MPI Colloquia Series: Prof. Dr. Peter H. Seeberger, Preventing and Curing Infectious Diseases: Carbohydrate Vaccines and Drug Production by Continuous Chemistry

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MPI Colloquia Series: Prof. Dr. Peter H. Seeberger, Preventing and Fighting Infectious Diseases: Carbohydrate Vaccines and Flow Chemistry

  • Date: Oct 12, 2017
  • Time: 04:00 - 05:00
  • Speaker: Prof. Dr. Peter H. Seeberger
  • Director at the Max Planck Institute for Colloids and Interfaces, Potsdam-Golm
  • Location: Max Planck Institute Magdeburg
  • Room: Big Seminar Room "Prigogine"

The Max Planck Institute Magdeburg invites you to its series of colloquia.

Top-class scientists, invited by the Max Planck Institute Magdeburg, give a survey of their research work. Everybody who is interested, is invited to attend.


Abstract

Most pathogens including bacteria, fungi, viruses and protozoa carry unique glycans on their surface. Currently, several vaccines against bacteria are marketed very successfully. Since many pathogens cannot be cultured and the isolation of pure oligosaccharides is extremely difficult, synthetic oligosaccharide antigens provide now a viable alternative. The automated synthesis platform,1, 2 has been commercialized.3,4 The quality control of synthetic oligosaccharides by ion mobility mass spectrometry (IM-MS) is fast and extremely sensitive.5 Currently, the laboratory is pursuing the development of several semi- and fully synthetic carbohydrate vaccines against severe bacterial infections, including multi-resistant hospital acquired infections.5,6 In addition to their function as antigens, synthetic oligosaccharides serve as tools to create monoclonal antibodies, and to establish glycan microarrays to map vaccine epitopes.7 Diagnostic and preventive approaches against a host of bacteria, fungi, and parasites are being pursued.

In recent years continuous flow systems have become increasingly interesting to practitioners of synthetic chemistry. Described is the use of continuous flow systems to produce drug substances and other chemicals via multi step reactions including continuous purification.8 The anti-malaria drug artemisinin and its derivatives as well as other life-saving drugs are used as examples. 8-10


1. Plante, O.J.; Palmacci, E.R.; Seeberger, P.H.; Science 2001, 291, 1523.

2. Seeberger, P.H.; Acc. Chem. Res. 2015, 48, 1450.

3. Hahm, H.S.; Schlegel, M.K.; Hurevich, M.; ….. Seeberger, P.H.; Proc Nat Acad Sci USA, 2017, online; www.glycouniverse.de

4. Hofmann, J.; Hahm, H.S.; Seeberger, P.H.; Pagel, K.; Nature 2015, 526, 241.

5. Parameswarappa, S.G.; Reppe, K.; Geissner, A.; Seeberger, P.H.; Cell Chem. Bio. 2016, 23, 1407.

6. Schumann, B.; Hahm, H.S.; …. Seeberger, P.H.; Science Transl. Med. 2017, 9, eaaf5347.

7. Kamena, F.; Tamborrini, M.; Liu, X.; Kwon, Y.-U.; Thompson, F.; Pluschke, G.; Seeberger; P.H.; Nature Chem. Bio., 2008, 4, 238.

8. Ghislieri, D.; Gilmore, K.; Seeberger, P.H.; Angew. Chem. Int. Ed. 2015, 54, 678-682.

9. Levesque, F.; Seeberger, P.H. Angew. Chem. Int. Ed. 2012, 51, 1706; Kopetzki, D.; Lévesque, F.; Seeberger, P.H.; Chem Eur. J. 2013, 19, 5450; Gilmore, K.; Seeberger, P.H.; Chem. Comm. 2014, 50, 12652.

10. Correia, C.A.; Gilmore, K.; McQuade, D.T.; Seeberger, P.H.; Angew. Chem. Int. Ed. 2015, 54, 4945.


 
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