Head of the Group

Prof. Dr.-Ing. Udo Reichl
Prof. Dr.-Ing. Udo Reichl
Phone: +49 391 6110 201
Fax: +49 391 6110 203
Room: N0.19

Contact Person

Annegret Frauendienst
Phone:+49 391 6110 200Fax:+49 391 6110 203

Group Page

Publications

Publications BPE group

Journal Article (16)

  1. 1.
    Antoniukas, L.; Grammel, H.; Sasnauskas, K.; Reichl, U.: Profiling of external metabolites during production of hantavirus nucleocapsid protein with recombinant Saccharomyces cerevisiae. Biotechnology Letters 30 (3), pp. 415 - 420 (2008)
  2. 2.
    Kalbfuss, B.; Knöchlein, A.; Kröber, T.; Reichl, U.: Monitoring Influenza Virus Content in Vaccine Production: Precise Assays for the Quantitation of Hemagglutination and Neuraminidase Activity. Biologicals 36 (3), pp. 145 - 161 (2008)
  3. 3.
    Kalbfuss, B.; Flockerzi, D.; Seidel-Morgenstern, A.; Reichl, U.: Size-exclusion chromatography as a linear transfer system: Purification of human influenza virus as an example. Journal of Chromatography B 873 (1), pp. 102 - 112 (2008)
  4. 4.
    Möhler, L.; Bock, A.; Reichl, U.: Segregated Mathematical Model for Growth of Anchorage-Dependent MDCK Cells in Microcarrier Culture. Biotechnology Progress 24 (1), pp. 110 - 119 (2008)
  5. 5.
    Opitz, L.; Zimmermann, A.; Lehmann, S.; Genzel, Y.; Lübben, H.; Reichl, U.; Wolff, M. W.: Capture of cell culture-derived influenza virus by lectins: strain independent, but host cell dependent. Journal of Virological Methods 154 (1-2), pp. 61 - 68 (2008)
  6. 6.
    Pohlscheidt, M.; Kauling, D. J.; Havekost, D.; Bödeker, B.; Langer, U.; Apeler, H.; Hörlein, H. D.; Rübsamen-Waigmann, H.; Reichl, U.; Henzler, H. J.: Auslegungsunterlagen für Bioreaktoren zur Maßstabsvergrößerung eines microcarrierbasierenden Virusproduktionsprozesses. Chemie-Ingenieur-Technik 80 (6), pp. 821 - 830 (2008)
  7. 7.
    Ritter, J. B.; Genzel, Y.; Reichl, U.: Simultaneous extraction of several metabolites of energy metabolism and related substances in mammalian cells: Optimization using experimental design. Analytical Biochemistry 373, pp. 349 - 369 (2008)
  8. 8.
    Schulze-Horsel, J.; Genzel, Y.; Reichl, U.: Flow cytometric monitoring of influenza A virus infection in MDCK cells during vaccine production. BMC Biotechnology 8, p. 45 (2008)
  9. 9.
    Schwarzer, J.; Rapp, E.; Reichl, U.: N-Glycan Analysis by CGE-LIF – Profiling Influenza A Virus Hemagglutinin N-Glycosylation during Vaccine Production. Electrophoresis 29 (20), pp. 4203 - 4214 (2008)
  10. 10.
    Sidorenko, Y.; Schulze-Horsel, J.; Voigt, A.; Reichl, U.; Kienle, A.: Stochastic Population Balance Modeling of Influenza Virus Replication in Vaccine Production Processes. Chemical Engineering Science 63, pp. 157 - 169 (2008)
  11. 11.
    Sidorenko, Y.; Wahl, A.; Dauner, M.; Genzel, Y.; Reichl, U.: Comparison of Metabolic Flux Distributions for MDCK Cell Growth in Glutamine- and Pyruvate-Containing Media. Biotechnology Progress 24 (2), pp. 311 - 320 (2008)
  12. 12.
    Sidorenko, Y.; Antoniukas, L.; Schulze-Horsel, J.; Reichl, U.: Mathematical model of growth and heterologous hantavirus protein production of the recombinant yeast Saccharomyces cerevisiae. Engineering in Life Sciences 8 (4), pp. 399 - 414 (2008)
  13. 13.
    Sidorenko, Y.; Voigt, A.; Schulze-Horsel, J.; Reichl, U.; Kienle, A.: Stochastic population balance modeling of influenza virus replication in vaccine production processes. II. Detailed description of the replication mechanism. Chemical Engineering Science 63 (8), pp. 2299 - 2304 (2008)
  14. 14.
    Wahl, A.; Sidorenko, Y.; Dauner, M.; Genzel, Y.; Reichl, U.: Metabolic flux model for an anchorage-dependent MDCK cell line: Characteristic Growth Phases and Minimum Substrate Consumption Flux Distribution. Biotechnology and Bioengineering 101 (1), pp. 135 - 152 (2008)
  15. 15.
    Wahl, S. A.; Nöh, K.; Wiechert, W.: 13C labeling experiments at metabolic nonstationary conditions: an exploratory study. BMC Bioinformatics 9, p. 152 (2008)
  16. 16.
    Wolff, M. W.; Reichl, U.: Downstream Processing: From egg to cell culture-derived influenza virus particles. Chemical Engineering and Technology 31 (6), pp. 846 - 857 (2008)

