MPI Kolloquiumsreihe: Prof. Dr. Philip Tinnefeld, DNA in new roles: Tools for Superresolution and Nanobiotechnology
MPI Kolloquiumsreihe: Prof. Dr. Philip Tinnefeld, DNA in new roles: Tools for Superresolution and Nanobiotechnology
- Datum: 27.04.2017
- Uhrzeit: 16:00 - 17:00
- Vortragende(r): Prof. Dr. Philip Tinnefeld
- Institute of Physical and Theoretical Chemistry, TU Braunschweig, NanoBioSciences and Braunschweig Integrated Center of Systems Biology (BRICS) and Laboratory for Emerging Nanometrology (LENA)
- Ort: Max-Planck-Institut Magdeburg
- Raum: Großer Seminarraum "Prigogine"
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DNA in new roles: Tools for Superresolution and Nanobiotechnology
In recent years, DNA nanotechnology has matured to enable robust
production of complex nanostructures and hybrid materials. We have
combined DNA nanotechnology with sensitive optical detection to create
functional single-molecule devices such as nanoscopic rulers for
superresolution microscopy and energy transfer switches. DNA origamis
are also used for single-molecule placement in zeromode waveguides using
nanoadapters and for fluorescence enhancement with gold nanoparticles. I
will discuss DNA origami applications to improve single-molecule
detection and how DNA origami in combination with the recently developed
superresolution technique DNA PAINT can be used to study the
interactions of emitters with metallic nanostructures in a
single-molecule mirage. Finally, I present a new force spectroscopy that
does not require a physical connection to the macroscopic world.
Piconewton forces are applied to DNA structures by DNA nanostructures
and the influence on the binding of proteins is visualized using
Fluorescence Resonance Energy Transfer.