MPI Colloquia Series: Prof. Dr. Helmut Cölfen, Non-classical crystallization of organic molecules

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MPI Colloquia Series: Prof. Dr. Helmut Cölfen, Non-classical crystallization of organic molecules

  • Date: May 9, 2019
  • Time: 16:00 - 17:00
  • Speaker: Prof. Dr. Helmut Cölfen
  • Department of Chemistry, University Konstanz
  • Location: Max Planck Institute Magdeburg
  • Room: Big Seminar Room "Prigogine"
  • Contact: sek-pcg@mpi-magdeburg.mpg.de

The Max Planck Institute Magdeburg invites you to its series of colloquia. Top-class scientists, invited by the Max Planck Institute Magdeburg, give a survey of their research work. Everybody who is interested, is invited to attend.


Non-classical crystallization of organic molecules

Non-classical nucleation and crystallization are important alternative pathways to classical nucleation theory (CNT) and the classical layer-by-layer crystal growth according to the Kossel model. In this lecture, the basic concepts of non-classical nucleation as well as non-classical crystallization are introduced and applied to organic molecules. Non-classical nucleation involves pre-nucleation cluster (PNC) species, which were found for all amino acids. In this context, especially the two-step resp. multi-step nucleation will be discussed, which is observed especially for proteins. In this case, liquid precursor phases to crystallization are observed. These can be temporarily stabilized by polymers and a few examples for amino acids and an organic pigment show what is possible beyond the limitations of classical crystallization models. Liquid precursors also play a role for pharmaceutical molecules as will be shown for the well-known pain killer Ibuprofen. These examples demonstrate the application potential of non-classical crystallization approaches.




 
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