Address

Max-Planck-Institut für Dynamik komplexer technischer Systeme

apl. Prof. Dr. rer. nat. Heike Lorenz

apl. Prof. Dr. rer. nat. Heike Lorenz

apl. Prof. Dr. rer. nat. Heike Lorenz

apl. Prof. Dr. rer. nat. Heike Lorenz

Phone:

  • +49 391 6110 293

Fax:

  • +49 391 6110 524

Email:

Room:

N2.11

Main Focus

  • Crystallization as a process for separation and product design
    • Phase equilibria and phase transitions
    • Crystallization kinetics
    • Techniques for studying crystallization processes and for process monitoring
    • Process design
  • Separation and purification of fine chemicals, large scale industrial products and renewable resources
    • Innovative concepts of crystallization-based separation (e. g. integrated processes, Preferential Crystallization, fractional crystallization)
    • Enantiomers, biogenic materials and other multicomponent mixtures (e. g. plant extracts)

  • Thermal Analysis, Calorimetry, X-Ray Powder Diffraction

Curriculum Vitae

Personal Facts

  • apl. Professor at Otto von Guericke University (OvGU) Magdeburg (since 2010)
  • Habilitation at OvGU Magdeburg (2004), Thesis subjects: heterogeneous processes on the example of combustion of solids and crystallization from solution
  • Invited lecturer at Rouen University/France, Faculté des Sciences et des Techniques, Département Chimie (2002, 2004)
  • Senior scientist at the Max Planck Institute for Dynamics of Complex Technical Systems in Magdeburg, Dept. of Physical and Chemical Foundations of Process Engineering (since 1998), Team Leader Crystallization
  • Visiting researcher at the International Flame Research Foundation, IJmuiden/The Netherlands (1998)
  • Scientist at the Chemistry Department of the OvGU Magdeburg, Technical Chemistry (1992-1998)
  • Ph.D. studies at Otto von Guericke University (OvGU) Magdeburg (1988-1992), Thesis subjects: fluidized bed combustion, inline monitoring of combustion processes
  • Studies of Chemistry at Freiberg University of Mining and Technology (1983-1988), Diploma thesis subject thermoanalytical and thermokinetic studies on melts of selected salt hydrates


Scientific Awards / Honours / Memberships

  • European Federation of Chemical Engineers (EFCE) delegate, Working Party Crystallization (since 2015)
  • Chair of the “Crystallization” board of DECHEMA/VDI/GVC's ProcessNet (2009-2014)
  • Representative of the MPI employees, elected Member of the Scientific Council of the Max Planck Society (Chemistry, Physics and Technology Section) (2010-2013)
  • “Research Award for Applied Research” of the state of Saxony-Anhalt (2008)
  • Appointed member of board “Crystallization” of the Society of Process and Chemical Engineering (GVC) of the Association of German Engineers (VDI) (since 2004)
  • Award of the DECHEMA e.V. for Young University Lecturers in Technical Chemistry (1999)
  • Grant of the state of Saxony-Anhalt to support Habilitation (1998)
  • Medal “Georgius-Agricola” of the Freiberg University of Mining and Technology (1988)
  • Member of the Society of German Chemists (GDCh) (since 1988), the DECHEMA e.V. (since 2000), the working party of Process Analytics (since 2005) and the GEFTA (since 2013)


Publications (2013-2018)

2018

Rekis, T., Berzins, A., Sarcevica, I., Kons, A., Balodis, M., Orola, L., Lorenz, H., Actins, A.: A maze of solid solutions of pimobendan enantiomers: An extraordinary case of polymorph and solvate diversity. Cryst. Growth Des. 18 (2018), pp. 264–273

Kotelnikova, E. N., Isakov, A. I., Lorenz, H.: Thermal deformations of crystal structures formed in the systems of malic acid enantiomers and L-valine−L-isoleucine enantiomers. CrystEngComm 20 (2018), pp. 2562–2572

Lorenz, H., Kaemmerer, H., Polenske, D., Seidel-Morgenstern, A.: Process for enantioseparation of chiral systems with compound formation using two subsequent crystallization steps. Patent EP 09779821.9 (09.08.2018); US 8,992,783 B2 (31.03.2015); WO 2010/025968 A2 (11.03.2010)

Lorenz, H., Temmel, E., Seidel-Morgenstern, A.: Continuous Enantioselective Crystallization of Chiral Compounds. In: Yazdanpanah, N. and Z. Nagy (Eds.): The Handbook of Continuous Crystallization, Royal Society of Chemistry, 2018, in print

