Address

Max-Planck-Institut für Dynamik komplexer technischer Systeme

apl. Prof. Dr. rer. nat. Heike Lorenz

apl. Prof. Dr. rer. nat. Heike Lorenz

apl. Prof. Dr. rer. nat. Heike Lorenz

apl. Prof. Dr. rer. nat. Heike Lorenz

Phone:

  • +49 391 6110 293

Fax:

  • +49 391 6110 524

Email:

Room:

N2.11

Main Focus

  • Crystallization as a process for separation and product design
    ·
    Solid/liquid equilibria (phase diagrams)

    ·
    Crystallization kinetics

    · Online, inline and offline measurement techniques for studying crystallization processes and for process monitoring
  • Separation and purification of fine chemicals 
    · Enantiomers & isomers in general, biogenic materials
    · Innovative concepts of crystallization-based separation (e. g. integrated/hybrid processes, Preferential Crystallization, fractional crystallization) 
  • Thermal Analysis, Calorimetry, X-Ray Powder Diffraction

Curriculum Vitae

Personal Facts

  • apl. Professor at Otto von Guericke University (OvGU) Magdeburg (2010)
  • Habilitation at OvGU Magdeburg (2004), Thesis on “Heterogeneous processes on the example of combustion of solids and crystallization from solution”
  • Invited lecturer at Rouen University/France, Faculté des Sciences et des Techniques, Département Chimie (2002, 2004)
  • Senior scientist at the Max Planck Institute for Dynamics of Complex Technical Systems, Dept. of Physical and Chemical Foundations of Process Engineering (since Oct. 1998), Team Leader Crystallization
  • Visiting researcher at the International Flame Research Foundation, IJmuiden/The Netherlands (1998)
  • Scientific coworker at the Chemistry Department of the Otto von Guericke University Magdeburg, Technical Chemistry (1992-1998)
  • Ph.D. studies at Otto von Guericke University (OvGU) Magdeburg (1988-1992), Thesis on “Investigation of fluidized bed combustion of solid fuels by means of gaspotentiometric solid electrolyte oxygen sensors”
  • Studies of Chemistry at Freiberg University of Mining and Technology (1983-1988), Diploma thesis on “Thermoanalytical and thermokinetic studies on melts of selected salt hydrates”

    Scientific Awards/ Honours/ Memberships

      • Elected Chairwoman of Board “Crystallization” of the DECHEMA/VDI - GVC's ProcessNet (2009 - 2014)
      • Elected Member of the Scientific Council of the Max Planck Society (Chemistry, Physics and Technology Section) (2010-2013)
      • “Research Award for Applied Research” of the state of Saxony-Anhalt (2008)
      • Appointed member of Board “Crystallization” of the Society of Process and Chemical Engineering (GVC) of the Association of German Engineers (VDI) (since 2004)
      • Award of the DECHEMA e.V. for Young University Lecturers in Technical Chemistry (1999) 
      • Medal “Georgius-Agricola” of the Freiberg University of Mining and Technology (1988)
      • Grant of the state of Saxony-Anhalt to support Habilitation (1998)
      • Member of the Society of German Chemists (GDCh) (since 1988), the DECHEMA e.V. (since 2000), the working party of Process Analytics (since 2005) and the GEFTA (since 2013)

      Publications (selected)


      2014-2013

      /46/    Lorenz, H., Seidel-Morgenstern, A.: Processes to separate enantiomers. Angew. Chem. Int. Ed. 53 (2014), pp. 1218–1250; Angew. Chem. 126 (2014), pp. 1240–1274.

      /45/   Binev, D., Taratin, N., Kotelnikova, E., Seidel-Morgenstern, A., Lorenz, H.: Solubility equilibria and crystallographic characterization of the L-threonine/L-allo-threonine system. Part 1: Solubility equilibria in the threonine diastereomeric system. Cryst. Growth Des. 14 (2014), pp. 367
      –373.


      /44/   Borchert, C., Temmel, E., Eisenschmidt, H., Lorenz, H., Seidel-Morgenstern, A., Sundmacher, K.: Image-based in-situ identification of face specific crystal growth rates from crystal populations. Cryst. Growth Des. 14 (2014), pp. 952–971.

