Head of the Group

Prof. Dr.-Ing. Udo Reichl
Prof. Dr.-Ing. Udo Reichl
Phone: +49 391 6110 201
Fax: +49 391 6110 203

Contact Person

Annegret Frauendienst
Phone: +49 391 6110 200
Fax: +49 391 6110 203

Group Page

Publications

Publications BPE group

Journal Article (28)

  1. 2013
    Bakovic, M.P.; Selman, M.H.J.; Hoffmann, M.; Rudan, I.; Campbell, H.; Deelder, A.M.; Lauc, G.; Wuhrer, M.: High-Throughput IgG Fc N-Glycosylation Profiling by Mass Spectrometry of Glycopeptides. Journal of Proteome Research 12 (2), pp. 821 - 831 (2013)
  2. Behne, A.; Muth, T.; Borowiak, M.; Reichl, U.; Rapp, E.: glyXalign: High-throughput migration time alignment preprocessing of electrophoretic data retrieved via multiplexed capillary gel electrophoresis with laser-induced fluorescence detection-based glycoprofiling. Electrophoresis 34 (16), pp. 2311 - 2315 (2013)
  3. Borchers, S.; Freund, S.; Rath, A.; Streif, S.; Reichl, U.; Findeisen, R.: Identification of Growth Phases and Influencing Factors in Cultivations with AGE1.HN Cells Using Set-Based Methods. PLoS One 8 (8), p. e68124 (2013)
  4. Bunz, S.-C.; Rapp, E.; Neusüss, C.: Capillary Electrophoresis/Mass Spectrometry of APTS-Labeled Glycans for the Identification of Unknown Glycan Species in Capillary Electrophoresis/Laser-Induced Fluorescence Systems. Analytical Chemistry 85 (21), pp. 10218 - 10224 (2013)
  5. Frensing, T.; Heldt, S.; Pflugmacher, A.; Behrendt, I.; Jordan, I.; Flockerzi, D.; Genzel, Y.; Reichl, U.: Continuous Influenza Virus Production in Cell Culture Shows a Periodic Accumulation of Defective Interfering Particles. PLoS One 8 (9), p. e72288 (2013)
  6. Freund, S.; Rath, A.; Barradas, O. P.; Skerhutt, S.; Scholz, S.; Niklas, J.; Sandig, V.; Rose, T.; Heinzle, E.; Noll, T. et al.; Pörtner, R.; Zeng, A. P.; Reichl, U.: Batch-to-batch variability of two human designer cell lines - AGE1.HN and AGE1.HN.AAT - carried out by different laboratories under defined culture conditions using a mathematical model. Engineering in Life Sciences 13 (6), pp. 580 - 592 (2013)
  7. Genzel, Y.; Behrendt, I.; Rödig, J.; Rapp, E.; Kueppers, C.; Kochanek, S.; Schiedner, G.; Reichl, U.: CAP, a new human suspension cell line for influenza virus production. Applied Microbiology and Biotechnology 97 (1), pp. 111 - 122 (2013)
  8. Genzel, Y.; Frensing, T.; Reichl, U.: Herstellung moderner Grippeimpfstoffe: Zellkultur statt Hühnerei. Chemie in unserer Zeit 47 (1), pp. 12 - 22 (2013)
  9. Hanreich, A.; Schimpf, U.; Zakrzewski, M.; Schlüter, A.; Benndorf, D.; Heyer, R.; Rapp, E.; Puhler, A.; Reichl, U.; Klocke, M.: Metagenome and metaproteome analyses of microbial communities in mesophilic biogas-producing anaerobic batch fermentations indicate concerted plant carbohydrate degradation. Systematic and Applied Microbiology 36 (5), pp. 330 - 338 (2013)
  10. Heldt, S.; Frensing, T.; Pflugmacher, A.; Gröpler, R.; Peschel, B.; Reichl, U.: Multiscale Modeling of Influenza A Virus Infection Supports the Development of Direct-Acting Antivirals. PLoS Computational Biology 9 (11), p. e1003372 (2013)
  11. Heyer, R.; Kohrs, F.; Benndorf, D.; Rapp, E.; Kausmann, R.; Heiermann, M.; Klocke, M.; Reichl, U.: Metaproteome analysis of the microbial communities in agricultural biogas plants. New biotechnology 30 (6), pp. 614 - 622 (2013)
  12. Hädicke, O.; Lohr, V.; Genzel, Y.; Reichl, U.; Klamt, S.: Evaluating differences of metabolic performances: Statistical methods and their application to animal cell cultivations. Biotechnology and Bioengineering 110 (10), pp. 2633 - 2642 (2013)
  13. Hütter, J.; Rödig, J. V.; Höper, D.; Seeberger, P. H.; Reichl, U.; Rapp, E.; Lepenies, B.: Toward Animal Cell Culture-based Influenza Vaccine Design: Viral Hemagglutinin N-Glycosylation Markedly Impacts Immunogenicity. The Journal of Immunology 190 (1), pp. 220 - 230 (2013)
