Head of the Group

Prof. Dr.-Ing. Udo Reichl
Prof. Dr.-Ing. Udo Reichl
Phone: +49 391 6110 201
Fax: +49 391 6110 203
Room: N0.19

Contact Person

Annegret Frauendienst
Phone:+49 391 6110 200Fax:+49 391 6110 203

Group Page

Publications

Publications BPE group

Journal Article (207)

  1. 201.
    Nayak, D. P.; Reichl, U.: Neuraminidase activity assays for monitoring MDCK cell culture derived influenza virus. Journal of Virological Methods 122, pp. 9 - 15 (2004)
  2. 202.
    Sidorenko, Y.; Reichl, U.: A Structured Model of Influenza Virus Replication in MDCK Cells. Biotechnology and Bioengineering 88 (1), pp. 1 - 14 (2004)
  3. 203.
    Tallarek, U.; Rapp, E.; Sann, H.; Reichl, U.; Seidel-Morgenstern, A.: Quantitative study of electrokinetic transport in porous media by confocal laser scanning microscopy. Langmuir 19, pp. 4527 - 4531 (2003)
  4. 204.
    Genzel, Y.; Reichl, U.: Analysis of cell growth, virus replication and medium composition in equine influenza vaccine production. Chemie-Ingenieur-Technik 74 (5), pp. 673 - 674 (2002)
  5. 205.
    Trotha, R.; Reichl, U.; Thies, F. L.; Sperling, D.; Koenig, W.; Koenig, B.: Adaption of a fragment analysis technique to an automated high- throughput multicapillary electrophoresis device for the precise qualitative and quantitative characterization of microbial communities. Electrophoresis 23 (7-8), pp. 1070 - 1079 (2002)
  6. 206.
    Kremling, A.; Bettenbrock, K.; Stelling, J.; Reichl, U.; Gilles, E. D.: Systemorientierte Bioprozesstechnik: interdisziplinäre Forschung in Biologie, System- und Computerwissenschaften. Magdeburger Wissenschaftsjournal 6 (1/2), pp. 29 - 36 (2001)
  7. 207.
    Phillip, W. W. A.; Rosenberg, H.; Schüz, E.; Seilkopf, H.: Zum Zug des Weißstorchs im Gebiet von Rotem Meer, Suesgolf und Kanalzone. Vogelwarte 20, pp. 116 - 121 (1959)

Book (1)

  1. 208.
    Benner, P.; Findeisen, R.; Flockerzi, D.; Reichl, U.; Sundmacher, K. (Eds.): Large-Scale Networks in Engineering and Life Sciences. Springer International Publishing, Switzerland (2014), 388 pp.

Book Chapter (10)