      /43/    Horosanskaia, E., Seidel-Morgenstern, A., Lorenz, H.: Investigation of drug polymorphism: Case of artemisinin.
      Thermochimica Acta 578 (2014), pp. 74–81
      .

      /42/   Lorenz, H., Le Minh, T., Kaemmerer, H., Buchholz, H., Seidel-Morgenstern, A.: Exploitation of shifts of eutectic compositions in crystallization-based enantioseparation. Chem. Eng. Res. Des., 91 (2013), pp.1890-1902.

      /41/    Lorenz, H.: Solubility and Solution Equilibria in Crystallization, In: Beckmann, W. (Ed.): Crystallization: Basic Concepts and Industrial Applications, Wiley-VCH, Weinheim 2013, pp. 35–74.

      /40/   Lorenz, H. and Beckmann, W.: Purification by Crystallization, In: Beckmann, W. (Ed.): Crystallization: Basic Concepts and Industrial Applications, Wiley-VCH, Weinheim 2013, pp. 129–148.

      /39/  Temmel, E., Wloch, S., Müller, U., Grawe, D., Eilers, R., Lorenz, H., Seidel-Morgenstern, H.: Separation of systems forming solid solutions using counter-current crystallization. Chem. Eng. Sci., 104 (2013), pp.662-673.

      /38/   Temmel, E., Wloch, S., Müller, U., Grawe, D., Eilers, R., Lorenz, H., Seidel-Morgen-stern, A.: Aufreinigung durch mehrstufige Gegenstromkristallisation zur Herstellung hochreiner Pharmazeutika. Chem. Ing. Tech. 85 (2013), S. 1581-1588.

      /37/   Sistla, V. S., Lorenz, H., Seidel-Morgenstern, A.: Crystallization-based resolution process for the 2,3-dibenzoyl-D/L-tartrate salts of D-/L-serine benzyl ester. Cryst. Growth Des. 13 (2013), pp. 2548–2556.

      /36/  Robl, S., Gou, L., Gere, A., Sordo, M., Lorenz, H., Mayer, A., Pauls, C., Leonhard, K., Bardow, A., Seidel-Morgenstern, A., Schaber, K.: Chiral separation by combining pertraction and preferential crystallization. Chem. Eng. Process. 67 (2013), pp. 80–88.

      /35/  Kaemmerer, H., Seidel-Morgenstern, A., Lorenz, H.: Chiral separation of systems of high eutectic composition by a combined process: Case study of serine enantiomers. Chem. Eng. Process 67 (2013), pp. 71-79.

      /34/  
      Balawejder, M., Mossety-Leszczak, B., Poplewska, I., Lorenz, H., Seidel-Morgenstern, A., Piatkowski, W., Antos, D.: Modeling and predictions of solid–liquid equilibria for citalopram oxalate as a representative of a solid solution forming system. Fluid Phase Equilibr. 346 (2013), pp. 8–19
      .

      2012-2009

      /33/   Gou, L., Lorenz, H., Seidel-Morgenstern, A.: Investigation of a chiral additive used in preferential crystallization. Cryst. Growth Des. 12 (2012), pp. 5197–5202.

      /32/   Taratin, N., Lorenz, H., Kotelnikova, E., Glikin, A., Galland, A., Dupray, V., Coquerel, G., Seidel-Morgenstern, A.: Mixed crystals in chiral organic systems on the example of an ethanolamine salt of 3-chloromandelic acid. Cryst. Growth Des. 12 (2012), pp. 5882-5888.

      /31/   Balawejder, M., Kiwala, D., Lorenz, H., Seidel-Morgenstern, A., Piatkowski, W., Antos, D.: Resolution of a diastereomeric salt of citalopram by multistage crystallization. Cryst. Growth. Des. 12 (2012), pp. 2557–2566.

      /30/   von Langermann, J., Kaspereit, M., Shakeri, M., Lorenz, H., Hedberg, M., Jones, M. J., Larson, K., Herrschend, B., Arnell, R., Temmel, E., Bäckvall, J.-E., Kienle, A., Seidel-Morgenstern, A.: Design of an integrated process of chromatography, crystallization and racemization for the resolution of 2’,6’-pipecoloxylidide (PPX). Org. Proc. Res. Dev. 16 (2012), pp. 343–352.

