Head of the Group

Prof. Dr.-Ing. Udo Reichl
Prof. Dr.-Ing. Udo Reichl
Phone: +49 391 6110 201
Fax: +49 391 6110 203
Room: N0.19

Contact Person

Annegret Frauendienst
Phone:+49 391 6110 200Fax:+49 391 6110 203

Group Page

Publications

Publications BPE group

Journal Article (11)

  1. 1.
    Abeln, M.; Borst, K. M.; Cajic, S.; Thiesler, H.; Kats, E.; Albers, I.; Kuhn, M.; Kaever, V.; Rapp, E.; Münster-Kühnel, A. et al.; Weinhold, B.: Sialylation Is Dispensable for Early Murine Embryonic Development in Vitro. ChemBioChem: A European Journal of Chemical Biology 18 (13), pp. 1305 - 1306 (2017)
  2. 2.
    Heyer, R.; Schallert, K.; Zoun, R.; Becher, B.; Saake, G.; Benndorf, D.: Challenges and perspectives of metaproteomic data analysis. Journal of Biotechnology 261, pp. 24 - 36 (2017)
  3. 3.
    Hämmerling, F.; Pieler, M.; Hennig, R.; Serve, A.; Rapp, E.; Wolff, M. W.; Reichl, U.; Hubbuch, J.: Influence of the production system on the surface properties of influenza A virus particles. Engineering in Life Sciences 17 (10), pp. 1071 - 1077 (2017)
  4. 4.
    Kohrs, F.; Heyer, R.; Bissinger, T.; Kottler, R.; Schallert, K.; Püttker, S.; Behne, A.; Rapp, E.; Benndorf, D.; Reichl, U.: Proteotyping of laboratory-scale biogas plants reveals multiple steady-states in community composition. Anaerobe 46, pp. 56 - 68 (2017)
  5. 5.
    Konze, S. A.; Cajic, S.; Oberbeck, A.; Hennig, R.; Pich, A.; Rapp, E.; Buettner, F. F. R.: Quantitative Assessment of Sialo-Glycoproteins and N-Glycans during Cardiomyogenic Differentiation of Human Induced Pluripotent Stem Cells. ChemBioChem: A European Journal of Chemical Biology 18 (13), pp. 1317 - 1331 (2017)
  6. 6.
    Liu, Y.; McBride, R.; Stoll, M.; Palma, A. S.; Silva, L.; Agravat, S.; Aoki-Kinoshita, K. F.; Campbell, M. P.; Costello, C. E.; Dell, A. et al.; Haslam, S. M.; Karlsson, N. G.; Khoo, K.-H.; Kolarich, D.; Novotny, M. V.; Packer, N. H.; Ranzinger, R.; Rapp, E.; Rudd, P. M.; Struwe, W. B.; Tiemeyer, M.; Wells, L.; York, W. S.; Zaia, J.; Kettner, C.; Paulson, J. C.; Feizi, T.; Smith, D. F.: The minimum information required for a glycomics experiment (MIRAGE) project: improving the standards for reporting glycan microarray-based data. Glycobiology 27 (4), pp. 280 - 284 (2017)
  7. 7.
    Marichal-Gallardo, P.; Pieler, M.; Wolff, M. W.; Reichl, U.: Steric exclusion chromatography for purification of cell culture-derived influenza A virus using regenerated cellulose membranes and polyethylene glycol. Journal of Chromatography A 1483 (3), pp. 110 - 119 (2017)
  8. 8.
    Pieler, M.; Heyse, A.; Wolff, M. W.; Reichl, U.: Specific ion effects on the particle size distributions of cell culture–derived influenza A virus particles within the Hofmeister series. Engineering in Life Sciences 17 (5), pp. 470 - 478 (2017)
  9. 9.
    Pralow, A.; Hoffmann, M.; Nguyen-Khuong, T.; Rapp, E.; Reichl, U.: Improvement of the glycoproteomic toolbox with the discovery of a unique C-terminal cleavage specificity of flavastacin for N-glycosylated asparagine. Scientific Reports 7, 11419 (2017)
  10. 10.
    Ricken, B.; Kolvenbach, B. A.; Bergesch, C.; Benndorf, D.; Kroll, K.; Strnad, H.; Vlcek, C.; Adaixo, R.; Hammes, F.; Shahgaldian, P. et al.; Schäffer, A.; Kohler, H.-P. E.; Corvini , P. F.-X.: FMNH2-dependent monooxygenases initiate catabolism of sulfonamides in Microbacterium sp. strain BR1 subsisting on sulfonamide antibiotics. Scientific Reports 7, 15783 (2017)
  11. 11.
    Tapia, F.; Jordan, I.; Genzel, Y.; Reichl, U.: Efficient and stable production of Modified Vaccinia Ankara virus in two-stage semi-continuous and in continuous stirred tank cultivation systems. PLoS One 12 (8), e0182553 (2017)

