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Susann Triemer, Kerry Gilmore, Giang T. Vu, Peter H. Seeberger, Andreas Seidel-Morgenstern
Angewandte Chemie International Edition, 21. Februar 2018
DOI: 10.1002/anie.201801424

Björn-Johannes Harder, Katja Bettenbrock, Steffen Klamt
Temperature-dependent dynamic control of the TCA cycle increases volumetric productivity of itaconic acid production by Escherichia coli.
Biotechnology and Bioengineering, Volume 115, Ausgabe 1, Seiten 156–164, Januar 2018, DOI: 10.1002/bit.26446
Open Access Artikel

Lihong Feng, Athanasios C. Antoulas und Peter Benner
Some a posteriori error bounds for reduced-order modelling of (non-)parametrized linear systems
ESAIM: Mathematical Modelling and Numerical Analysis, Volume 51, Number 6, 27. November 2017
DOI: 10.1051/m2an/2017014

Lado Otrin, Nika Marušič, Claudia Bednarz, Tanja Vidaković-Koch, Ingo Lieberwirth, Katharina Landfester und Kai Sundmacher
Toward Artificial Mitochondrion: Mimicking Oxidative Phosphorylation in Polymer and Hybrid Membranes
Nano Letters, 17 (11), pp 6816–6821, 25. Oktober 2017
DOI: 10.1021/acs.nanolett.7b03093

Eileen Edler und Matthias Stein
Recognition and stabilization of geranylgeranylated human Rab5 by the GDP Dissociation Inhibitor (GDI)
SmallGTPases, pp. 1-16, 25. Oktober 2017
DOI: 10.1080/21541248.2017.1371268
Open Access Artikel

Marian Weiss, Johannes Patrick Frohnmayer, Lucia Theresa Benk, Barbara Haller, Jan-Willi Janiesch, Thomas Heitkamp, Michael Börsch, Rafael B. Lira, Rumiana Dimova, Reinhard Lipowsky, Eberhard Bodenschatz, Jean-Christophe Baret, Tanja Vidakovic-Koch, Kai Sundmacher, Ilia Platzman, Joachim P. Spatz
Sequential bottom-up assembly of mechanically stabilized synthetic cells by microfluidics
Nature Materials, 16. Oktober 2017
DOI: 10.1038/nmat5005

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CELLULAR and MOLECULAR BIOTECHNOLOGY

Synthetic Biology is heralded as a novel approach to the engineering of biosystems that will set the scene for a flourishing knowledge-based bio-economy. Benefits for the fundamental understanding of biological phenomena are also claimed, as rational construction of a system based on hypothesized design principles can be used to test assumptions. The keywords of synthetic biology are rational design, decoupling of conception and fabrication, standardization and component re-use, modularity and hierarchy, orthogonality and context-insensitivity. However, each keyword raises questions of desirability and feasibility. These questions remain ongoing areas of inquiry for the field and require multi-faceted approaches. Beyond the current hype surrounding it, what is the value of synthetic biology for the progress in understanding of biological systems and for the establishment of new biotechnological production platforms? [mehr]

 
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