      29/    Kaemmerer, H., Horvath, Z., Lee, J. W., Kaspereit, M., Arnell, R., Hedberg, M., Herrschend, B., Jones, M. J., Larson, K., Lorenz, H. Seidel-Morgenstern, A.: Separation of racemic bicalutamide by an optimized combination of continuous chromatography and selective crystallization. Org. Proc. Res. Dev. 16 (2012), pp. 331–342.

      /28/    Lorenz, H., Ulrich, J.: Meißener Klausurtagung: Positionierung des Fachausschusses Kristallisation zu Zukunftsthemen. Chem. Ing. Tech. 83 (2011), S. 2089–2092.

      /27/   Sistla, V. S., von Langermann, J., Lorenz, H., Seidel-Morgenstern, A.: Analysis and comparison of commonly used acidic resolving agents in diastereomeric salt resolution - examples for DL-serine. Cryst. Growth Des. 11 (2011), pp. 3761–3768.

      /26/   Lorenz, H., von Langermann, J., Sadiq, G., Seaton, C., Davey, R., Seidel-Morgenstern, A.: The phase behaviour and crystallisation of 2-chloromandelic acid: the crystal structure of the pure enantiomer and the behaviour of its metastable conglomerate. Cryst. Growth Des. 11 (2011), pp. 1549–1556.

      /25/  Tulashie, S., Lorenz, H., von Langermann, J., Seidel-Morgenstern, A.:  Chiral task-specific solvents for mandelic acid and their impact on solution thermodynamics and crystallization kinetics. Cryst. Growth Des. 11 (2011), pp. 240–246.

      /24/  Gou, L., Robl, S., Leonhard, K., Lorenz, H., Sordo, M., Butka, A., Kesselheim, S., Wolff, M., Seidel-Morgenstern, A., Schaber, K.: A hybrid process for chiral separation of compound-forming systems. Chirality 23 (2011), pp. 118–127.

      /23/    Kaemmerer, H., Jones, M. J., Lorenz, H., Seidel-Morgenstern, A.: Selective crystallisation of a chiral compound-forming system – Solvent screening, SLE determination and process design. Fluid Phase Equilibr. 296 (2010), pp. 192–205.

      /22/    Le Minh, T., von Langermann, J., Lorenz, H., Seidel-Morgenstern, A.: Enantiomeric 3-chloromandelic acid system: Binary melting point phase diagram, ternary solubility phase diagrams and polymorphism. J. Pharm. Sci. 99 (2010), pp. 4084–4095.

      /21/    von Langermann, J., Le Minh, T., Lorenz, H., Seidel-Morgenstern, A.: Kombination von Biokatalyse und Kristallisation zur Darstellung enantiomerenreiner Mandelsäurederivate. Chem. Ing. Tech. 82 (2010), S. 93–99.

      /20/   Polenske, D., Lorenz, H., Seidel-Morgenstern, A.: The binary phase diagram of propranolol hydrochloride and crystallization based enantioseparation. J. Pharm. Sci. 99 (2010), pp. 1762–1773.

      /19/    Schotte, E., Lemin, B., Lorenz, H., Rau, H.: Gas Potentiometry – Oxygen Based Redox Process Diagnostics in High Temperature Environment. In: Lackner, M., Winter, F., Agarwal, A. K. (Eds.): Handbook on Combustion, Vol. 2: Combustion Diagnostics and Pollutants, Wiley VCH, Weinheim, 2010, pp. 89–123.

      /18/   Kaemmerer, H., Lorenz, H., Seidel-Morgenstern, A.: Alternatives Verfahren zur Racemattrennung verbindungsbildender Systeme mittels Kristallisation. Chem. Ing. Tech. 12 (2009), S. 1955–1965.

      /17/   Tulashie, S., Lorenz, H., Seidel-Morgenstern, A.: Potential of chiral solvents for enantioselective crystallization. 2. Evaluation of kinetic effects. Cryst. Growth Des. 9 (2009), pp. 2387–2392.

