Master Thesis/Internship “Advanced development of sugar nucleotide regeneration and in-vitro glycosylation cascades”

Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg

Structural and Cell Biology Chemistry Complex Systems

Type of Job

Young Researchers

Master Thesis/Internship “Advanced development of sugar nucleotide regeneration and in-vitro glycosylation cascades”

Job offer from March 19, 2018

Master Thesis / Internship in Biotechnology / Chemical Engineering / Bioengineering - 2 positions available - “Advanced development of sugar nucleotide regeneration and in-vitro glycosylation cascades”

Background

Glycosylation is an important modification of proteins, and is involved in the regulation of biological activity and stability of many proteins. At the Max-Planck-Institute for Dynamics of Complex Technical Systems (MPI) in Magdeburg, an in-vitro enzyme cascade is build up to produce lipid-linked oligosaccharides - precursors for in-vitro glycoengineering. The cascade also relies on efficient sugar nucleotide regeneration. We offer two exciting projects in the advanced development of sugar nucleotide regeneration and in vitro glycosylation cascades. The focus of the projects will be as follows:           

  • Recombinant production of enzymes in microbial systems and downstream processing
  • Establishing multienzyme cascades for the efficient synthesis of lipid-linked oligosaccharides

The candidates will have the opportunity to work on key technologies and use state-of-the-art equipment. In-depth supervision and training will be provided by MPI staff.

Requirements

  • Background in Biotechnology, Technical Biology, Bioprocess Engineering, Bioengineering
  • Good experience of lab works and ideally, experience with protein expression and downstream processing
  • Motivation, curiosity and ability to work in a team

Our offer

  • Exciting research projects and the opportunity to develop key technologies
  • First-class supervision and thorough training by our staff
  • Training on state-of-the-art equipment for biotechnological research and development
  • Acquisition of expertise in a key technology of the future

Your application

Applications in German or English are welcome. Please include your CV and transcript of records.

Start: July 2018

Contacts

Dr. Thomas Rexer
E-Mail: Phone: +49 (0) 391 6110 375

Reza Mahour, MSc
E-Mail: Phone: +49 (0) 391 6110 371

 
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