Head of the Group

Prof. Dr.-Ing. Udo Reichl
Prof. Dr.-Ing. Udo Reichl
Phone: +49 391 6110 201
Fax: +49 391 6110 203

Contact Person

Annegret Frauendienst
Phone: +49 391 6110 200
Fax: +49 391 6110 203

Group Page

Publications

Publications BPE group

Journal Article (21)

  1. 2016
    Bachmann, M.; Breitwieser, T.; Lipps, C.; Wirth, D.; Jordan, I.; Reichl, U.; Frensing, T.: Impaired antiviral response of adenovirus-transformed cell lines supports virus replication. Journal of General Virology 97 (2), pp. 293 - 298 (2016)
  2. Bensmann, A.; Hanke-Rauschenbach, R.; Heyer, R.; Kohrs, F.; Benndorf, D.; Kausmann, R.; Plöchl, M.; Heiermann, M.; Reichl, U.; Sundmacher, K.: Diagnostic Concept for Dynamically Operated Biogas Production Plants. Renewable Energy 96 (Part A), pp. 479 - 489 (2016)
  3. Cammann, C.; Rath, A.; Reichl, U.; Lingel, H.; Brunner-Weintierl, M.; Simeoni, L.; Schraven, B.; Lindquist, J. A.: Early changes in the metabolic profile of activated CD8+ T cells. BMC Biology 17 (1), 28 (2016)
  4. Frensing, T.; Kupke, S. Y.; Bachmann, M.; Fritzsche, S.; Gallo Ramirez, L. E.; Reichl, U.: Influenza virus intracellular replication dynamics, release kinetics, and particle morphology during propagation in MDCK cells. Applied Microbiology and Biotechnology 100 (16), pp. 7181 - 7192 (2016)
  5. Hennig, R.; Cajic, S.; Borowiak, M.; Hoffmann, M.; Kottler, R.; Reichl, U.; Rapp, E.: Towards personalized diagnostics via longitudinal study of the human plasma N-glycome. Biochimica et Biophysica Acta (BBA) - General Subjects 1860 (8), pp. 1728 - 1738 (2016)
  6. Heyer, R.; Benndorf, D.; Kohrs, F.; De Vrieze, J.; Boon, N.; Hoffmann, M.; Rapp, E.; Schlüter, A.; Sczyrba, A.; Reichl, U.: Proteotyping of biogas plant microbiomes separates biogas plants according to process temperature and reactor type. Biotechnology for Biofuels 9 (9), 155 (2016)
  7. Hoffmann, M.; Marx, K.; Reichl, U.; Wuhrer, M.; Rapp, E.: Site-specific O-Glycosylation Analysis of Human Blood Plasma Proteins. Molecular and Cellular Proteomics 15 (2), pp. 624 - 641 (2016)
  8. Kluge, S.; Genzel, Y.; Laus, K.; Serve, A.; Pflugmacher, A.; Peschel, B.; Rapp, E.; Reichl, U.: Ezrin and HNRNP expression correlate with increased virus release rate and early onset of virus-induced apoptosis of MDCK suspension cells. Biotechnology Journal 11 (10), pp. 1332 - 1342 (2016)
  9. Koch, S.; Benndorf, D.; Fronk, K.; Reichl, U.; Klamt, S.: Predicting compositions of microbial communities from stoichiometric models with applications for the biogas process. Biotechnology for Biofuels (9), 17 (2016)
  10. Laske, T.; Heldt, F. S.; Hoffmann, H.; Frensing, T.; Reichl, U.: Modeling the intracellular replication of influenza A virus in the presence of defective interfering RNAs. Virus Research 213, pp. 90 - 99 (2016)
  11. Laske, T.; Heldt, S.; Hoffmann, H.; Frensing, T.; Reichl, U.: Reprint of “Modeling the intracellular replication of influenza A virus in the presence of defective interfering RNAs. Virus Research 218, pp. 86 - 95 (2016)