Book Chapter (1)

  1. 12.
    Butler, M.; Reichl, U.: Animal Cell Expression Systems. In: Advances in Biochemical Engineering/Biotechnology, pp. 1 - 36. Springer, Cham, Switzerland (2017)

Meeting Abstract (1)

  1. 13.
    Tapia, F.; Genzel, Y.; Reichl, U.; Sandig, V.: Stirred tanks in cascades and plug-flow tubular bioreactors for continuous production of viral vaccines. In: ECI Symposium Series. Integrated Continuous Biomanufacturing III, Cascais, Portugal, September 17, 2017 - September 21, 2017. (2017)

Talk (21)

  1. 14.
    Carvalho, S.B.; Fortuna, A. R.; Alves, P. M.; Wolff, M. W.; Reichl, U.; Corrondo, M.J.T.; Peixoto, C.: Improving purification of influenza virus-like particles using a pseudo-affinity strategy. AFFINITY 2017: 22nd Meeting of the International Society for Molecular Recognition, Paris, France (2017)
  2. 15.
    Fortuna, A. R.; Carvalho, S. B.; Van Teeffelen, S.; Taft, F.; Villain, L.; Peixoto, C.; Carrondo, M. J. T.; Wolff, M. W.; Reichl, U.: Sulfated cellulose membrane adsorbers as a platform technology for purification of cell culture-derived influenza virus particles. ICOM 2017: International Congress on Membranes and Membrane Processes, San Francisco, USA (2017)
  3. 16.
    Genzel, Y.: ESACT Course on Cell Culture-based Viral Vaccines (2nd Edition): Upstream Process Intensification. ESACT Course 2017, Llafranc, Spain (2017)
  4. 17.
    Genzel, Y.: ESACT Course on Cell Culture-based Viral Vaccines (2nd Edition): Upstream Process Intensification. ESACT Course 2017, Llafranc, Spain (2017)
  5. 18.
    Hennig, R.; Cajic, S.; Borowiak, M.; Hoffmann, M.; Kottler, R.; Reichl, U.; Rapp, E.: Longitudinal Studies for Personalized Diagnostics. 12th Jenner Glycobiology and Medicine Symposium "Translational Glycobiology - From Bench to Bedsode", Dubrovnik, Croatia (2017)
  6. 19.
    Hennig, R.; Cajic, S.; Borowiak, M.; Hoffmann, M.; Kottler, R.; Reichl, U.; Rapp, E.: The Glycoanalytical Toolbox. University of Copenhagen Copenhagen Center for Glycomics, Copenhagen, Denmark (2017)
  7. 20.
    Heyer, R.; Kohrs, F.; Benndorf, D.; Schallert, K.; deVrieze, J.; Rapp, E.; Reichl, U.: Proteotyping enables grouping and classification of biogas plant microbiomes. Proteomic Forum 2017, Potsdam, Germany (2017)
  8. 21.
    Heyer, R.; Schallert, K.; Kohrs, F.; Benndorf, D.; Rapp, E.; Reichl, U.: Function of the different microbial groups within the biogas process and their dependence on process parameters. 3rd International Conference on Biogas Microbiology (ICBM-3), Wageningen, The Netherlands (2017)
  9. 22.
    Hoffmann, M.; Bartels, M.F.; Hennig, R.; Pioch, M.; Reichl, U.; Strahl, S.; Rapp, E.: Unravelling the Interplay between Protein O-Mannosylation and N-Glycosylation-An N-Glycomic and N-Glycoproteomic Study of Human N-Cadherin. DFG FOR 2509 Kick-off Meeting, Heidleberg, Germany (2017)