  14. Jordan, I.; Lohr, V.; Genzel, Y.; Reichl, U.; Sandig, V.: Elements in the Development of a Production Process for Modified Vaccinia Virus Ankara. Microorganisms 1 (1), pp. 100 - 121 (2013)
  15. Kluge, S.; Rourou, S.; Vester, D.; Majoul, S.; Benndorf, D.; Genzel, Y.; Rapp, E.; Kallel, H.; Reichl, U.: Proteome analysis of virus-host cell interaction: rabies virus replication in Vero cells in two different media. Applied Microbiology and Biotechnology 97 (12), pp. 5493 - 5506 (2013)
  16. Kolarich, D.; Rapp, E.; Struwe, W. B.; Haslam, S. M.; Zaia, J.; McBride, R.; Agravat, S.; Campell, M. P.; Kato, M.; Ranzinger, R. et al.; Kettner, C.; York, W. S.: The Minimum Information Required for a Glycomics Experiment (MIRAGE) Project: Improving the Standards for Reporting Mass-spectrometry-based Glycoanalytic Data. Molecular and Cellular Proteomics 12 (4), pp. 991 - 995 (2013)
  17. Kottler, R.; Mank, M.; Hennig, R.; Müller-Werner, B.; Stahl, B.; Reichl, U.; Rapp, E.: Development of a high-throughput glycoanalysis method for the characterization of oligosaccharides in human milk utilizing multiplexed capillary gel electrophoresis with laser-induced fluorescence detection. Electrophoresis 34 (16), pp. 2323 - 2336 (2013)
  18. Kröber, T.; Wolff, M. W.; Hundt, B.; Seidel-Morgenstern, A.; Reichl, U.: Continuous purification of influenza virus using simulated moving bed chromatography. Journal of Chromatography A 1307, pp. 99 - 110 (2013)
  19. Muth, T.; Benndorf, D.; Reichl, U.; Rapp, E.; Martens, L.: Searching for a needle in a stack of needles: challenges in metaproteomics data analysis. Molecular BioSystems 9 (4), pp. 578 - 585 (2013)
  20. Muth, T.; Peters, J.; Blackburn, J.; Rapp, E.; Martens, L.: ProteoCloud: A full-featured open source proteomics cloud computing pipeline. Journal of Proteomics 88 (Special Issue: New Horizons and Applications for Proteomics [EuPA 2012]), pp. 104 - 108 (2013)
  21. Müller, T.; Dürr, R.; Isken, B.; Schulze-Horsel, J.; Reichl, U.; Kienle, A.: Distributed modeling of human influenza a virus-host cell interactions during vaccine production. Biotechnology and Bioengineering 110 (8), pp. 2252 - 2266 (2013)
  22. Neumann, A.; Hoyer, W.; Wolff, M. W.; Reichl, U.; Pfitzner, A.; Roth, B.: New method for density determination of nanoparticles using a CPS disc centrifuge (TM). Colloids and Surfaces B: Biointerfaces 104, pp. 27 - 31 (2013)
  23. Peschel, B.; Frentzel, S.; Laske, T.; Genzel, Y.; Reichl, U.: Comparison of influenza virus yields and apoptosis-induction in an adherent and a suspension MDCK cell line. Vaccine 31 (48), pp. 5693 - 5699 (2013)
  24. Rehberg, M.; Ritter, J. B.; Genzel, Y.; Flockerzi, D.; Reichl, U.: The relation between growth phases, cell volume changes and metabolism of adherent cells during cultivation. Journal of Biotechnology 164 (4), pp. 489 - 499 (2013)
  25. Rodriguez-Fernandez, M.; Rehberg, M.; Kremling, A.; Banga, J. R.: Simultaneous model discrimination and parameter estimation in dynamic models of cellular systems. BMC Systems Biology 7, 76 (2013)
  26. Rödig, J. V.; Rapp, E.; Bohne, J.; Kampe, M.; Kaffka, H.; Bock, A.; Genzel, Y.; Reichl, U.: Impact of Cultivation Conditions on N-glycosylation of Influenza Virus A Hemagglutinin Produced in MDCK Cell Culture. Biotechnology and Bioengineering 110 (6), pp. 1691 - 1703 (2013)
  27. Stavenhagen, K.; Hinneburg, H.; Thaysen-Andersen, M.; Hartmann, L.; Silva, D. V.; Fuchser, J.; Kaspar, S.; Rapp, E.; Seeberger, P. H.; Kolarich, D.: Quantitative mapping of glycoprotein micro-heterogeneity and macro-heterogeneity: An evaluation of mass spectrometry signal strengths using synthetic peptides and glycopeptides. Journal of Mass Spectrometry 48 (6), pp. 627 - 639 (2013)
  28. Tung, S.; Shi, Y.; Wong, K.; Zhu, F.; Gorczynski, R.; Laister, R.; Minden, M.; Blechert, A.-K.; Genzel, Y.; Reichl, U. et al.; Spaner, D. E.: PPARalpha and fatty acid oxidation mediate glucocorticoid resistance in chronic lymphocytic leukemia. Blood 122 (6), pp. 969 - 980 (2013)