  12. Meininger, M.; Stepath, M.; Hennig, R.; Cajic, S.; Rapp, E.; Rotering, H.; Wolff, M. W.; Reichl, U.: Sialic acid-specific affinity chromatography for the separation of erythropoietin glycoforms using serotonin as a ligand. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 1012-1013, pp. 193 - 203 (2016)
  13. Pieler, M.; Frentzel, S.; Bruder , D.; Wolff, M. W.; Reichl, U.: A cell culture-derived whole virus influenza A vaccine based on magnetic sulfated cellulose particles confers protection in mice against lethal influenza A virus infection. Vaccine 34 (50), pp. 6367 - 6374 (2016)
  14. Rodrigues, A. F.; Guerreiro , M. R.; Formas-Oliveira, A. S.; Fernandes, P.; Blechert, A.-K.; Genzel, Y.; Alves, P.M.; Hu , W.S.; Coroadinha, A.S.: Increased titer and reduced lactate accumulation in recombinant retrovirus production through the down-regulation of HIF1 and PDK. Biotechnology and Bioengineering 113 (1), pp. 150 - 162 (2016)
  15. Salerno, C.; Benndorf, D.; Kluge, S.; Palese, L. L.; Reichl, U.; Pollice, A.: Metaproteomics Applied to Activated Sludge for Industrial Wastewater Treatment Revealed a Dominant Methylotrophic Metabolism of Hyphomicrobium zavarzinii. Microbial Ecology 72 (1), pp. 9 - 13 (2016)
  16. Struwe, W.B.; Agravat, S.; Aoki-Kinoshita, K.F.; Campbell, M.P.; Costello, C.E.; Dell, A.; Ten, F.; Haslam, S.M.; Karlsson, N.G.; Khoo, K.H. et al.; Kolarich, D.; Liu, Y.; McBride , R.; Novotny, M.V.; Packer, N.H.; Paulson, J.C.; Rapp, E.; Ranzinger, R.; Rudd, P.M.; Smith, D.F.; Tiemeyer, M.; Wells , L.; York, W.S.; Zaia, J.; Kettner, C.: The minimum information required for a glycomics experiment (MIRAGE) project: sample preparation guidelines for reliable reporting of glycomics datasets. Glycobiology 26 (9), pp. 907 - 910 (2016)
  17. Tanca, A.; Palomba, A.; Fraumene, C.; Pagnozzi, D.; Manghina, V.; Deligios, M.; Muth, T.; Rapp, E.; Martens, L.; Addis, M. F. et al.; Uzzau, S.: The impact of sequence database choice on metaproteomic results in gut microbiota studies. Microbiome 4, 51 (2016)
  18. Tapia, F.; Vázquez-Ramirez, D.; Genzel, Y.; Reichl, U.: Bioreactors for high cell density and continuous multi-stage cultivations: options for process intensification in cell culture-based viral vaccine production. Applied Microbiology and Biotechnology 100 (5), pp. 2121 - 2132 (2016)
  19. Thiesler, C. T.; Cajic, S.; Hoffmann, D.; Thiel, C.; van Diepen, L.; Hennig, R.; Sgodda, M.; Weißmann, R.; Reichl, U.; Steinemann, D. et al.; Diekmann, U.; Huber, N. M. B.; Oberbeck, A.; Cantz, T.; Kuss, A. W.; Körner, C.; Schambach, A.; Rapp, E.; Buettner, F. F. R.: Glycomic Characterization of Induced Pluripotent Stem Cells Derived from a Patient Suffering from Phosphomannomutase 2 Congenital Disorder of Glycosylation (PMM2-CDG). Molecular and Cellular Proteomics 15 (4), pp. 1435 - 1452 (2016)
  20. Wang, W.; Voigt, A.; Wolff, M. W.; Reichl, U.; Sundmacher, K.: Binding kinetics and multi-bond: Finding correlations by synthesizing interactions between ligand-coated bionanoparticles and receptor surfaces. Analytical Biochemistry 505, pp. 8 - 17 (2016)
  21. Weigel, T.; Solomaier, T.; Wehmeyer, S.; Peuker, A.; Wolff, M. W.; Reichl, U.: A membrane-based purification process for cell culture-derived influenza A virus. Journal of Biotechnology 220, pp. 12 - 20 (2016)