  10. 23.
    Laske, T.; Bachmann, M.; Dostert, M.; Karlas, A.; Wirth, D.; Frensing, T.; Reichl, U.: Model-based characterization of influenza A virus production in genetically engineered cell lines elucidates changes in virus replication. 3rd Workshop on Virus Dynamics, Heidelberg, Germany (2017)
  11. 24.
    Nikolay, A.; Genzel, Y.; Reichl, U.: Process intensification – Yellow fever virus and Zika virus production in suspension cells. 13th PEACe Conference: Conference on Protein Expression in Animal Cells, Valencia, Spain (2017)
  12. 25.
    Pioch, M.; Hoffmann, M.; Pralow, A.; Reichl, U.; Rapp, E.: OpenSource toolbox for semi-automated analysis of glycopeptide mass spectrometry data. 5th Beilstein Glyco-Bioinformatics Symposium, Berlin, Germany (2017)
  13. 26.
    Pioch, M.; Hoffmann, M.; Pralow, A.; Nguyen-Khuong, T.; Reichl, U.; Rapp, E.: glyXtoolMS-Towards Automated Analysis of Glycopeptide Mass Spectrometry Data. 5th Beilstein Glyco-Bioinformatics Symposium, Berlin, Germany (2017)
  14. 27.
    Pralow, A.; Nguyen-Khuong, T.; Pioch, M.; Hennig, R.; Hoffmann, M.; Rapp, E.; Reichl, U.: Structural and site-specific N-glycan analysis of influenza A/PR8/34 virus propagated in adherent and suspension MDCK cells. 28th Joint Glycobiology Meeting 2017, Aachen, Germany (2017)
  15. 28.
    Rapp, E.: Unravelling the Correlation between Different ER-Based Types of Glycosylation via Glyco/Proteo-Analytics. DFG FOR 2509 Kick-off meeting, Heidelberg, Germany (2017)
  16. 29.
    Rexer, T.; Schildbach, A.; Rapp, E.; Reichl, U.; Pietzsch, M.: In-vitro synthesis of phytanyl-pyrophosphate-linked oligosaccharides by cascades of glycosyltransferases as basic platform for N-glycosylation of therapeutic proteins. GlycoBioTec Symposium 2017, Berlin, Germany (2017)
  17. 30.
    Rüdiger, D.; Kupke, S. Y.; Zmora, P.; Reichl, U.: Multiscale model of influenza virus infection predicts viral release dynamics in cell cultures for a wide range of infection conditions. 3rd Workshop on Virus Dynamics, Heidelberg, Germany (2017)
  18. 31.
    Tapia, F.: A continuous tubular bioreactor for stable production of influenza virus vaccines. 25th ESACT Meeting, Lausanne, Switzerland (2017)
  19. 32.
    Tapia, F.: A continuous tubular bioreactor for stable production of influenza virus vaccines. CChIQ2017: National Conference of Chemical Engineering, Santiago, Chile (2017)
  20. 33.
    Tapia, F.: A continuous tubular bioreactor for stable production of influenza virus vaccines. SOMICH Coloquios de Microbiologia, Santiago, Chile (2017)
  21. 34.
    Zmora, P.: Vaccines against emerging infectious diseases (Ebola, SARS, MERS, influenza) - future or present? Tropical & Parasitic Disease Conference, Poznan, Poland (2017)

