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Marian Weiss, Johannes Patrick Frohnmayer, Lucia Theresa Benk, Barbara Haller, Jan-Willi Janiesch, Thomas Heitkamp, Michael Börsch, Rafael B. Lira, Rumiana Dimova, Reinhard Lipowsky, Eberhard Bodenschatz, Jean-Christophe Baret, Tanja Vidakovic-Koch, Kai Sundmacher, Ilia Platzman, Joachim P. Spatz

Axel von Kamp und Steffen Klamt
Growth-coupled overproduction is feasible for almost all metabolites in five major production organisms
Nature Communications 8, 15926, 22. Juni 2017.
DOI: 10.1038/ncomms15956

Antonio Sorrentino, Tanja Vidakovic-Koch, Richard Hanke-Rauschenbach, Kai Sundmacher
Concentration-alternating frequency response: A new method for studying polymer electrolyte membrane fuel cell dynamics
Electrochimica Acta, Volume 243, 20. Juli 2017, pp. 53-64.
DOI: 10.1016/j.electacta.2017.04.150

Non-equimolar discrete compounds in binary chiral systems of organic substances
CrystEngComm, 2017,19, 1851-1869.
DOI: 10.1039/C6CE02209J
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Peter Benner , Albert Cohen, Mario Ohlberger, und Karen Willcox (Eds.)
Model Reduction and Approximation: Theory and Algorithms
SIAM Publications, Philadelphia, PA, 2017.

Peter Benner
System Reduction for Nanoscale IC Design
Springer International Publishing AG. 2017.
DOI: 10.1007/978-3-319-07236-4

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Design of RNA-based regulators and their implementation into large synthetic gene circuits

Ligand-responsive gene switches are cellular sensors that process specific signals into adjusted gene product responses and transform mammalian cells into useful cell-based machines for next-generation biotechnological and biomedical applications. In this talk, I will present how mammalian cells engineered with such gene switches can readily applied for biotechnological and diagnostic purposes. The construction of larger synthetic gene circuits, however, requires an additional gene control layer to connect multiple switches. RNA-based gene switches are perfectly suited for this function because they act on translation rather than transcription. In this talk, I will present how to build such RNA-based gene switches and implement them into large gene circuits with network topologies reminiscent to electronics that provide engineered cells the ability to perform complex information-processing tasks. [mehr]

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