI Kolloquiumsreihe: Univ.-Prof. Dipl.-Ing. Dr. Barbara Kaltenbacher: Iterative regularization of time-dependent inverse problems

MPI Kolloquiumsreihe: Univ.-Prof. Dipl.-Ing. Dr. Barbara Kaltenbacher: Iterative regularization of time-dependent inverse problems
16494 1547565768

MPI Kolloquiumsreihe: Prof. Dr. Dörte Rother, Synthetic enzyme cascades – from set-up to economic and ecologic efficiency studies

MPI Kolloquiumsreihe: Prof. Dr. Dörte Rother
16491 1547642125

MPI Kolloquiumsreihe: Prof. Dr. Wolfgang Wiechert, Simulating huge Bioreactors in tiny Chips: Technologies for Microbial Single Cell Analysis

MPI Kolloquiumsreihe: Prof. Dr. Wolfgang Wiechert, Systems Biotechnology, Forschungszentrum Jülich
11773 1552465675

MPI Kolloquiumsreihe: Prof. Dr. Paul Wilmes, Systems Ecology of Microbiomes: Identifying Key Functions

MPI Kolloquiumsreihe: Prof. Dr. Paul Wilmes, Systems Ecology of Microbiomes: Identifying Key Functions
17348 1554730030

MPI Kolloquiumsreihe: Prof. Dr. Helmut Cölfen, Non-classical crystallization of organic molecules

MPI Kolloquiumsreihe: Prof. Dr. Helmut Cölfen, Non-classical crystallization of organic molecules
17967 1552301680

1.Workshop zu Nachhaltigkeit in der Max-Planck-Gesellschaft

1.Workshop Nachhaltigkeit in der Max-Planck-Gesellschaft
17739 1557315634

ENTFÄLLT: MPI Kolloquiumsreihe: Prof. John Yin, Paths to biological polymers: an insight from virus infections and the chemical origins of life

MPI Kolloquiumsreihe: Prof. John Yin, Paths to biological polymers: an insight from virus infections and the chemical origins of life
17568 1552466859

MPI Kolloquiumsreihe: Prof. Gregory S. Yablonsky, Chemical Calculus: A New Paradigm of Chemical Kinetics

MPI Kolloquiumsreihe: Prof. Gregory S. Yablonsky, Chemical Calculus: A New Paradigm of Chemical Kinetics
17571 1560860876

MPI Kolloquiumsreihe: Prof. Oliver Trapp, Early Pathways to Life: Mechanisms to DNA, Molecular Evolution and Homochirality

MPI Kolloquiumsreihe: Prof. Oliver Trapp, Early Pathways to Life: Mechanisms to DNA, Molecular Evolution and Homochirality
19470 1563779652

MPI Kolloquiumsreihe: PD Dr. Michael Bortz, Adaptive strategies to explore Pareto frontiers in chemical process design

MPI Kolloquiumsreihe: PD Dr. Michael Bortz, Adaptive strategies to explore Pareto frontiers in chemical process design
19987 1567504753

MPI Kolloquiumsreihe: Prof. Jennifer Wilcox, Comparison of CO2 Capture from Point Sources vs the Atmosphere and Scales of Utilization

MPI Kolloquiumsreihe: Prof. Jennifer Wilcox, Comparison of CO2 Capture from Point Sources vs the Atmosphere and Scales of Utilization
22430 1572948166

MPI Kolloquiumsreihe: Prof. James M. Piret, Technologies Tailored for Cell Therapy Manufacturing

MPI Kolloquiumsreihe: Prof. James M. Piret, Technologies Tailored for Cell Therapy Manufacturing
20890 1573047602

DECHEMA-Kolloquium "Rohstoffe aus Abfällen: Neue Konzepte für die zukünftige Kreislaufwirtschaft"

DECHEMA-Kolloquium "Rohstoffe aus Abfällen: Neue Konzepte für die zukünftige Kreislaufwirtschaft"
20109 1572256939

ENTFÄLLT: MPI Kolloquiumsreihe: Prof. Dr. Christoph Wittmann, Systems metabolic engineering of industrial microorganisms

MPI Kolloquiumsreihe: Prof. Dr. Christoph Wittmann, Systems metabolic engineering of industrial microorganisms
20041 1574262604

MPI Kolloquiumsreihe / FMA Kolloquium: Prof. Dr. Axel Klawonn, Robust and parallel scalable domain decomposition methods forproblems in solid mechanics

MPI Kolloquiumsreihe: Prof. Dr. Axel Klawonn, Robust and parallel scalable domain decomposition methods
22047 1573563537

MPI Kolloquiumsreihe: Dr. Janina Bahnemann, 3D-printed Microfluidic Systems for Cell Culture and Biological Applications

MPI Kolloquiumsreihe: Dr. Janina Bahnemann, 3D-printed Microfluidic Systems for Cell Culture and Biological Applications
23854 1583911409

VERSCHOBEN: MPI Kolloquiumsreihe: Prof. Dr. rer. nat. Michael H. Eikerling, Institut für Energie und Klimaforschung, Forschungszentrum Jülich

MPI Kolloquiumsreihe: Prof. Dr. rer. nat. Michael H. Eikerling, Institut für Energie und Klimaforschung, Forschungszentrum Jülich
23238 1585561160

ABGESAGT: MPI Kolloquiumsreihe: Prof. Dr. Frank Noé, FU Berlin, Fachbereich Mathematik und Informatik

MPI Kolloquiumsreihe: Prof. Dr. Frank Noé, FU Berlin, Fachbereich Mathematik und Informatik
23236 1586163103

ABGESAGT: MPI Kolloquiumsreihe: Dr. Klaus Lackner, Arizona State University, Center for Negative Carbon Emissions, Ira A. Fulton Schools of Engineering

MPI Kolloquiumsreihe: Dr. Klaus Lackner, Arizona State University, Center for Negative Carbon Emissions, Ira A. Fulton Schools of Engineering
24234 1588581955

VERSCHOBEN: MPI Kolloquiumsreihe: Prof. Diethard Mattanovich, Institut für Mikrobiologie und Mikrobielle Biotechnologie, Universität für Bodenkultur Wien

MPI Kolloquiumsreihe: Prof. Diethard Mattanovich, Institut für Mikrobiologie und Mikrobielle Biotechnologie, Universität für Bodenkultur Wien
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