Address

Felipe Tapia

Santorstr. 1

39106 Magdeburg

Links

Felipe Tapia

Felipe Tapia

Felipe Tapia

Phone:

  • +49 391 6110 207

Email:

Room:

N0.15

Main Focus

My main goal is to develop continuous production systems of cell culture-derived viral vaccines, with focus in Modified Vaccinia Ankara (MVA) virus and influenza virus. Continuous systems are known to be more efficient than batch, but previous studies have shown that virus replication in continuous mode is limited by the accumulation of defective interfering particles (DIPs). Also, continuous virus production has the risk of unwanted viral antigenic mutations that can arise after many days of virus replication. To solve these issues, I have been working in the production of a stable virus such as MVA in a two-stage continuous stirred tank bioreactor that can be used for recombinant vaccines production. We have also design and constructed a novel process for influenza whole-virus production that is based on a plug-flow tubular bioreactor system (patent submitted). Both systems, are good candidates to be used in continuous production of cell culture-derived vaccines. 

    Curriculum Vitae


    Higher Education:

    • M.Sc (w. Hons) in Advanced Materials and Processes, Friedrich-Alexander Universität Erlangen-Nürnberg, Germany, 2012. Focus in tissue engineering, biomaterials.
    • Diploma in Chemical Engineering, Universidad Técnica Federico Santa María, Valparaíso, Chile, 2010. Focus in process engineering.


    Publications:

    • 2016 Tapia F, Vazquez-Ramirez D, Genzel Y, Reichl U. Bioreactors for high cell density and continuous multi-stage cultivations: options for process intensification in cell culture-based viral vaccine production. Applied Microbiology and Biotechnology. Link
    • 2014 Diba M, Goudouri OM, Tapia F, Boccaccini AR. Magnesium-containing bioactive polycrystalline silicate-based ceramics and glass-ceramics for biomedical applications. Current Opinion in Solid State and Materials Science. Link
    • 2013 Tapia F, Vogel T, Behrendt I, Genzel Y, Hirschel M, Gangemi JD, Reichl U. Production of high-titer human influenza A virus with adherent and suspension MDCK cells cultured in a single-use hollow fiber bioreactor. Vaccine. Link
    • 2013 Diba M, Tapia F, Strobel L, Boccaccini AR. Magnesium-containing bioactive glasses for biomedical applications. International Journal of Applied Glass Science. Link


    Organizational Unit (Department, Group, Facility):

    • Bioprocess Engineering
    • Max Planck Institute for Dynamics of Complex Technical Systems
     
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