Book Chapter (1)

  1. Muth, T.; Rapp, E.; Berven, F. S.; Barsnes, H.; Vaudel, M.: Tandem Mass Spectrum Sequencing: An Alternative to Database Search Engines in Shotgun Proteomics. In: Modern Proteomics – Sample Preparation, Analysis and Practical Applications,, pp. 217 - 226 (Eds. Mirzaei, H.; Carrasco, M.). Springer International Publishing, Cham (2016)

Conference Paper (1)

  1. Dürr, R.; Duvigneau, S.; Laske, T.; Bachmann, M.; Kienle, A.: Analyzing the Impact of Heterogeneity in Genetically Engineered Cell Lines for Influenza Vaccine Production Using Population Balance Modeling. Foundations of Systems Biology in Engineering - FOSBE 2016 — Magdeburg, Germany, 9—12 October 2016, Magdeburg, Germany, October 09, 2016 - October 12, 2016. IFAC-PapersOnLine 49 (26), pp. 225 - 230 (2016)

Talk (20)

  1. Benndorf, D.; Kohrs, F.; Heyer, R.; Becher, B.; Rapp, E.; De Vrieze , J.; Schlüter, A.; Sczyrba, A.; Boon, N.; Reichl, U.: High-throughput metaproteomics of biogas plants. Symposium on Advances and Applications in Metaproteomics, Magdeburg, Germany (2016)
  2. Benndorf, D.; Heyer, R.; Schallert, K.; Muth, T.; Rapp, E.; Reichl, U.: In-depth metaproteomics of a biogas plant operating at high ammonia nitrogen concentrations. Biogas Science 2016, Szeged, Hungary (2016)
  3. Gallo Ramirez, L. E.: Engineered cell lines for influenza vaccine production. 1st ESACT Frontiers Retreat, Lyon, France (2016)
  4. Genzel, Y.; Vazquez-Ramirez, D.; Tapia, F.; Jordan, I.; Reichl, U.: Hollow Fiber-Based High-Cell-Density and Two-stage Bioreactor Continuous Cultivation: Options and limits Towards Process Intensification for Virus Production. Vaccine Technology VI, Albufeira, Portugal (2016)
  5. Genzel, Y.; Tapia, F.; Vazquez-Ramirez, D.; Jordan, I.; Bürgin, T.; Gangemi, D. J.; Reichl, U.: Bioreactor options for continuous cell culture-derived viral vaccine production: less defective interfering particles through process intensification. BioTech 2016: Biopharmaceutical Manufacturing and Single-Use Technologies, Waedenswil, Switzerland (2016)
  6. Genzel, Y.: ESACT Course on Cell Culture-based Viral Vaccines: Upstream Process Intensification. ESACT Course 2016, Llafranc, Spain (2016)
  7. Genzel, Y.: Bioreactor options for continuous cell culture-derived viral vaccine production: lessons on defective interfering particles by process intensification. Advanced Course on Cell Culture (CACC), Cuernavaca, Morelos, Mexico (2016)
  8. Heyer, R.; Benndorf, D.; Kohrs, F.; De Vrieze, J.; Boon, N.; Hoffmann, M.; Rapp, E.; Schlüter, A.; Sczyrba, A.; Reichl, U.: Proteotyping of biogas plant microbiomes. Annual Conference of the Association for General and Applied Microbiology (VAAM), Jena, Germany (2016)
  9. Kohrs, F.; Heyer, R.; Benndorf, D.; Bissinger, T.; Kottler, R.; Fronk, K.; Rapp, E.; Reichl, U.: Kultivierung und Metaproteomanalyse anaerober mikrobieller Gemeinschaften. 23. SIMBA-Treffen, Havelberg, Germany (2016)
  10. Kupke, S. Y.; Heldt, S.; Frensing, T.; Reichl, U.: Single-Cell Analysis of Influenza A Virus-Infected Cells. 26th Annual Meeting of the Society for Virology, Münster, Germany (2016)
  11. Kupke, S. Y.; Heldt, S.; Frensing, T.; Reichl, U.: Heterogeneity in Influenza A Virus Infection Unveiled by Single-Cell Analysis and Stochastic Mathemeatical Modeling. Single Cell Technologies 2016, Frankfurt/Main (2016)
  12. Kupke, S. Y.; Heldt, S.; Frensing, T.; Reichl, U.: Single-Cell Analysis of Influenza A Virus-Infected Cells for the Optimization of Cell Culture-Based Vaccine Production. Vaccine Technology VI, Albufeira, Portugal (2016)
  13. Laske, T.; Bachmann, M.; Frensing, T.; Reichl, U.: Model-based analysis of influenza A virus replication in genetically modified cell lines elucidates virus-host cell interactions. 1st ESACT Frontiers Retreat, Lyon, France (2016)
  14. Marichal-Gallardo, P.; Pieler, M.; Wolff, M. W.; Reichl, U.: Purification of cell culture-based influenza virus particles using membrane filters with the aid of non-ionic polymers. PREP: Preparative and Process Chromatography Symposium 2016, Philadelphia, USA (2016)
  15. Marichal-Gallardo, P.; Pieler, M.; Boerner, K.; Riedel, D.; Wolff, M. W.; Reichl, U.; Grimm, D.: Disposable membrane adsorbers for size-based chromatographic purification of virus particles & gene therapy vectors. ÄKTA User Day 2016, Berlin, Germany (2016)
  16. Marichal-Gallardo, P.; Pieler, M.; Riedel, D.; Wolff, M. W.; Reichl, U.: Purification of cell culture-based influenza A virus particles with a cellulose membrane adsorber and polyethylene glycol. International Symposium on the Separation of Proteins, Peptides, and Polynucleotides (ISPPP) 2016, Salzburg, Austria (2016)
  17. Pieler, M.; Hennig, R.; Gebert, N.; Rapp, E.; Wolff, M. W.; Reichl, U.: Comparison of protein and glyco patterns of cell culture-derived influenza viruses purified by pseudo affinity ligands. 12th International PhD Seminar on Chromatographic Separation Science, Schleiden (2016)
  18. Pieler, M.; Serve, A.; Hennig, R.; Vazquez-Ramirez, D.; Wolff, M. W.; Reichl, U.: Virus Particle Purification Using Magnetic Sulfated Cellulose Particles. Himmelfahrtstagung: New Frontiers for Biotech-Processes, Rhein-Mosel-Halle Koblenz/Germany (2016)
  19. Reichl, U.; Vazquez-Ramirez, D.; Tapia, F.; Jordan, I.; Sandig, V.; Genzel, Y.: Process options for high yield vaccine production. Cell Culture Engineering XV, Palms Springs, USA (2016)
  20. Vazquez-Ramirez, D.; Nikolay, A.; Behrendt, I.; Jordan, I.; Bürgin, T.; Genzel, Y.; Reichl, U.: High-cell-density cultivations by hollow fiber-based perfusion for intensified viral vaccine production. VII SLATCC meeting , Cocoyoc, Morelos, Mexico (2016)