Conference Paper (1)

  1. 17.
    Mueller, T.; Schulze-Horsel, J.; Sidorenko, Y.; Reichl, U.; Kienle, A.: Population balance modeling of influenza virus replication in MDCK cells during vaccine production. In: 18th European Symposium on Computer Aided Process Engineering: ESCAPE 18, Vol. 25, pp. 133 - 138 (Eds. Braunschweig, B.; Joulia, X.). 18th European Symposium on Computer Aided Process Engineering - ESCAPE, Lyon, France, June 01, 2008 - June 04, 2008. (2008)

Talk (17)

  1. 18.
    Balck, A.; Michalzik, M.; Wolff, M. W.; Reichl, U.; Büttgenbache, S.: Influenza Virus Detection in Vaccine Production with a Quartz Crystal Microbalance. Biosensors 2008, Shanghai, China (2008)
  2. 19.
    Kröber, T.; Lehmann, S.; Solf, N.; Zimmermann, A.; Reichl, U.; Wolff, M. W.: Purification of Hemagglutinin from Host Cell Membranes. ISPPP 2008, Baden-Baden, Germany (2008)
  3. 20.
    Opitz, L.; Solf, N.; Reichl, U.; Wolff, M. W.: Sulphated cellulose membranes – an economic virus capturing method for influenza virus purification. AIChE Annual meeting and Centennial celebration 2008, Philadelphia, USA (2008)
  4. 21.
    Rapp, E.: Automated High Throughput Characterization of Carbohydrates and Carbohydrate Mixture Composition Patterns - Utilizing Capillary Gel Electrophoresis with Laser Induced Fluorescence Detection. Meeting with Merck-Serono, Magdeburg, Germany (2008)
  5. 22.
    Rapp, E.; Charvát, A.; Beinsen, A.; Urlaub, H.; Reichl, U.; Seidel-Morgenstern, A.; Abel, B.: Atmospheric Pressure Free Liquid Infrared Matrix Assisted Laser Dispersion Ionisation: Unifying LC-MS Interfaces. 25th (Montreux) Symosium on Liquid Chromatography / Mass Spectrometry, Montreux, Switzerland (2008)
  6. 23.
    Rapp, E.; Schwarzer, J.; Reichl, U.: Characterization of the Influenza A Virus Hemagglutinin Glycosylation Pattern with Respect to Vaccine Production - Utilizing Capillary Gel Electrophoresis with Laser Induced Fluorescence Detection. 24th International Carbohydtrate Symposium (ICS), Oslo, Norway (2008)
  7. 24.
    Rapp, E.: Atmospheric Pressure Free Liquid Infrared MALDI Mass Spectrometry: Towards a unified ESI/MALDI - Liquid Chromatography Interface. MassTech Usermeeting at 56th ASMS, Denver, USA (2008)
  8. 25.
