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01, February 2010 a new Department of Systems Biology at the Faculty of Natural Sciences
at the OvG University of Magdeburg has been established with support from the BMBF. Fully
equipped molecular biology laboratories for biochemical, molecular and cell biological work
for quantitative analyses of cellular signal transduction have been installed. Since December
2010, the group is able to perform the first experiments. Aim of the related work package is to elucidate the
importance of the adapter protein Gab1 in the regulation of the dynamics of the signal
transduction of the cytokine interleukin-6 (IL-6). Gab1 coordinates IL-6-dependently the
activation of the MAPK cascade and the PI3K cascade. They have shown that activation of these
signaling pathways is essential for membrane recruitment of Gab1. Additional signalling
molecules of both signaling pathways associate to Gab1. Theoretical considerations show
potential negative and positive feedback motifs as well as coherent and incoherent
feed-forward motifs that could affect the dynamics of the signal significantly.
The group is now trying to verify these network motifs experimentally and in parallel
they check with their cooperation partners from the group of Dr. Klamt the potential
importance of these network motifs for the dynamics of MAPK- and PI3K-activation
in silico.
Contact
Otto-von-Guericke Universität Magdeburg
Fakultät für Naturwissenschaften
Institut für Biologie
Lehrstuhl für Systembiologie
Leipziger Straße 44 / Haus 65/ ZENIT I
39120 Magdeburg
Tel: +49 (0) 391 6117-150/155
Fax: +49 (0) 391 6117-154
E-mail: fred.schaper@ovgu.de
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