  1. 209.
    Butler, M.; Reichl, U.: Animal Cell Expression Systems. In: Advances in Biochemical Engineering/Biotechnology, pp. 1 - 36. Springer, Cham, Switzerland (2017)
  2. 210.
    Muth, T.; Rapp, E.; Berven, F. S.; Barsnes, H.; Vaudel, M.: Tandem Mass Spectrum Sequencing: An Alternative to Database Search Engines in Shotgun Proteomics. In: Modern Proteomics – Sample Preparation, Analysis and Practical Applications,, pp. 217 - 226 (Eds. Mirzaei, H.; Carrasco, M.). Springer International Publishing, Cham (2016)
  3. 211.
    Hennig, R.; Rapp, E.; Kottler, R.; Cajic, S.; Reichl, U.: N -Glycosylation Fingerprinting of Viral Glycoproteins by xCGE-LIF. In: Carbohydrate-Based Vaccines: Methods and Protocols, pp. 123 - 143. Springer, New York (2015)
  4. 212.
    Kalbfuß, B.; Reichl, U.: Viral Vaccines Purification. In: Vaccine Development and Manufacturing, pp. 97 - 181. John Wiley & Sons, Hobroken, New Jersey (2015)
  5. 213.
    Genzel, Y.; Rödig, J.; Rapp, E.; Reichl, U.: Vaccine production: Upstream processing with adherent or suspension cell lines. In: Animal Cell Biotechnology: Methods and Protocols, pp. 371 - 393 (Ed. Pörtner, R.). HUMANA Press Inc., New York (2014)
  6. 214.
    Merten, O.-W.; Bakker, W. A.M.; Vorlop, J.; Reiter, M.; Visnovsky, G.; Jäger, V.; Merabishvili, M.; Reichl, U.: Virus Production Under Suspension Conditions. In: Industrial Scale Suspension Culture of Living Cells, pp. 503 - 554. Wiley Blackwell, Weinheim (2014)
  7. 215.
    Mangold, M.; Schmidt, J. K.; Tobiska, L.; Tsotsas, E.: Modeling of Membrane Reactors. In: Membrane Reactors: Distributing Reactants to Improve Selectivity and Yield, pp. 29 - 62 (Ed. Seidel-Morgenstern, A.). Wiley-VCH, Weinheim (2010)
  8. 216.
    Genzel, Y.; Reichl, U.: Vaccine production - state of the art and future needs in upstream processing. In: Animal Cell Biotechnology: Methods and Protocols, pp. 457 - 473 (Ed. Pörtner, R.). HUMANA Press Inc., Totowa, New Jersey (2007)
  9. 217.
    Reichl, U.; Sidorenko, Y.: Dynamics of Virus-Host Cell Interaction. In: Bioinformatics: From Genomes to Therapies, pp. 861 - 898 (Ed. Lengauer, T.). Wiley-VCH, Weinheim (2007)
  10. 218.
    Ritter, J. B.; Genzel, Y.; Reichl, U.: Monitoring of Extracellular TCA Cycle Intermediates in Mammalian Cell Culture. In: Cell Technology for Cell Products: Proceedings of the 19th ESACT Meeting, pp. 603 - 605 (Ed. Smith, R.). Springer, Dordrecht, The Netherlands (2007)

Conference Paper (31)