      /16/    Kaemmerer, H., Lorenz, H., Black, S., Seidel-Morgenstern, A.: Study of system thermodynamics and the feasibility of chiral resolution of the polymorphic system of malic acid enantiomers and its partial solid solutions. Cryst. Growth Des. 9 (2009), pp. 1851–1862.

      /15/    Polenske, D., Lorenz, H., Seidel-Morgenstern, A.: Potential of different techniques  of preferential crystallization for enantioseparation of racemic compound forming systems. Chirality 21 (2009), pp. 728–737.

      2008-2005

      /14/   Lorenz, H., Kaemmerer, H. (Eds.): BIWIC 2008: 15th International Workshop on Industrial Crystallization. Shaker Verlag, Aachen, 2008

      /13/   Tulashie, S., Lorenz, H., Hilfert, L., Edelmann, F. T., Seidel-Morgenstern, A.: Potential of chiral solvents for enantioselective crystallization. 1. Evaluation of thermodynamic effects. Cryst. Growth Des. 8 (2008), pp. 3408–3414.

      /12/    Polenske, D., Lorenz, H., Seidel-Morgenstern, A.: Separation of propranolol hydrochloride enantiomers by preferential crystallization: Thermodynamic basis and experimental verification. Cryst. Growth Des. 7 (2007), pp. 1628–1634.

      /11/    Gedicke, K., Kaspereit, M., Beckmann, W., Budde, U., Lorenz, H., Seidel-Morgenstern, A.: Conceptual design and feasibility study of combining continuous chromatography and crystallization for stereoisomer separations. Chem. Eng. Res. Des. 85 (2007), pp. 928–936.

      /10/    Lorenz, H., Polenske, D., Seidel-Morgenstern, A.: Application of preferential crystallization to resolve racemic compounds in a hybrid process. Chirality 18 (2006), pp. 828–840.

      /9/    Polenske, D., Elsner, M. P., Lorenz, H., Seidel-Morgenstern, A.: Alternative Einsatz-möglichkeiten der „Bevorzugten Kristallisation“ zur Enantiomerentrennung. Chem. Ing. Tech. 78 (2006), S. 1101–1110.

      /8/    Lorenz, H., Perlberg, A., Sapoundjiev, D., Elsner, M. P., Seidel-Morgenstern, A.: Crystallization of enantiomers (Review). Chem. Eng. Process. 45 (2006), pp. 863–873.

      /7/    Beckmann, W., Lorenz, H.: Partial miscibility of organic compounds in the solid state – the case of two epimers of a diastereomer. Chem. Eng. Technol. 29 (2006), pp. 226–232.

      /6/    Perlberg, A., Lorenz, H., Seidel-Morgenstern, A.: Crystal Growth Kinetics via Isothermal Seeded Batch Crystallization: Evaluation of Measurement Techniques and Application to Mandelic Acid in Water. Ind. Eng. Chem. Res. 44 (2005), pp. 1012–1020.

      2004-2001


      /5/    Alvarez Rodrigo, A., Lorenz, H., Seidel-Morgenstern, A.: Online Monitoring of Preferential Crystallization of Enantiomers. Chirality 16 (2004), pp. 499–508

      /4/    Lorenz, H., Seidel-Morgenstern, A.: A contribution to the mandelic acid phase diagram. Thermochimica Acta 415 (2004), pp. 55–61.

      /3/    Mohan, R., Lorenz, H., Myerson, A.: Solubility Measurement Using Differential Scanning Calorimetry. Ind. Eng. Chem. Res. 41 (2002), pp. 4854–4862.

      /2/    Lorenz, H., Seidel-Morgenstern, A.: Binary and ternary phase diagrams of two enantiomers in solvent systems. Thermochimica Acta 382 (2002), pp. 129–142.

      /1/    Lorenz, H., Sheehan, P., Seidel-Morgenstern, A.: Coupling of simulated moving bed chromatography and fractional crystallisation for efficient enantioseparation. Journal of Chromatography A 908 (2001), pp. 201–214.

      Organizational Unit (Department, Group, Facility):

      • Max Planck Institute for Dynamics of Complex Technical Systems
      • Physical and Chemical Foundations of Process Engineering
       
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