Publications BPE group

2008

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Wolff, M. W.; Siewert, C.; Lehmann, S.; Opitz, L.; Hansen, S. P.; Djurup, R.; Faber, R.; Reichl, U.: Capturing of cell culture derived Vaccinia Virus by membrane adsorbers. AICHE Annual Meeting, Philadelphia, USA (2008)

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Wolff, M. W.; Venzke, C.; Hansen, S. P.; Djurup, R.; Faber, R.; Reichl, U.: Affinity chromatography of cell culture derived Vaccinia Virus. Vaccine Technology II, Albufeira, Algarve, Portugal (2008)

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2007

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Dietzsch, C.; Genzel, Y.; Reichl, U.: Vero or MDCK cells for influenza A virus production in microcarrier systems? European BioPerspectives 2007, Cologne, Germany (2007)

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Genzel, Y.; Bock, A.; Schwarzer, J.; Dietzsch, C.; Reichl, U.: Implementation of analytical methods during upstream processing for an influenza A virus production process. Vaccine Production : Analytical Methods, Characterisation, Scale-up and Manufacturing, Cologne, Germany (2007)

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Opitz, L.; Zimmermann, A.; Genzel, Y.; Lübben, H.; Reichl, U.; Wolff, M. W.: Lectin-affinity chromatography: a novel purification method for cell culture based Influenza vaccine production from the current season 2006/07. European BioPerspectives 2007, Cologne, Germany (2007)

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Opitz, L.; Zimmermann, A.; Genzel, Y.; Lübben, H.; Reichl, U.; Wolff, M. W.: Lektin-Affinitätschromatographie - Neuartige Methode zur Aufreinigung humaner Influenza Viren aus Zellkulturen zur Impfstoffproduktion. DECHEMA/GVC Vortrag- und Diskussionstagung "Aufarbeitung biotechnologischer Produkte", Osnabrück, Germany (2007)

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Opitz, L.; Zimmermann, A.; Lehmann, S.; Genzel, Y.; Lübben, H.; Reichl, U.; Wolff, M. W.: Efficient influenza virus capture from cell cultivation broth by a novel affinity chromatography. AIChE Annual meeting 2007, Salt Lake City, USA (2007)

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Opitz, L.; Zimmermann, A.; Lehmann, S.; Genzel, Y.; Lübben, H.; Reichl, U.; Wolff, M. W.: Novel capturing method for currently spread influenza viruses from cell cultures by affinity separation. ISPPP 2007, Orlando, USA (2007)

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Rapp, E.; Schwarzer, J.; Reichl, U.: Characterisation of Glycosylation Patterns Utilizing a DNA-Sequenzer and Mass Spectrometry. 14th European Carbohydrate Symposium, Lübeck, Germany (2007)

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Rapp, E.; Schwarzer, J.; Reichl, U.: Characterisation of Glycosylation Patterns Utilizing a DNA-Sequenzer and a MALDI-TOF Mass Spectrometer. 7th Carbohydrate Bioengineering Meeting (CBM7), Braunschweig, Germany (2007)

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Rapp, E.; Schwarzer, J.; Reichl, U.: Elucidation of the Influenza A Virus Glycosylation Patterns with Respect to Vaccine Production Down to the Lower Zeptomolar Range. 21st International Symposium on MicroScale Bioseparations (MSB), Vancouver, BC, Canada (2007)

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Rapp, E.; Vester, D.; Genzel, Y.; Gade, D.; Reichl, U.: Quantitative proteomic analysis of influenza A virus infected mammalian cells: Elucidation of virus / host cell interactions with respect to the vaccine production process. 27th International Symposium & Exhibit on the Separation of Proteins, Peptides & Polynucleotides (ISPPP 2007), Orlando, USA (2007)

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Reichl, U.: A Systems Perspective of Virus Replication in Mammalian Cell Cultures. Meeting at MPI Golm, Potsdam-Golm, Germany (2007)

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Reichl, U.: Influenza Vaccines: Challenges in Optimization of Virus Yields in Mammalian Cell Culture. Vaccine Congress, Amsterdam, The Netherlands (2007)

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Reichl, U.: Characterization of Cell Growth and Influenza Virus Replication in Microcarrier Culture. Kooperationsgespräch bei ROCHE AG, Penzberg, Germany (2007)

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Reichl, U.: A Systems Perspective of Influenza Virus Replication in Cell Cultures. European Conference on Complex Systems, Dresden, Germany (2007)