  1. 219.
    Dürr, R.; Duvigneau, S.; Laske, T.; Bachmann, M.; Kienle, A.: Analyzing the Impact of Heterogeneity in Genetically Engineered Cell Lines for Influenza Vaccine Production Using Population Balance Modeling. Foundations of Systems Biology in Engineering - FOSBE 2016 — Magdeburg, Germany, 9—12 October 2016, Magdeburg, Germany, October 09, 2016 - October 12, 2016. IFAC-PapersOnLine 49 (26), pp. 225 - 230 (2016)
  2. 220.
    Kramer, B.; Tüngler, R.; Bettenbrock, K.; Conradi, C.: A compact mathematical model of mandelate racemase production and chaperone overexpression in E. coli. 8th Vienna Interantional Conference on Mathematical Modelling , Vienna, Austria, February 18, 2015 - February 20, 2015. IFAC-PapersOnLine 48 (1), pp. 23 - 28 (2015)
  3. 221.
    Rehberg, M.; Wetzel, M.; Ritter, J.; Reichl, U.: The Regulation of Glutaminolysis and Citric Acid Cycle Activity During Mammalian Cell Cultivation. 12th IFAC Symposium on Computer Applications in Biotechnology - CAB 2013, Mumbai, India, December 16, 2013 - December 18, 2013. IFAC Proceedings Volumes 46 (31), pp. 48 - 53 (2013)
  4. 222.
    Dürr, R.; Müller, T.; Isken, B.; Schulze-Horsel, J.; Reichl, U.; Kienle, A.: Distributed Modeling and Parameter Estimation of Influenza Virus Replication During Vaccine Production. MATHMOD 2012 - 7th Vienna International Conference on Mathematical Modelling, Vienna, Austria, February 15, 2012 - February 17, 2012. IFAC Proceedings Volumes 45 (2), pp. 320 - 325 (2012)
  5. 223.
    Isken, B.; Schulze-Horsel, J.; Bock, A.; Genzel, G.; Reichl, U.: Monitoring of Host-Cell Infection and Virus-Induced Apoptosis in Influenza Vaccine Production. In: ESACT - Proceedings of the 21st Annual meeting of the European Society for animal cell technology (ESACT), pp. 675 - 683 (Eds. Jenkins, N.; Barron, N.; Alves, P.). 21st ESACT Meeting , Dublin, Ireland, June 07, 2009 - June 10, 2009. (2012)
  6. 224.
    Kröber, T.; Wolff, M. W.; Lehmann, S.; Zimmermann, A.; Reichl, U.: Accounting for the Entire Influenza Hemagglutinin during a Flu Vaccine Production Process. In: ESACT - Proceedings of the 21st Annual meeting of the European Society for animal cell technology (ESACT), pp. 685 - 689. 21st ESACT Meeting , Dublin, Ireland, June 07, 2009 - June 10, 2009. Berlin (2012)
  7. 225.
    Lohr, V.; Rath, A.; Jordan, I.; Sandig, V.; Genzel, Y.; Reichl, U.: Avian Designer Cells AGE1.CR as Candidates for MVA and Influenza Vaccine Production. In: ESACT - Proceedings of the 21st Annual meeting of the European Society for animal cell technology (ESACT), pp. 615 - 631 (Eds. Jenkins, N.; Barron, N.; Alves, P.). 21st ESACT Meeting, Dublin, Ireland, June 07, 2009 - June 10, 2009. (2012)
  8. 226.
    Roedig, J.; Rapp, E.; Hennig, R.; Schwarzer, J.; Reichl, U.: Optimized CGE-LIF-based glycan analysis for high-throughput applications. In: ESACT - Proceedings of the 21st Annual meeting of the European Society for animal cell technology (ESACT), pp. 599 - 603 (Eds. Jenkins, N.; Barron, N.; Alves, P.). 21st ESACT Meeting, Dublin, Ireland, June 07, 2009 - June 10, 2009. (2012)
  9. 227.
    Schenkendorf, R.; Mangold, M.; Reichl, U.: Parameter Identification of Time-Delay Systems: A Flatness Based Approach. MATHMOD 2012 - 7th Vienna International Conference on Mathematical Modelling, Vienna, Austria, February 15, 2012 - February 17, 2012. IFAC Proceedings Volumes 45 (2), pp. 165 - 170 (2012)
  10. 228.
    Öncül, A. A.; Genzel, Y.; Reichl, U.; Thévenin, D.: Flow characterization in wave bioreactors using Computational Fluid Dynamics. In: ESACT - Proceedings of the 21st Annual meeting of the European Society for animal cell technology (ESACT), pp. 455 - 469 (Eds. Jenkins, N.; Barron, N.; Alves, P.). 21st ESACT Meeting, Dublin, Ireland, June 07, 2009 - June 10, 2009. Dordrecht (2012)
  11. 229.