Conference Paper (1)

  1. Rehberg, M.; Wetzel, M.; Ritter, J.; Reichl, U.: The Regulation of Glutaminolysis and Citric Acid Cycle Activity During Mammalian Cell Cultivation. In: Computer Applications in Biotechnology - CAB 2013, Vol. 12, pp. 48 - 53. 12th IFAC Symposium on Computer Applications in Biotechnology - CAB 2013, Mumbai, India, December 16, 2013 - December 18, 2013. (2013)

Talk (25)

  1. Benndorf, D.; Kohrs, F.; Magnussen, A.; Heyer, R.; Rapp, E.; Kausmann, R.; Heierman, M.; Klocke, M.; Reichl, U.: Metaproteomics for process monitoring of biogas plants. 8th International Symposium on Anaerobic Microbiology (ISAM8), Innsbruck, Austria (2013)
  2. Benndorf, D.; Kuhn, R.; Kohrs, F.; Schlegel, T.; Palese, L.L.; Pollice, A.; Hanreich, A.; Heyer, R.; Kausmann, R.; Heiermann, M. et al.; Klocke, M.; Rapp, E.; Reichl, U.: Metaproteomics for Process Monitoring in Environmental Biotechnology. Annual Conference of the Association for General and Applied Microbiology (VAAM), Bremen, Germany (2013)
  3. Fischer, L. M.; Kröber, T.; Wolff, M. W.; Reichl, U.: Purification of cell culture-derived influenza virus via continuous size exclusion chromatography. PREP- 26th International Symposium, Exhibit & Workshops on Preparative and Process Chromatography, Ion Exchange, Adsorption Processes & Related Separation Techniques, Boston, USA (2013)
  4. Fischer, L. M.: Purification of cell culture-derived influenza virus via continuous size exclusion chromatography. 3rd Workshop European Network on Viral Vaccine Processes (ENVVP), Frankfurt/Main (2013)
  5. Frensing, T.: Continuous cell culture-based influenza vaccine production. 3rd Workshop European Network on Viral Vaccine Processes (ENVVP), Frankfurt/Main (2013)
  6. Genzel, Y.; Behrendt, I.; Vogel, T.; Jordan, I.; Reichl, U.: Perfusion über das ATF System: Influenza Virusproduktion in Hochzelldichte. GVC/DECHEMA: Effiziente Verfahren und Anlagen in der Bioverfahrenstechnik und Lebensmittelbiotechnologie, Bad Wildungen, Germany (2013)
  7. Genzel, Y.; Reichl, U.: Metabolism as a key for improvement of cell culture processes-status and advances in analytics and data analysis. 23rd ESACT Meeting, Lille, France (2013)
  8. Genzel, Y.: New trends in vaccine research – high cell density cultivations. The 3rd National Biotechnology Conference 2013 - "Biotechnology for life", Ho Chi Minh City, Vietnam (2013)
  9. Genzel, Y.: Vaccine production in animal cell cultures. Fifth International School on Production of Biologicals using Animal Cell Cultures, Rio de Janeiro, Brasilien (2013)
  10. Heldt, S.; Isken, B.; Pflugmacher, A.; Frensing, T.; Reichl, U.: Multi-scale modeling of influenza virus infection elucidates the performance of antivirals. 1st Workshop on Virus Dynamics (DECHEMA), Frankfurt/Main, Germany (2013)
