Job offer from March 26, 2021
The Molecular Biology team in the Department of Bioprocess Engineering at the Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, is inviting applications for a master thesis in the field of molecular virology of influenza A virus.
Field of study
Influenza A virus (IAV) infections may lead to a potential pandemic. With various strains in circulation, it is essential to develop novel antiviral therapeutics to prevent any development of resistance to currently available antiviral drugs. Defective interfering particles (DIPs) are naturally occurring mutants derived from IAV, carry a large internal deletion in the genome, making them replication-defective. These particles interfere with the replication of IAV, hence regarded as promising antivirals; however, the exact mechanisms of interference remain unknown. Recently, we discovered OP7, a novel DIP harboring multiple point mutations instead of a large internal deletion in the viral genome (see journal article). We show that OP7 is a superior candidate for antiviral therapy compared to conventional DIPs. Therefore, it is essential to understand the various aspects of interference used by OP7 against the standard Influenza A virus.
The topic of the master thesis is “The role of mutated OP7-M1/M2 proteins in interference with standard influenza A virus”.
- Bachelor’s or Master’s degree in Molecular biology, Molecular medicine, Biochemistry, Genetics, Biotechnology, or related fields
- Highly motivated, keen on learning with good scientific oral and written skills
- Optional: experience with aseptic handling of cell culture and a background in molecular cloning
We are happy to have you in our group as soon as possible.
A contract for “Studentische Hilfskraft”/”Hilfswissenschaftler" (20 h per month) is possible.
Kindly send your application along with C.V., letter of motivation, certificates and reference letters via e-mail to:
Tanya Dogra, M.Sc.
The Max Planck Society is committed to increasing the number of individuals with disabilities in its workforce and therefore encourages applications from such qualified individuals. Furthermore, the Max Planck Society seeks to increase the number of women in those areas where they are underrepresented and therefore explicitly encourages women to apply.
Please note the information regarding storage of personal data.