Temmel, E., Gänsch, J., Lorenz, H., Seidel-Morgenstern, A. (2018): Measurement and evaluation of the crystallization kinetics of L-asparagine monohydrate in the ternary L-/D-asparagine/water system. Cryst. Growth Des. DOI: 10.1021/acs.cgd.8b01322

Yuan, L. Lorenz, H. (2018): Solvate formation of bis(demethoxy)curcumin: Screening and characterization. Crystals, DOI: 10.3390/cryst8110407

2017

Mangold, M., Khlopov, D., Temmel, E., Lorenz, H., Seidel-Morgenstern, A.: Modelling geometrical and fluid-dynamic aspects of a continuous fluidized bed crystallizer for separation of enantiomers. Chem. Eng. Sci. 160 (2017), pp. 281–290

Kotelnikova, E. N., Isakov, A. I., Lorenz, H.: Non-equimolar discrete compounds in binary chiral systems of organic substances. CrystEngComm 19 (2017), pp. 1851–1869

Rekis, T., Berzins, A., Orola, L., Holczbauer, T., Actins, A., Seidel-Morgenstern, A., Lorenz, H.: Single enantiomer’s urge to crystallize in centrosymmetric space groups: solid solutions of phenylpiracetam. Cryst. Growth Des. 17 (2017), pp. 1411–1418

Kort, A.-K., Lorenz, H., Seidel-Morgenstern, A.: Melting behavior and solubility equilibria of (R)- and (S)-Mefenpyr-diethyl in ethanol/water mixtures. J. Chem. Eng. Data 62 (2017), pp. 4411–4418

Li, T., Lorenz, H., Seidel-Morgenstern, A.: Solubility study and thermal stability analysis of calcium propionate. Chem. Eng. Technol. 40 (2017), pp. 1221–1230

Geyyer, R., Dürr, R., Temmel, E., Li, T., Lorenz, H., Palis, S., Seidel-Morgenstern, A., Kienle, A.: Control of continuous mixed-solution mixed-product removal crystallization processes. Chem. Eng. Technol. 40 (2017), pp. 1362–1369

Buchholz, H., Seidel-Morgenstern, A., Lorenz, H.: A contribution to the solution thermodynamics of chiral lactide. Chem. Eng. Technol. 40 (2017), pp. 1268–1275

Buchholz, H., Hylton, R. K., Brandenburg, J. G., Seidel-Morgenstern, A., Lorenz, H., Stein, M., Price, S. L.: Thermochemistry of racemic and enantiopure organic crystals for predicting enantiomer separation. Cryst. Growth Des. 17 (2017), pp. 4676–4686

Horosanskaia, E., Nguyen, T. M., Dinh, V. T., Seidel-Morgenstern, A., Lorenz, H.: Crystallization-based isolation of pure rutin from herbal extract of Sophora Japonica L..     Org. Process Res. Dev. 21 (2017), pp. 1769–1778

Leschinsky, M., Unkelbach, G., Schulze, P., Lorenz, H., Seidel-Morgenstern, A.: Method for precipitating lignin from organosolv pulping liquors. Patent US 2017/0247835 A1 (31.08.2017); WO 2016/062676 A1 (28.04.2016)

2016

Malwade, C. R., Buchholz, H., Rong, B.-G., Qu, H., Christensen, L. P., Lorenz, H., Seidel-Morgenstern, A.: Crystallization of artemisinin from chromatography fractions of Artemisia annua extract. Org. Process Res. Dev. 20 (2016), pp. 646–652

Binev, D., Seidel-Morgenstern, A., Lorenz, H.: Continuous separation of isomers in fluidized bed crystallizers. Cryst. Growth Des. 16 (2016), pp. 1409–1419

Buchholz, H., Emelyanenko, V.N., Lorenz, H., Verevkin, S.P.: An examination of the phase transition thermodynamics of (S)- and (RS)-naproxen as a basis for the design of enantioselective crystallization processes. J. Pharm. Sci. 105 (2016), pp. 1676–1683

Isakov, A. I., Kotelnikova, E. N., Münzberg, S., Bocharov, S. N., Lorenz, H.: Solid phases in the system L-valine – L-isoleucine. Cryst. Growth Des. 16 (2016), pp. 2653–2661

Münzberg, S., Lorenz, H., Seidel-Morgenstern, A.: Multistage counter-current crystallization for the separation of solid solutions. Chem. Eng. Technol. 39 (2016), pp. 1242–1250