  11. Heldt, S.; Peschel, B.; Frensing, T.; Reichl, U.: Multiscale modeling of influenza virus infection supports the development of antiviral drugs. 14th International Conference on Systems Biology , Copenhagen (Denmark) (2013)
  12. Kottler, R.; Mank, M.; Stahl, B.; Reichl, U.; Rapp, E.: Fast Sample Preparation for "Real" High-Throughput Analysis of Human Milk Oligosaccarides Using xCGE-LIF. 7th Glycan Forum, Berlin, Germany (2013)
  13. Meininger, M.; Djurup, R.; Villain, L.; Cardosa, J.; Reichl, U.; Wolff, M. W.: Development of a Purification Strategy for Enterovirus 71 Like Particles for Vaccine Production. PREP- 26th International Symposium, Exhibit & Workshops on Preparative and Process Chromatography, Ion Exchange, Adsorption Processes & Related Separation Techniques, Boston, USA (2013)
  14. Meininger, M.; Santos da Silva, F. V.; Cajic, S.; Hennig, R.; Rapp, E.; Zwanziger, F.; Laufer, S.; Wiesmüller, K.-H.; Rotering, H.; Reichl, U. et al.; Wolff, M. W.: Development of a Sialic Acid-Specific Affinity Chromatography for the Purification and Separation of Glycoprotein Isoforms. ISPPP-International Symposium on the Separation of Proteins, Peptides & Polynucleotides, Boston, USA (2013)
  15. Meininger, M.; Djurup, R.; Villain, L.; Cardosa, J.; Reichl, U.; Wolff, M. W.: Development of a Purification Strategy for Enterovirus 71 Like Particles for Vaccine Production. 9th European Downstream Technology Forum , Göttingen, Germany (2013)
  16. Meininger, M.: Sialic Acid-Specific Chromatography for the Separation of Glycoforms. ÄKTA User Club , Weimar, Germany (2013)
  17. Meininger, M.: Purification of Enterovirus 71 Like Particles for Vaccin Production by the Use of Different Membrane Adsorbers. 3rd Workshop European Network on Viral Vaccine Processes (ENVVP), Frankfurt/Main (2013)
  18. Muth, T.; Hennig, R.; Behne, A.; Reichl, U.; Rapp, E.: glyXtool - a software tool for high-throughput processing of glycoanalysis data. 3. Beilstein-Symposium "Glyco-Bioinformatics", Potsdam, Germany (2013)
  19. Muth, T.: glyXtool – a software tool for high-throughput processing of glycoanalysis data. 24rd Joint Glycobiology Meeting, Wittenberg (2013)
  20. Rehberg, M.; Wetzel, M.; Genzel, Y.; Ritter, J.; Reichl, U.: The regulation of central carbon metabolism during adherent MDCK cell cultivation. 14th International Conference on Systems Biology (ICSB), Copenhagen, Denmark (2013)
  21. Rehberg, M.: The regulation of glutaminolysis and citric acid cycle activity during mammalian cell cultivation. Computer Applications in Bio Technology (CAB) 2013, Mumbai, Indien (2013)
 
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