Team Leader (USP)

PD Dr. Yvonne Genzel
PD Dr. Yvonne Genzel
Phone: +49 391 6110 257

Team (USP)

Alexander Nikolay
PhD Student
Daniel Vazquez-Ramirez
PhD Student
Felipe Ignacio Tapia-Delgado
PhD Student
Thomas Bissinger
PhD Student
Claudia Best
Technical Assistant
Ilona Behrendt
Technical Assistant
Susanne König
Technical Assistant
Heike Sperlich
Laboratory coworker

Upstream Processing

Upstream Processing

Many products for the pharmaceutical and food industry are nowadays produced by biotechnological processes, complementing and replacing more and more existing chemical manufacturing processes. Ideas for innovative products and new approaches for their production on a small scale have to be transformed into complete process trains at a large scale. Production costs, working volume, effective scale-up, product yield, downstream processing and many other points have to be optimized before a process will be used in pharmaceutical industry. We focus on the optimization and scale-up of bioprocesses on different levels.  Process parameters, growth conditions, product formation, medium design as well as high cell density cultivations are of interest on the process level. In addition, properties of cell lines, aspects of cellular growth and metabolism, protein expression as well as virus replication are being considered.
Bioprocesses that are currently looked at are mainly virus production processes for influenza virus and modified vaccinia virus Ankara (MVA) and and yellow fever virus with a focus on production of viruses and viral vectors for vaccination and gene therapy. Therefore, growth and product formation of adherent as well as suspension cells are being evaluated.

<i>Vaccinia virus replication cycle. </i> Zoom Image
Vaccinia virus replication cycle.
<em>Influenza virus replication cycle (S. Heldt et al. submitted to PLoS Computational Biology) </em> Zoom Image
Influenza virus replication cycle (S. Heldt et al. submitted to PLoS Computational Biology)
<p><em>Yellow fever virus replication cycle.</em></p>

Yellow fever virus replication cycle.

 
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