    Müller, T.; Dürr, R.; Isken, B.; Schulze-Horsel, J.; Reichl, U.; Kienle, A.: Population balance modelling of influenza virus replication during vaccine prodcution - Influence of apoptosis. In: 21st European Symposium on Computer Aided Process Engineering - Part A, pp. 1336 - 1340 (Eds. Pistikopoulos, E.N.; Georgiadis, M.C.; Kokossis, A.C.). ESCAPE 21 - 21st European Symposium on Computer Aided Process Engineering, Chalkidiki, Greece, May 29, 2011 - June 01, 2011. (2011)
  12. 230.
    Bock, A.; Genzel, Y.; Reichl, U.: Monitoring of Cell activity: online oxygen uptake rates in pulsed aerated cell culture. In: Cells and Culture: Proceedings of the 20th ESACT Meeting, pp. 391 - 396 (Ed. Noll, T.). 20th ESACT Meeting, Dresden, Germany, June 17, 2007 - June 20, 2007. (2010)
  13. 231.
    Genzel, Y.; Dietzsch, C.; Reichl, U.: Comparing Vero and MDCK cells for influenza A virus production in microcarrier systems. In: Cells and Culture: Proceedings of the 20th ESACT Meeting, pp. 635 - 638 (Ed. Noll, T.). 20th ESACT Meeting, Dresden, Germany, June 17, 2007 - June 20, 2007. (2010)
  14. 232.
    Ritter, J. B.; Genzel, Y.; Reichl, U.: Metabolite Analysis in Mammalian Cells: How to generate reliable data sets? In: Cells and Culture: Proceedings of the 20th ESACT Meeting, pp. 397 - 406 (Ed. Noll, T.). 20th ESACT Meeting, Dresden, Germany, June 17, 2007 - June 20, 2007. (2010)
  15. 233.
    Schulze-Horsel, J.; Schulze, M.; Genzel, Y.; Reichl, U.: Single-cell approach in influenza vaccine production: apoptosis and virus protein production. In: Cells and Culture: Proceedings of the 20th ESACT Meeting, pp. 25 - 28 (Ed. Noll, T.). 20th ESACT Meeting, Dresden, Germany, June 17, 2007 - June 20, 2007. (2010)
  16. 234.
    Schwarzer, J.; Rapp, E.; Reichl, U.: Glycosylation of Influenza A Virus Hemagglutinin. In: Cells and Culture: Proceedings of the 20th ESACT Meeting, pp. 621 - 624 (Ed. Noll, T.). 20th ESACT Meeting, Dresden, Germany, June 17, 2007 - June 20, 2007. (2010)
  17. 235.
    Vester, D.; Rapp, E.; Genzel, Y.; Gade, D.; Reichl, U.: Proteomic analysis of influenza A virus infected mammalian cells by 2D-DIGE. In: Cells and Culture: Proceedings of the 20th ESACT Meeting, pp. 429 - 432 (Ed. Noll, T.). 20th ESACT Meeting, Dresden, Germany, June 17, 2007 - June 20, 2007. (2010)
  18. 236.
    Wahl, A.; Sidorenko, Y.; Genzel, Y.; Reichl, U.: Metabolic flux distribution during growth of adherent growing MDCK cells in different media. In: Cells and Culture: Proceedings of the 20th ESACT Meeting, pp. 459 - 462 (Ed. Noll, T.). 20th ESACT Meeting, 2007-06-17, June 20, 2007. (2010)
  19. 237.
    Öncül, A.A.; Janiga, G.; Genzel, Y.; Reichl, U.; Thévenin, D.: Two-population CFD simulation: microcarrier system for adherent cell growth in Wave Bioreactors. In: 4th International Conference on Population Balance Modelling: PBM 2010, pp. 667 - 681. 4th International Conference on Population Balance Modelling, Berlin, Germany, September 15, 2010 - September 17, 2010. (2010)
  20. 238.
    Mueller, T.; Schulze-Horsel, J.; Sidorenko, Y.; Reichl, U.; Kienle, A.: Population balance modeling of influenza virus replication in MDCK cells during vaccine production. In: 18th European Symposium on Computer Aided Process Engineering: ESCAPE 18, Vol. 25, pp. 133 - 138 (Eds. Braunschweig, B.; Joulia, X.). 18th European Symposium on Computer Aided Process Engineering - ESCAPE, Lyon, France, June 01, 2008 - June 04, 2008. (2008)
  21. 239.
    Bock, A.; Reichl, U.: Closed loop control of perfusion systems in high-density cell culture. In: Cell Technology for Cell Products: Proceedings of the 19th ESACT Meeting, pp. 549 - 551 (Ed. Smith, R.). 19th ESACT Meeting, Harrogate, UK, June 05, 2005 - June 08, 2005. Springer, Dordrecht, The Netherlands (2007)
  22. 240.