    Rath, A.; Lohr, V.; Genzel, Y.; Schwarzer, J.; Rapp, E.; Sandig, V.; Jordan, I.; Reichl, U.: Influenza and modified vaccinia Ankara (MVA) production in avian designer cells. Bioperspectives, Hannover, Germany (2008)
  9. 26.
    Reichl, U.: Increasing Productivity in Influenza Virus Production: Virus Yields in High Cell Density Cultivations. 2008 AIChE Annual Meeting, Philadelphia, USA (2008)
  10. 27.
    Reichl, U.: A Systems Perspective of Virus Replication in Mammalian Cell Culture. University of Waterloo : Chemical Engineering Seminar, Waterloo, Canada (2008)
  11. 28.
    Riedele, C.; Schmidt, J. K.; Geisler, L.; Reichl, U.: Antibiotic Pulse Experiments of a 3-species Mixed Culture: Experimental Results and Mathematical Modelling. Analysis of Microbial Cells at the Single Cell Level, Bad Schandau, Germany (2008)
  12. 29.
    Vester, D.; Genzel, Y.; Gade, D.; Rapp, E.; Reichl, U.: Virus-host cell interactions in a vaccine production process: Proteomic analysis of influenza A virus infected mammalian cells by 2D-DIGE. Proteomics Europe, Lisboa, Portugal (2008)
  13. 30.
    Wahl, A.; Ritter, J. B.; Genzel, Y.; Reichl, U.: Metabolic flux model for an adherent MDCK cellline: Comparison of flux distributions under different cultivation conditions. Dynamic Systems in Practice Focus : Systems Biology, Magdeburg, Germany (2008)
  14. 31.
    Wolff, M. W.; Siewert, C.; Lehmann, S.; Opitz, L.; Hansen, S. P.; Djurup, R.; Faber, R.; Reichl, U.: Capturing of cell culture derived Vaccinia Virus by membrane adsorbers. AICHE Annual Meeting, Philadelphia, USA (2008)
  15. 32.
    Wolff, M. W.; Siewert, C.; Lehmann, S.; Hansen, S. P.; Djurup, R.; Faber, R.; Reichl, U.: Capturing of cell culture derived Vaccinia Virus by heparin-affinity chromatography. European Symposium on Biochemical Engineering 7, Faro, Portugal (2008)
  16. 33.
    Wolff, M. W.; Venzke, C.; Hansen, S. P.; Djurup, R.; Faber, R.; Reichl, U.: Affinity chromatography of cell culture derived Vaccinia Virus. Vaccine Technology II, Albufeira, Algarve, Portugal (2008)
  17. 34.
    Öncül, A.; Genzel, Y.; Reichl, U.; Thevenin, D.: Characterization of flow conditions in wave bioreactors using CFD. 7th European Symposium on Biochemical Engineering Science – ESBES-7, Faro, Portugal (2008)

Poster (18)

  1. 35.
    Bock, A.; Schulze-Horsel, J.; Schwarzer, J.; Genzel, Y.; Reichl, U.: The influence of elevated oxygen partial pressure on specific virus productivities in an influenza vaccine process. Vaccine Technology II, Albufeira, Portugal (2008)
  2. 36.
    Heynisch, B.; Seitz, C.; Vester, D.; Frensing, T.; Reichl, U.: Systems Biology of Virus-Host Cell Interactions-Signal Transduction during Influenza Virus Replication in MDCK Cells. XIV. International Congress of Virology (IUMS 2008), Istanbul, Turkey (2008)
  3. 37.
    Janke, R.; Wahl, A.; Reichl, U.: Enzyme Activities in Central Carbon Metabolism of MDCK Cells under Different Growth Conditions. BioPerspectives, Hannover, Germany (2008)
  4. 38.
    Janke, R.; Wahl, A.; Reichl, U.: Determination of key enzyme activities in the central carbon metabolism of MDCK cells. ForSys Meeting, Berlin, Germany (2008)
  5. 39.
    Lohr, V.; Rath, A.; Genzel, Y.; Jordan, I.; Sandig, V.; Reichl, U.: Metabolism of avian designer cells during influenza and MVA production. Vaccine Technology II, Albufeira, Portugal (2008)
  6. 40.
    Opitz, L.; Solf, N.; Reichl, U.; Wolff, M. W.: Pseudo-affinity capture of cell culture derived influenza virus particles by sulphated cellulose membranes: an economic tool for vaccine production. ISPPP 2008, Baden-Baden, Germany (2008)
  7. 41.
    Opitz, L.; Solf, N.; Reichl, U.; Wolff, M. W.: Economic pseudo-affinity purification of mammalian cell culture-derived influenza virus particles by sulphated cellulose membranes. European BioPerspectives 2008, Hannover, Germany (2008)
  8. 42.
    Opitz, L.; Solf, N.; Reichl, U.; Wolff, M. W.: Capturing of cell culture derived influenza viruses by sulphated cellulose membranes – a promising pseudo-affinity method for influenza vaccine production. Vaccine Technology II, Albufeira, Portugal (2008)
  9. 43.
    Rapp, E.; Charvát, A.; Beinsen, A.; Urlaub, H.; Abel, B.: Atmospheric Pressure Free Liquid Infrared MALDI Mass Spectrometry: Towards a unified Liquid Chromatography ESI/MALDI MS Interface. 56th American Society for Mass Spectrometry Conference on Mass Spectrometry ans Allied Topics (ASMS), Denver, USA (2008)
  10. 44.
    Riedele, C.; Schmidt, J. K.; Geisler, L.; Reichl, U.: Antibiotic Pulse Experiments of a 3-species Mixed Culture: Experimental Results and Mathematical Modelling. Analysis of Microbial Cells at the Single Cell Level, Bad Schandau, Germany (2008)
  11. 45.
    Riedele, C.; Schmidt, J. K.; Geisler, L.; Reichl, U.: Mathmatische Modelle zur Analyse von Antibiotika-Pulsexperimenten einer 3-Spezies Mischkultur. GVC/Dechema-Tagung: Modellierung: "Von der Zelle zum Prozess", Bremen, Germany (2008)
  12. 46.
    Schwarzer, J.; Rapp, E.; Reichl, U.: Influence of Upstream Process Conditions on Influenza A Virus Hemagglutinin N-Glycosylation Pattern during Vaccine Production. 4th Glycan Forum, Berlin, Germany (2008)
  13. 47.
    Vester, D.; Rapp, E.; Genzel, Y.; Gade, D.; Reichl, U.: Dynamics of the proteomes of mammalian cell lines during influenza A virus infection. HuPo 2008, Amsterdam, The Netherlands (2008)
  14. 48.
    Wahl, A.; Ritter, J.; Janke, R.; Reichl, U.: Metabolic consequences of different media and viral infection of a MDCK cell line. 7th European Symposium on Biochemical Engineering Science (ESBES7), Faro, Portugal (2008)
  15. 49.
    Wahl, A.; Ritter, J.; Janke, R.; Reichl, U.: Tools for Metabolic and Enzymatic Characterization of Mammalian Cell. ForSys Meeting, Berlin, Germany (2008)
  16. 50.
    Wahl, A.; Ritter, J. B.; Genzel, Y.; Reichl, U.: Metabolic Shifts of a MDCK cell line during the early phase of infection. DECHEMA Modellierung : Von der Zelle zum Prozess, Bremen, Germany (2008)
 
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