I am interested in defective
interfering particles (DIPs) of Influenza virus A and its influence on
bioprocesses. The aim of my first project is to understand the dynamics of
influenza A virus DIP replication and the mechanism of interference on a
molecular level. The findings can lead to new options to increase process
yields in influenza vaccine production.
Due to their interference with standard virus, DIPs have the potential
to be used as antivirals. In my second project I want to deliver approaches to
manufacture such an antiviral, previously grown in eggs, in chemically
defined suspension culture (Wasik et al.
Wasik MA, Eichwald L, Genzel Y, Reichl
U (2017) Cell culture-based production of defective interfering
particles for influenza antiviral therapy. Appl Microbiol Biotechnol. doi: