Mathematical modeling plays a crucial role in analyzing and understanding biological systems. Even in well-established culture systems for manufacturing of biologicals there is much to be learned about the molecular biological properties of production cell lines, the dynamics of cell growth and product formation, and the complex interaction of cells with their physicochemical environment in a bioreactor. Combined with results from extensive experimental investigations ranging from the cellular to the bioprocess level, mathematical models not only support the detailed analysis of the systems' behavior, but also the design and optimization of the overall process.

Subprojects:

Mathematical Modeling of Cellular Systems
SysLogics - Modelling of Central Metabolism
Modeling the Dynamics of Influenza Virus Replication in Mammalian Cells
Dynamics of Glycolysis and Citric Acid Cycle in Mammalian Cells


Mathematical Modeling, Simulation and Control of Bioprocesses
Model-based Investigation of Influenza Virus Replication in Mammalian Cell Culture



This project is cooperation between the Bioprocess Engineering group at the MPI and the Bioprocess Engineering group at the Otto-von-Guericke-University, Magdeburg.

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