Search results

Journal Article (17)

2019
Journal Article
Kupke, S. Y.; Riedel, D.; Frensing, T.; Zmora, P.; Reichl, U.: A Novel Type of Influenza A Virus-Derived Defective Interfering Particle with Nucleotide Substitutions in Its Genome. Journal of Virology 93 (4), 01786-18 (2019)
Journal Article
Laske, T.; Bachmann, M.; Dostert, M.; Karlas, A.; Wirth, D.; Frensing, T.; Meyer, T. F.; Hauser, H.; Reichl, U.: Model-based analysis of influenza A virus replication in genetically engineered cell lines elucidates the impact of host cell factors on key kinetic parameters of virus growth. PLoS Computational Biology 15 (4), e1006944 (2019)
2016
Journal Article
Bachmann, M.; Breitwieser, T.; Lipps, C.; Wirth, D.; Jordan, I.; Reichl, U.; Frensing, T.: Impaired antiviral response of adenovirus-transformed cell lines supports virus replication. Journal of General Virology 97 (2), pp. 293 - 298 (2016)
Journal Article
Frensing, T.; Kupke, S. Y.; Bachmann, M.; Fritzsche, S.; Gallo Ramirez, L. E.; Reichl, U.: Influenza virus intracellular replication dynamics, release kinetics, and particle morphology during propagation in MDCK cells. Applied Microbiology and Biotechnology 100 (16), pp. 7181 - 7192 (2016)
Journal Article
Laske, T.; Heldt, F. S.; Hoffmann, H.; Frensing, T.; Reichl, U.: Modeling the intracellular replication of influenza A virus in the presence of defective interfering RNAs. Virus Research 213, pp. 90 - 99 (2016)
Journal Article
Laske, T.; Heldt, S.; Hoffmann, H.; Frensing, T.; Reichl, U.: Reprint of “Modeling the intracellular replication of influenza A virus in the presence of defective interfering RNAs. Virus Research 218, pp. 86 - 95 (2016)
2015
Journal Article
Frensing, T.: Defective interfering viruses and their impact on vaccines and viral vectors. Biotechnology Journal 10 (5), pp. 681 - 689 (2015)
Journal Article
Heldt, F. S.; Kupke, S. Y.; Dorl, S.; Frensing, T.; Reichl, U.: Single-cell analysis and stochastic modelling unveil large cell-to-cell variability in influenza A virus infection. Nature Communications 6, 8938 (2015)
2014
Journal Article
Frensing, T.; Pflugmacher, A.; Bachmann, M.; Peschel, B.; Reichl, U.: Impact of defective interfering particles on virus replication and antiviral host response in cell culture-based influenza vaccine production. Applied Microbiology and Biotechnology 98 (21), pp. 8999 - 9008 (2014)
2013
Journal Article
Frensing, T.; Heldt, S.; Pflugmacher, A.; Behrendt, I.; Jordan, I.; Flockerzi, D.; Genzel, Y.; Reichl, U.: Continuous Influenza Virus Production in Cell Culture Shows a Periodic Accumulation of Defective Interfering Particles. PLoS One 8 (9), p. e72288 (2013)
Journal Article
Genzel, Y.; Frensing, T.; Reichl, U.: Herstellung moderner Grippeimpfstoffe: Zellkultur statt Hühnerei. Chemie in unserer Zeit 47 (1), pp. 12 - 22 (2013)
Journal Article
Heldt, S.; Frensing, T.; Pflugmacher, A.; Gröpler, R.; Peschel, B.; Reichl, U.: Multiscale Modeling of Influenza A Virus Infection Supports the Development of Direct-Acting Antivirals. PLoS Computational Biology 9 (11), p. e1003372 (2013)
2012
Journal Article
Heldt, F. S.; Frensing, T.; Reichl, U.: Modeling the intracellular dynamics of influenza virus replication to understand the control of viral RNA synthesis. Journal of Virology 86 (15), pp. 7806 - 7817 (2012)
Journal Article
Seitz, C.; Isken, B.; Heynisch, B.; Rettkowski, M.; Frensing, T.; Reichl, U.: Trypsin promotes efficient influenza vaccine production in MDCK cells by interfering with the antiviral host response. Applied Microbiology and Biotechnology 93 (2), pp. 601 - 611 (2012)
2011
Journal Article
Frensing, T.; Seitz, C.; Heynisch, B.; Patzina, C.; Kochs, G.; Reichl, U.: Efficient influenza B virus propagation due to deficient interferon-induced antiviral activity in MDCK cells. Vaccine 29 (41), pp. 7125 - 7129 (2011)
2010
Journal Article
Heynisch, B.; Frensing, T.; Heinze, K.; Seitz, C.; Genzel, Y.; Reichl, U.: Differential activation of host cell signaling pathways through infection with two variants of influenza A /Puerto Rico /8/34 (H1N1) in MDCK cells. Vaccine 28 (51), pp. 8210 - 8218 (2010)
Journal Article
Seitz, C.; Frensing, T.; Höper, D.; Kochs, G.; Reichl, U.: High yields of Influenza A virus in MDCK cells are promoted by an insufficient IFN-induced antiviral state. Journal of General Virology 91 (7), pp. 1754 - 1763 (2010)

Meeting Abstract (1)

2018
Meeting Abstract
Kupke, S. Y.; Riedel, D.; Frensing, T.; Zmora, P.; Reichl, U.: Single-cell analysis uncovers a novel influenza A virus-derived defective interfering particle for antiviral therapy. In Vaccine Technology VII, 133. Vaccine Technology VII, Mont Tremblant, Canada, June 17, 2018 - June 22, 2018. (2018)

Talk (17)

2017
Talk
Laske, T.; Bachmann, M.; Dostert, M.; Karlas, A.; Wirth, D.; Frensing, T.; Reichl, U.: Model-based characterization of influenza A virus production in genetically engineered cell lines elucidates changes in virus replication. 3rd Workshop on Virus Dynamics, Heidelberg, Germany (2017)
2016
Talk
Kupke, S. Y.; Heldt, S.; Frensing, T.; Reichl, U.: Single-Cell Analysis of Influenza A Virus-Infected Cells. 26th Annual Meeting of the Society for Virology, Münster, Germany (2016)
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