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Journal Article (102)

2024
Journal Article
Göbel, S.; Pelz, L.; Silva, C. A. T.; Brühlmann, B.; Hill, C.; Altomonte, J.; Kamen, A.; Reichl, U.; Genzel, Y.: Production of recombinant vesicular stomatitis virus-based vectors by tangential flow depth filtration. Applied Microbiology and Biotechnology 108 (1), 240 (2024)
Journal Article
Pelz, L.; Dogra, T.; Marichal-Gallardo, P.; Hein, M. D.; Hemissi, G.; Kupke, S. Y.; Genzel, Y.; Reichl, U.: Production of antiviral “OP7 chimera” defective interfering particles free of infectious virus. Applied Microbiology and Biotechnology 108, pp. 1 - 15 (2024)
Journal Article
Zinnecker, T. M.; Badri, N.; Araujo, D.; Thiele, K.; Reichl, U.; Genzel, Y.: From single‐cell cloning to high‐yield influenza virus production – implementing advanced technologies in vaccine process development. Engineering in Life Sciences, 2300245 (2024)
2023
Journal Article
Dogra, T.; Pelz, L.; Boehme, J. D.; Küchler, J.; Kershaw, O.; Marichal-Gallardo, P.; Baelkner, M.; Hein, M. D.; Gruber, A. D.; Benndorf, D. et al.; Genzel, Y.; Bruder, D.; Kupke, S. Y.; Reichl, U.: Generation of “OP7 chimera” defective interfering influenza A particle preparations free of infectious virus that show antiviral efficacy in mice. Scientific Reports 13, 20936 (2023)
Journal Article
Göbel, S.; Jaén, K. E.; Dorn, M.; Neumeyer, V.; Jordan, I.; Sandig, V.; Reichl, U.; Altomonte, J.; Genzel, Y.: Process intensification strategies toward cell culture‐based high‐yield production of a fusogenic oncolytic virus. Biotechnology and Bioengineering 120 (9), pp. 2639 - 2657 (2023)
Journal Article
Göbel, S.; Jaén, K. E.; Fernandes, R. P.; Reiter, M.; Altomonte, J.; Reichl, U.; Genzel, Y.: Characterization of a quail suspension cell line for production of a fusogenic oncolytic virus. Biotechnology and Bioengineering 120, pp. 3335 - 3346 (2023)
Journal Article
Hein, M. D.; Kazenmaier, D.; van Heuvel, Y.; Dogra, T.; Cattaneo, M.; Kupke, S. Y.; Stitz, J.; Genzel, Y.; Reichl, U.: Production of retroviral vectors in continuous high cell density culture. Applied Microbiology and Biotechnology 107, pp. 5947 - 5961 (2023)
Journal Article
van Heuvel, Y.; Schatz, S.; Hein, M.; Dogra, T.; Kazenmaier, D.; Tschorn, N.; Genzel, Y.; Stitz, J.: Novel suspension retroviral packaging cells generated by transposition using transposase encoding mRNA advance vector yields and enable production in bioreactors. Frontiers in Bioengineering and Biotechnology 11, 1076524 (2023)
2022
Journal Article
Göbel, S.; Kortum, F.; Chavez, K. J.; Jordan, I.; Sandig, V.; Reichl, U.; Altomonte, J.; Genzel, Y.: Cell-line screening and process development for a fusogenic oncolytic virus in small-scale suspension cultures. Applied Microbiology and Biotechnology 106, pp. 4945 - 4961 (2022)
Journal Article
Küchler, J.; Püttker, S.; Lahmann, P.; Genzel, Y.; Kupke, S. Y.; Benndorf, D.; Reichl, U.: Absolute quantification of viral proteins during single-round replication of MDCK suspension cells. Journal of Proteomics 259, 104544 (2022)
Journal Article
Möckel, M.; Baldok, N.; Walles, T.; Hartig, R.; Müller, A. J.; Reichl, U.; Genzel, Y.; Walles, H.; Wiese-Rischke, C.: Human 3D Airway Tissue Models for Real-Time Microscopy: Visualizing Respiratory Virus Spreading. Cells 11 (22), 3634 (2022)
Journal Article
Offersgaard, A.; Duarte Hernandez, C. R.; Pihl, A. F.; Venkatesan, N. P.; Krarup, H.; Lin, X.; Reichl, U.; Bukh, J.; Genzel, Y.; Gottwein, J. M.: High-Titer Hepatitis C Virus Production in a Scalable Single-Use High Cell Density Bioreactor. Vaccines 10 (2), 249 (2022)
Journal Article
Rodrigues Correia Ramos, J.; Bissinger, T.; Genzel, Y.; Reichl, U.: Impact of Influenza A Virus Infection on Growth and Metabolism of Suspension MDCK Cells Using a Dynamic Model. Metabolites 12 (3), 239 (2022)
2021
Journal Article
Bissinger, T.; Wu, Y.; Marichal-Gallardo, P.; Riedel, D.; Liu, X.; Genzel, Y.; Tan, W.; Reichl, U.: Towards integrated production of an influenza A vaccine candidate with MDCK suspension cells. Biotechnology and Bioengineering 118 (10), pp. 3996 - 4013 (2021)
Journal Article
Gränicher, G.; Babakhani, M.; Göbel, S.; Jordan, I.; Marichal-Gallardo, P.; Genzel, Y.; Reichl, U.: A high cell density perfusion process for Modified Vaccinia virus Ankara production: process integration with inline DNA digestion and cost analysis. Biotechnology and Bioengineering 118 (12), pp. 4720 - 4734 (2021)
Journal Article
Gränicher, G.; Tapia, F.; Behrendt, I.; Jordan, I.; Genzel, Y.; Reichl, U.: Production of Modified Vaccinia Ankara Virus by Intensified Cell Cultures: A Comparison of Platform Technologies for Viral Vector Production. Biotechnology Journal 16 (1), e2000024 (2021)
Journal Article
Hein, M. D.; Arora, P.; Marichal-Gallardo, P.; Winkler, M.; Genzel, Y.; Pöhlmann, S.; Schughart, K.; Kupke, S. Y.; Reichl, U.: Cell culture-based production and in vivo characterization of purely clonal defective interfering influenza virus particles. BMC Biology 19 (1), 91 (2021)
Journal Article
Hein, M. D.; Chawla, A.; Cattaneo, M.; Kupke, S. Y.; Genzel, Y.; Reichl, U.: Cell culture–based production of defective interfering influenza A virus particles in perfusion mode using an alternating tangential flow filtration system. Applied Microbiology and Biotechnology 105, pp. 7251 - 7264 (2021)
Journal Article
Hein, M. D.; Kollmus, H.; Marichal-Gallardo, P.; Püttker, S.; Benndorf, D.; Genzel, Y.; Schughart, K.; Kupke, S. Y.; Reichl, U.: OP7, a novel influenza A virus defective interfering particle: production, purification, and animal experiments demonstrating antiviral potential. Applied Microbiology and Biotechnology 105 (1), pp. 129 - 146 (2021)
Journal Article
Offersgaard, A.; Duarte Hernandez, C. R.; Pihl, A. F.; Costa, R.; Venkatesan, N. P.; Lin, X.; Van Pham, L.; Feng, S.; Fahnøe, U.; Scheel, T. K. H. et al.; Ramirez, S.; Reichl, U.; Bukh, J.; Genzel, Y.; Gottwein, J. M.: SARS-CoV-2 Production in a Scalable High Cell Density Bioreactor. Vaccines 9 (7), 706 (2021)
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