    Genzel, Y.; Fischer, M.; Olmer, R. M.; Schäfer, B.; Best, C.; König, S.; Hundt, B.; Reichl, U.: Serum-free influenza vaccine production with MDCK cells in wave-bioreactor and 5L-stirred tank bioreactor. In: Cell Technology for Cell Products: Proceedings of the 19th ESACT Meeting, pp. 563 - 565 (Ed. Smith, R.). 19th ESACT Meeting , Harrogate, UK, June 05, 2005 - June 08, 2005. Springer, Dordrecht, The Netherlands (2007)
  23. 241.
    Genzel, Y.; Schulze-Horsel, J.; Möhler, L.; Sidorenko, Y.; Reichl, U.: Influenza Vaccines: Challenges in Mammalian Cell Culture Technology. In: Cell Technology for Cell Products: Proceedings of the 19th ESACT Meeting, pp. 503 - 508 (Ed. Smith, R.). 19th ESACT Meeting, Harrogate, UK, June 05, 2005 - June 08, 2005. Springer, Dordrecht, The Netherlands (2007)
  24. 242.
    Hundt, B.; Straube, S.; Schlawin, N.; Kaßner, H.; Reichl, U.: Cultivation of E-FL in Perfusion Mode Using Wave Bioreactor and Stirre-Tank Reactor for Parvovirus Vaccine Production. In: Cell Technology for Cell Products: Proceedings of the 19th ESACT Meeting, pp. 519 - 522 (Ed. Smith, R.). 19th ESACT Meeting, Harrogate, UK, June 05, 2005 - June 08, 2005. Springer, Dordrecht, The Netherlands (2007)
  25. 243.
    Pohlscheidt, M.; Langer, U.; Bödeker, B.; Paulsen, D.; Rübsamen-Waigmann, H.; Reichl, U.; Henzler, H. J.; Apeler, H.: Strategies for Large Scale Production of Parapoxvirus Ovis NZ-2. In: Cell Technology for Cell Products: Proceedings of the 19th ESACT Meeting, pp. 707 - 710 (Ed. Smith, R.). 19th ESACT Meeting, Harrogate, UK, June 05, 2005 - August 06, 2005. Springer, Dordrecht, The Netherlands (2007)
  26. 244.
    Reichl, U.: Biological Fundamentals, Models and Technologies for Vaccine Production. In: Perspectives of Research - Identification and Implementation of Research Topics by Organizations: Ringberg-Symposium Mai 2006, Vol. 7, pp. 191 - 208. Ringberg-Symposium, Kreuth, Germany, May 03, 2006 - May 05, 2006. (2007)
  27. 245.
    Schulze-Horsel, J.; Genzel, Y.; Reichl, U.: Monitoring of Cell Physiology in Influenza Vaccine Production by Flow Cytometry. In: Cell Technology for Cell Products: Proceedings of the 19th ESACT Meeting, pp. 531 - 533 (Ed. Smith, R.). 19th ESACT Meeting, Harrogate, UK, June 05, 2005 - August 06, 2005. Springer, Dordrecht, The Netherlands (2007)
  28. 246.
    Genzel, Y.; Alt, R.; Reichl, U.: Glutamine-free media for vaccine production processes. In: Animal Cell Technology meets Genomics: Proceedings ot the 18th ESACT Meeting, pp. 767 - 770 (Eds. Godia, F.; Fussenegger, M.). 18th ESACT Meeting , Granada, Spain, May 11, 2003 - May 14, 2003. (2005)
  29. 247.
    Hundt, B.; Schänzler, A.; Reichl, U.: Serum free cultivation of primary chicken embryo fibroblasts in microcarrier systems for vaccine production. In: Animal Cell Technology Meets Genomics: Proceedings of the 18th ESACT Meeting, pp. 771 - 774. 18th ESACT Meeting, Granada, Spain, May 11, 2003 - May 14, 2003. (2005)
  30. 248.
    Reichl, U.; Genzel, Y.; Möhler, L.; Sidorenko, Y.; Sann, H.: Animal cell cultures for the production of viral vaccines. In: GVC/DECHEMA Vortrags- und Diskussiontagung "Zellkulturen: vom biologischen System zum Produktionsprozess", pp. 32 - 35. GVC/DECHEMA : Vortrags- und Diskussionstagung, Bad Dürkheim, Deutschland, May 26, 2003 - May 28, 2003. (2003)
  31. 249.
    Genzel, Y.; Voges, L.; Reichl, U.: Development of bioprocess concepts on vaccine production: influenza virus as an example. In: Animal cell technology: from target to market, pp. 344 - 346 (Eds. Lindner-Olsson, E.; Chatzissavidou, N.; Luellau, E.). 17th ESACT Meeting, Tylösand, Sweden, June 10, 2001 - June 14, 2001. (2001)

Meeting Abstract (34)

  1. 250.
    Tapia, F.; Genzel, Y.; Reichl, U.; Sandig, V.: Stirred tanks in cascades and plug-flow tubular bioreactors for continuous production of viral vaccines. In: ECI Symposium Series. Integrated Continuous Biomanufacturing III, Cascais, Portugal, September 17, 2017 - September 21, 2017. (2017)
 
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