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Reichl, U.: Theoretical and Experimental Characterization of Influenza Virus Replication in Cell Cultures. Meeting Helmholtz-Zentrum, Braunschweig, Germany (2007)

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Reichl, U.: Theoretical and Experimental Characterization of Influenza Virus Replication in Cell Cultures. DECHEMA-Arbeitsausschuss Biotechnologie, Frankfurt/M., Germany (2007)

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Reichl, U.: Mathematical Modeling of Mammalian Cell Cultures - Cell Growth and Product Synthesis. MPG-CNRS Treffen, Paris, France (2007)

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Reichl, U.: MDCK cell derived influenza vaccines - aspects of up- and downstream processing. Meeting Merck & Co., Inc., USA (2007)

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Reichl, U.: Mathematical Modeling of Mammalian Cell Cultures: From Cell Populations to Individual Cells. Workshop "Systems biology", Leipzig, Germany (2007)

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Ritter, J. B.; Genzel, Y.; Reichl, U.: Metabolite Analysis in Mammalian Cells: How to generate reliable data sets? 20th ESACT meeting, Dresden, Germany (2007)

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Schmidt, J. K.; Riedele, C.; Regestein, L.; Geisler, L.; Reichl, U.: A Medically Relevant Three-Species Mixed Culture in a Chemostat: Mathematical Modelling and Experiments to Study Interaction Effects. European BioPerspectives 2007, Cologne, Germany (2007)

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Schwarzer, J.; Rapp, E.; Reichl, U.: N-glycan analysis method for cell culture derived influenza virus hemagglutinin. Joint Meeting 2007, Lille, France (2007)

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2006

Talk

Genzel, Y.; Kalbfuss, B.; Ritter, J. B.; Schulze-Horsel, J.; Rapp, E.; Vester, D.; Reichl, U.: Characterization and analytical issues on an influenza A virus production process. Vaccines : Quality control, scale-up and manufacture, Hamburg, Germany (2006)

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Genzel, Y.; Reichl, U.: Production of vaccines based on animal cell technology. Production of Biopharmaceuticals in Animal Cell Cultures, Rio de Janeiro, Brazil (2006)

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Genzel, Y.; Reichl, U.: Limits and benefits of the interpretation of extracellular metabolite data in mammalian cell culture. 1st Max Planck Workshop on "Metabolomics", Magdeburg, Germany (2006)

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Genzel, Y.; Sandig, V.; Jordan, I.: Neue Zellsubstrate und Einfluss von Medien und Prozessführung in der Impfstoffproduktion. 24. DECHEMA-Jahrestagung der Biotechnologen, Wiesbaden, Germany (2006)

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Genzel, Y.; Schulze-Horsel, J.; Reichl, U.: High Cell Density Microcarrier Process in a Wave Bioreactor for the Production of Influenza A Virus. Vaccine Technology, Puerto Vallarta, Mexiko (2006)

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Kalbfuss, B.; Gedicke, K.; Seidel-Morgenstern, A.; Reichl, U.: Maximizing productivity in size-exclusion chromatography of influenza virus: A modelling approach. ESBES 6 : 6th European Symposium on Biochemical Engineering Science, Salzburg, Austria (2006)

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Kalbfuss, B.; Wolff, M. W.; Geisler, L.; Thom, V.; Reichl, U.: Konzentrierung und Aufreinigung von Influenza Viren mittels Ionenaustauscher-Membranen. 24. DECHEMA-Jahrestagung der Biotechnologen, Wiesbaden, Germany (2006)

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Kalbfuss, B.; Wolff, M. W.; Genzel, Y.; Zimmermann, A.; Best, C.; Morenweiser, R.; Reichl, U.: A generic purification scheme for the production of human influenza vaccines derived from serum-free mammalian cell culture. Vaccine Technology, Puerto Vallarta, Mexico (2006)

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Kalbfuss, B.; Wolff, M. W.; Genzel, Y.; Zimmermann, A.; Morenweiser, R.; Reichl, U.: Chromatography-based purification of influenza A virus for the production of human whole-virion vaccines. ISPPP 2006 : 26th International Symposium on the Separation of Proteins, Peptides and Polynucleotides, Innsbruck, Austria (2006)

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Reichl, U.: MDCK Cell Derived Influenza Vaccines: Aspects of Up- and Downstream Processing. Meeting Academy of Science, Sofia, Bulgarien (2006)