Poster (25)

  1. Benndorf, D.; Becher, B.; Kohrs, F.; Heyer, R.; Rapp, E.; Schlüter, A.; Sczyrba, A.: An optimized bioinformatic workflow for of biogas plants. VAAM Jahrestagung, Jena, Germany (2016)
  2. Benndorf, D.; Heyer, R.; Kohrs, F.; Schallert, K.; Muth, T.; Reichl, U.: The MetaProteomeAnalyzer software provides a complete workflow for analysis of metaproteomic data in microbiome research. International de.NBI-Symposium "Bioinformatics for Human Health & Disease", Heidelberg, Germany (2016)
  3. Benndorf, D.; Becher, B.; Kohrs, F.; Heyer, R.; Rapp, E.; Schlüter, A.; Sczyrba, A.; Reichl, U.: An optimized bioinformatic workflow for metaproteomics of biogas plants. Annual Conference of the Association for General and Applied Microbiology (VAAM), Jena, Germany (2016)
  4. Cajic, S.; Hennig, R.; Reichl, U.; Rapp, E.: Exploring the Complex World of Sialic Acids by xCGE-LIF. Frontiers in Sialic Acid Research Conference (SIAREC), Bad Lauterberg, Germany (2016)
  5. Dürr, R.; Duvigneau, S.; Laske, T.; Bachmann, M.; Kienle, A.: Analyzing the impact of heterogeneity in genetically engineered cell lines for influenza vaccine production using population balance modeling. 6th IFAC Conference on Foundations of Systems Biology in Engineering (FOSBE), Magdeburg, Germany (2016)
  6. Fischer, L.M.; Ilhan, S.; Wolff, M. W.; Reichl, U.: Purification of Influenza Virus via Continuous Chromatography. Vaccine Technology Albufeira 2016, Albufeira, Portugal (2016)
  7. Fortuna, A. R.; Teeffelen, S. v.; Taft, F.; Villain, L.; wolff, M. W.; Reichl, U.: Optimization of sulfated cellulose membrane adsorbers for the purification of influenza virus. Vaccine Technology Albufeira 2016, Albufeira, Portugal (2016)
 
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