Poster (19)

  1. 35.
    Behne, A.; Bock, A.; Hennig, R.; Reichl, U.; Rapp, E.: Characterizing the Sweet Sites of Therapeutic Glycoproteins using glyXbox. Congress: „new and emerging technologies“, Potsdm, Germany (2017)
  2. 36.
    Bergmann, C.; Schildbach, A.; Rexer, T.; Rapp, E.; Reichl, U.; Pietzsch, M.: In-vitro synthesis of a phytanyl-pyrophosphate-linked oligosaccharide by a cascade of Alg2 and Alg11 as part of a platform for N-glycosylation of therapeutic proteins. GlycoBioTec Symposium 2017, Berlin, Germany (2017)
  3. 37.
    Bissinger, T.; Rodrigues Correia Ramos, J.; Ringeisen, J.; Genzel, Y.; Reichl, U.: Intracellular Metabolic Pool Dynamics in MDCK Suspension Cells during Growth and Influenza Virus Infection. 25th ESACT Meeting, Lausanne, Switzerland (2017)
  4. 38.
    Fortuna, A. R.; Tamargo Granados, L.; Gasczyk, C.; Grundke, S.; Toeppner, K.; Hundt, B.; Schleuss, T.; Villain, L.; Wolff, M. W.; Reichl, U.: Tangential flow filtration of influenza virus feed streams for veterinary vaccine production. ICOM 2017: International Congress on Membranes and Membrane Processes, San Francisco, USA (2017)
  5. 39.
    Hennig, R.; Bock, A.; Behne, A.; Reichl, U.; Rapp, E.: The glyXtoolTM software suite - introducing the next generation of automated high-throughput glycoprofiling. Congress: „new and emerging technologies“, Potsdm, Germany (2017)
  6. 40.
    Hoffmann, M.; Bartels, M.F.; Hennig, R.; Pioch, M.; Reichl, U.; Strahl, S.; Rapp, E.: Unravelling the Interplay between Protein O-Mannosylation and N-Glycosylation-An N-Glycomic and N-Glycoproteomic Study of Human N-Cadherin. DFG FOR 2509 Kick-off Meeting, Heidleberg, Germany (2017)
  7. 41.
    Hoffmann, M.: Unravelling the Correlation between Different ER-Based Types of Glycosylation via Glyco/Proteo-Analytics. DFG FOR 2509 Kick-off meeting, Heidelberg, Germany (2017)
  8. 42.
    Hoffmann, M.; Pioch, M.; Pralow, A.; Nguyen-Khuong, T.; Hennig, R.; Kottler, R.; Reichl, U.; Rapp, E.: Site-Specific N-and O-Glycoproteomic Analysis Using Stepped Collisional Energy Fragmentation on a Linear Iontrap/ Orbitrap Hybrid Mass Spectrometer. GlycoBioTec Symposium 2017, Berlin, Germany (2017)
  9. 43.
    Koch, S.; Benndorf, D.; Kohrs, F.; Lahmann, P.; Reichl, U.; Klamt, S.: Strategies for Modeling of Large-Scale Metabolic Models of Microbial Communities. Metabolic Pathway Analysis 2017, Bozeman, Montana, USA (2017)
  10. 44.
    Kohrs, F.; Heyer, R.; Bissinger, T.; Kottler, R.; Schallert, K.; Püttker, S.; Behne, A.; Rapp, E.; Benndorf, D.; Reichl, U.: Proteotyping of microbial communities from laboratory-scale biogas plants reveals multiple steady-states. 14th Symposium on Bacterial Genetics and Ecology (BAGECO 14), Aberdeen, Scotland (2017)
  11. 45.
    Mahour, R.; Klapproth, J.; Rexer, T.; Schildbach, A.; Pietzsch, M.; Rapp, E.; Reichl, U.: In vitro multienzymatic network for production of UDP-GlcNAc. DECHEMA Summer School 2017: Biotransformations 2017, Hannover, Germany (2017)
  12. 46.
    Mahour, R.; Klapproth, J.; Rexer, T.; Schildbach, A.; Pietzsch, M.; Rapp, E.; Reichl, U.: In vitro multienzymatic network for production of UDP-GlcNAc. GlycoBioTec Symposium 2017, Berlin, Germany (2017)
  13. 47.
    Nikolay, A.; Castilho, L.; Genzel, Y.; Reichl, U.: Process intensification of yellow fever virus and Zika virus production by perfusion bioreactors. 25th ESACT Meeting, Lausanne, Switzerland (2017)
  14. 48.
    Nikolay, A.; Castilho, L.; Genzel, Y.; Reichl, U.: Production of yellow fever virus and Zika virus in perfusion bioreactors. DECHEMA Himmelfahrtstagung "Models for Developing and Optimising Biotech Production", Neu-Ulm, Germany (2017)
  15. 49.
    Pralow, A.; Nguyen-Khuong, T.; Pioch, M.; Hennig, R.; Hoffmann, M.; Rapp, E.; Reichl, U.: Comprehensive structural and site-specific N-glycan analysis of influenza A/PR8/34 virus propagated in adherent and suspension MDCK cells. GlycoBioTec Symposium 2017, Berlin, Germany (2017)
  16. 50.
    Rexer, T.; Schildbach, A.; Rapp, E.; Reichl, U.; Pietzsch, M.: In-vitro synthesis of phytanyl-pyrophosphate-linked oligosaccharides by cascades of glycosyltransferases as basic platform for N-glycosylation of therapeutic proteins. DECHEMA Summer School 2017: Biotransformations 2017, Hannover, Germany (2017)
 
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