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Reichl, U.: Dynamics of Influenza Virus Replication in Mammalian Cell Culture. CCEX Workshop, Vancouver, Canada (2006)

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Reichl, U.: MDCK Cell derived Influenza Vaccines: Aspects of Modeling and Experimental Design in Upstream Processing. Meeting at Sanof Pasteur, Toronto, Canada (2006)

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Reichl, U.: Biological Fundamentals, Models and Technologies for Vaccine Production. Perspectives of Research - Identification and Implementation of Research Topics by Organizations : Ringberg-Symposium Mai 2006, Kreuth, Germany (2006)

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Reichl, U.: Mathematical Models for Mammalian Cell Growth and Virus Replication for an Influenza Vaccine Production Process. Technische Universität Berlin : Meeting, Berlin, Germany (2006)

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Ritter, J. B.; Genzel, Y.; Reichl, U.: Monitoring Energy Metabolism: The Challenge of Intracellular Metabolite Analysis of Mammalian Cells in Culture. 1st Max Planck Workshop on "Metabolomics", Magdeburg, Germany (2006)

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Schulze-Horsel, J.; Bock, A.; Genzel, Y.; Reichl, U.: Mammalian cell culture for influenza vaccine production: physiology during cell growth and virus propagation phase. GVC/DECHEMA-Jahrestagungen 2006 mit 24. DECHEMA-Jahrestagung der Biotechnologen, Wiesbaden, Germany (2006)

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Wahl, A.; Nöh, K.; Wiechert, W.: Metabolic and Isotopic Instationary Experiments: A Simulative Study. Metabolic Engineering VI, Noordwijkerhout, The Netherlands (2006)

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Wahl, S. A.; Nöh, K.; Wiechert, W.: Experiments at Metabolic and Isotopic Instationary State: An Exploratory study. Metabolic Engineering VI : From recDNA Towards Engineering Biological Systems, Noordwijkerhout, Netherlands (2006)

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Wolff, M. W.; Kalbfuss, B.; Lehmann, S.; Morenweiser, R.; Opitz, L.; Zimmermann, A.; Reichl, U.: Downstream Processes and Glycan Characterization of MDCK-Cell Derived Influenza Virus. BioProcess Technology - Asia, Singapore (2006)

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Wolff, M. W.; Kalbfuss, B.; Opitz, L.; Zimmermann, A.; Lehmann, S.; Reichl, U.: Downstream Process of Influenza Viruses. European BioPharm Scale-Up Congress 2006, Geneva, Switzerland (2006)

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2005

Talk

Genzel, Y.; Schulze-Horsel, J.; Möhler, L.; Sidorenko, Y.; Reichl, U.: Influenza Vaccines: Challenges in Mammalian Cell Culture Technology. 19th ESACT Meeting, Harrogate, UK (2005)

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Heßeler, J.; Schmidt, J. K.; Reichl, U.; Flockerzi, D.: How to achieve coexistence in the chemostat: a combined mathematical and experimental approach. European Conference on Mathematical and Theoretical Biology (ECMTB), Dresden, Germany (2005)

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Wolff, M.; Kalbfuss, B.; Morenweiser, R.; Zimmermann, A.; Reichl, U.: Chromatography-based Purification of Influenza A Virus for the Production of Human Whole-Virion Vaccines. Viral Vectors and Vaccines Conference, Austin, Texas (2005)

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Wolff, M. W.; Salaklang, J.; Opitz, L.; Schwarzer, J.; Rapp, E.; Kalbfuss, B.; Reichl, U.: Development of a lectin-affinity chromatography step for the downstream processing of influenza virus vaccines. AICHE Annual Meeting 2005, Cincinnati, Ohio, USA (2005)

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Full

2004

Talk

Genzel, Y.; König, S.; Reichl, U.: Amino acid analysis in mammalian cell culture based virus vaccine production processes. IICS : 17th annual International Ion Chromatography Symposium, Trier, Germany (2004)

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Rapp, E.; Lubda, D.; Seidel-Morgenstern, A.; Reichl, U.; Tallarek, U.: Sheathless ESI-Interface for Coupling Capillary Separation Techniques to Mass Spectromety. 37. Diskussionstagung der Deutschen Gesellschaft für Massenspektrometrie, Leipzig, Germany (2004)

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Talk (347)