Kort, A.-K., Lorenz, H., Seidel-Morgenstern, A.: Physico-chemical properties of the chiral fungicide fenamidone and strategies for enantioselective crystallization. Chirality 28 (2016), pp. 514–520

Lorenz, H., Buchholz, H. (Eds.): BIWIC 2016: 23rd International Workshop on Industrial Crystallization. Cuvillier Verlag, Göttingen, 2016 (ISBN 978-3-7369-9322-8)

Tulashie, S. K., Polenske, D., Seidel-Morgenstern, A., Lorenz, H.: Solid phase and oscillating solution crystallization behavior of (+)- and (-)-N-methylephedrine. J. Pharm. Sci. 105 (2016), pp. 3359–3365

Temmel, E., Eisenschmidt, H., Lorenz, H., Sundmacher, K., Seidel-Morgenstern, A.: A short-cut method for the quantification of crystallization kinetics. 1. Method development. Cryst. Growth Des. 16 (2016), pp. 6743–6755

Temmel, E., Eicke, M., Lorenz, H., Seidel-Morgenstern, A.: A short-cut method for the quantification of crystallization kinetics. 2. Experimental application. Cryst. Growth Des. 16 (2016), pp. 6756–6768.

Horosanskaia, E., Lorenz, H., Seidel-Morgenstern, A., Minh Tan, N., Dinh Tien, V.: Batch and semi-continuous isolation of highly pure Rutin from rutin extract of plant Sophora Japonica. Patent VN 1-2016-01852 (20.05.2016)

2015

Taratin, N., Lorenz, H., Binev, D., Seidel-Morgenstern, A., Kotelnikova, E.: Solubility equilibria and crystallographic characterization of the L-threonine/L-allo-threonine system. Part 2: Crystallographic characterization of solid solutions in the threonine diastereomeric system. Cryst. Growth Des. 15 (2015), pp. 137–144

von Langermann, J., Temmel, E., Seidel-Morgenstern, A., Lorenz, H.: Solid phase behavior in the chiral systems of various 2-hydroxy-2-phenylacetic acid (mandelic acid) derivatives. J. Chem. Eng. Data 60 (2015), pp. 721–728

Binev, D., Seidel-Morgenstern, A., Lorenz, H.: Study of crystal size distributions in a fluidized bed crystallizer. Chem. Eng. Sci. 133 (2015), pp. 116–124

Galan, K., Eicke, M.J., Elsner, M.P., Lorenz, H., Seidel-Morgenstern, A.: Continuous preferential crystallization of chiral molecules in single and coupled Mixed-Suspension Mixed-Product-Removal crystallizers. Cryst. Growth Des. 15 (2015), pp. 1808–1818

Isakov, A., Kotelnikova, E., Lorenz, H.: Non-equimolar discrete phases formed in the system of malic acid enantiomers. Chem. Eng. Technol. 38 (2015), pp. 1047–1052

Horváth, Z., Horosanskaia, E., Lee, J.W., Lorenz, H., Gilmore, K., Seeberger, P.H., Seidel-Morgenstern, A.: Recovery of artemisinin from a complex reaction mixture using continuous chromatography and crystallization. Org. Process Res. Dev. 19 (2015), pp. 624–634

Hylton, R.K., Tizzard, G.J., Threlfall, T.L., Ellis, A.L., Coles, S.J., Seaton, C.C., Schulze, E., Lorenz, H., Seidel-Morgenstern, A., Stein, M., Price, S.L.: Are the crystal structures of enantiopure and racemic mandelic acids determined by kinetics or thermodynamics? J. Am. Chem. Soc. 137 (2015), pp. 11095–11104

Schulze, P., Seidel-Morgenstern, A., Lorenz, H., Leschinsky, M., Unkelbach, G.: Advanced process for precipitation of lignin from ethanol organosolv spent liquors. Bioresour. Technol. 199 (2015), pp. 128–134

2014

Binev, D., Taratin, N., Kotelnikova, E., Seidel-Morgenstern, A., Lorenz, H.: Solubility equilibria and crystallographic characterization of the L-threonine/L-allo-threonine system. Part 1: Solubility equilibria in the threonine diastereomeric system. Cryst. Growth Des. 14 (2014), pp. 367–373

Lorenz, H., Seidel-Morgenstern, A.: Processes to separate enantiomers. Angew. Chem. Int. Ed. 53 (2014), pp. 1218–1250

Lorenz, H., Seidel-Morgenstern, A.: Verfahren zur Enantiomerentennung. Angew. Chem. 126 (2014), pp. 1240–1274

