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Susann Triemer, Kerry Gilmore, Giang T. Vu, Peter H. Seeberger, Andreas Seidel-Morgenstern
Angewandte Chemie International Edition, 21. Februar 2018
DOI: 10.1002/anie.201801424

Björn-Johannes Harder, Katja Bettenbrock, Steffen Klamt
Temperature-dependent dynamic control of the TCA cycle increases volumetric productivity of itaconic acid production by Escherichia coli.
Biotechnology and Bioengineering, Volume 115, Ausgabe 1, Seiten 156–164, Januar 2018, DOI: 10.1002/bit.26446
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Lihong Feng, Athanasios C. Antoulas und Peter Benner
Some a posteriori error bounds for reduced-order modelling of (non-)parametrized linear systems
ESAIM: Mathematical Modelling and Numerical Analysis, Volume 51, Number 6, 27. November 2017
DOI: 10.1051/m2an/2017014

Lado Otrin, Nika Marušič, Claudia Bednarz, Tanja Vidaković-Koch, Ingo Lieberwirth, Katharina Landfester und Kai Sundmacher
Toward Artificial Mitochondrion: Mimicking Oxidative Phosphorylation in Polymer and Hybrid Membranes
Nano Letters, 17 (11), pp 6816–6821, 25. Oktober 2017
DOI: 10.1021/acs.nanolett.7b03093

Eileen Edler und Matthias Stein
Recognition and stabilization of geranylgeranylated human Rab5 by the GDP Dissociation Inhibitor (GDI)
SmallGTPases, pp. 1-16, 25. Oktober 2017
DOI: 10.1080/21541248.2017.1371268
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Marian Weiss, Johannes Patrick Frohnmayer, Lucia Theresa Benk, Barbara Haller, Jan-Willi Janiesch, Thomas Heitkamp, Michael Börsch, Rafael B. Lira, Rumiana Dimova, Reinhard Lipowsky, Eberhard Bodenschatz, Jean-Christophe Baret, Tanja Vidakovic-Koch, Kai Sundmacher, Ilia Platzman, Joachim P. Spatz
Sequential bottom-up assembly of mechanically stabilized synthetic cells by microfluidics
Nature Materials, 16. Oktober 2017
DOI: 10.1038/nmat5005

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514 1429059225

Design of RNA-based regulators and their implementation into large synthetic gene circuits

Ligand-responsive gene switches are cellular sensors that process specific signals into adjusted gene product responses and transform mammalian cells into useful cell-based machines for next-generation biotechnological and biomedical applications. In this talk, I will present how mammalian cells engineered with such gene switches can readily applied for biotechnological and diagnostic purposes. The construction of larger synthetic gene circuits, however, requires an additional gene control layer to connect multiple switches. RNA-based gene switches are perfectly suited for this function because they act on translation rather than transcription. In this talk, I will present how to build such RNA-based gene switches and implement them into large gene circuits with network topologies reminiscent to electronics that provide engineered cells the ability to perform complex information-processing tasks. [mehr]

 
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