Horosanskaia, E., Seidel-Morgenstern, A., Lorenz, H.: Investigation of drug polymorphism: Case of artemisinin. Thermochim. Acta 578 (2014), pp. 74–81

Borchert, C., Temmel, E., Eisenschmidt, H., Lorenz, H., Seidel-Morgenstern, A., Sundmacher, K.: Image-based in-situ identification of face specific crystal growth rates from crystal populations. Cryst. Growth Des. 14 (2014), pp. 952–971

Sistla, V. S., von Langermann, J., Lorenz, H., Seidel-Morgenstern, A.: Occurrence and consequences of differences in the cation/anion-ratios during classical resolution: D-/L-serine benzyl ester 2,3-toluyl-D-tartrate. Cryst. Res. Technol. 49 (2014), pp. 514–520

Fayzullin, R. R., Lorenz, H., Bredikhina, Z. A., Bredikhin, A. A., Seidel-Morgenstern, A.: Solubility and some crystallization properties of conglomerate forming chiral drug guaifenisin in water. J. Pharm. Sci. 103 (2014), pp. 3176–3182

Lorenz, H., Polenske, D., Klukas, L., Seidel-Morgenstern, A.: Method for separation of racemic compound-forming chiral substances by a cyclic crystallization process and a crystallization device. Patent US 8,822,721 B2 (02.09.2014); WO 2011/026830 A1 (10.03.2011); EP 2 292 306 A1 (09.03.2011)

2013

Lorenz, H.: Solubility and Solution Equilibria in Crystallization. In: Beckmann, W. (Ed.): Crystallization: Basic Concepts and Industrial Applications, Wiley-VCH, Weinheim 2013, pp. 35–74

Lorenz, H. and Beckmann, W.: Purification by Crystallization. In: Beckmann, W. (Ed.): Crystallization: Basic Concepts and Industrial Applications, Wiley-VCH, Weinheim 2013, pp. 129–148

Kaemmerer, H., Seidel-Morgenstern, A., Lorenz, H.: Chiral separation of systems of high eutectic composition by a combined process: Case study of serine enantiomers. Chem. Eng. Process.: Process Intensification 67 (2013), pp. 71–79

Robl, S., Gou, L., Gere, A., Sordo, M., Lorenz, H., Mayer, A., Pauls, C., Leonhard, K., Bardow, A., Seidel-Morgenstern, A., Schaber, K.: Chiral separation by combining pertraction and preferential crystallization. Chem. Eng. Process.: Process Intensification 67 (2013), pp. 80–88

Sistla, V. S., Lorenz, H., Seidel-Morgenstern, A.: Crystallization-based resolution process for the 2,3-dibenzoyl-D/L-tartrate salts of D-/L-serine benzyl ester. Cryst. Growth Des. 13 (2013), pp. 2548–2556

Temmel, E., Wloch, S., Müller, U., Grawe, D., Eilers, R., Lorenz, H., Seidel-Morgenstern, A.: Aufreinigung durch mehrstufige Gegenstromkristallisation zur Herstellung hochreiner Pharmazeutika. Chem. Ing. Tech. 85 (2013), S. 1581–1588

Temmel, E., Wloch, S., Müller, U., Grawe, D., Eilers, R., Lorenz, H., Seidel-Morgenstern, A.: Separation of systems forming solid solutions using counter-current crystallization. Chem. Eng. Sci. 104 (2013), pp. 662–673

Lorenz, H., Le Minh, T., Kaemmerer, H., Buchholz, H., Seidel-Morgenstern, A.: Exploitation of shifts of eutectic compositions in crystallization-based enantioseparation. Chem. Eng. Res. Des. 91 (2013), pp. 1890–1902

Balawejder, M., Mossety-Leszczak, B., Poplewska, I., Lorenz, H., Seidel-Morgenstern, A., Piatkowski, W., Antos, D.: Modeling and predictions of solid–liquid equilibria for citalopram oxalate as a representative of a solid solution forming system. Fluid Phase Equilibr. 346 (2013), pp. 8–19

Seidel-Morgenstern, A., Lorenz, H., Polenske, D.: Method for separating compound-forming chiral systems. Patent EP 1 924 540 B1 (03.07.2013); US 7,820,860 B2 (26.10.2010); WO 2007/023129 A3 (01.03.2007); DE 10 2005 039 501 A1 (20.08.2005)



Organizational Unit (Department, Group, Facility):

  • Max Planck Institute for Dynamics of Complex Technical Systems
  • Physical and Chemical Foundations of Process Engineering
 
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