Head of the Group

Prof. Dr.-Ing. Udo Reichl
Prof. Dr.-Ing. Udo Reichl
Phone: +49 391 6110 201
Fax: +49 391 6110 203

Contact Person

Annegret Frauendienst
Phone: +49 391 6110 200
Fax: +49 391 6110 203

Group Page

Publications

Publications BPE group

Journal Article (13)

  1. 2011
    Bock, A.; Schulze-Horsel, J.; Schwarzer, J.; Rapp, E.; Genzel, Y.; Reichl, U.: High-density microcarrier cell cultures for influenza virus production. Biotechnology Progress 27 (1), pp. 241 - 250 (2011)
  2. Frensing, T.; Seitz, C.; Heynisch, B.; Patzina, C.; Kochs, G.; Reichl, U.: Efficient influenza B virus propagation due to deficient interferon-induced antiviral activity in MDCK cells. Vaccine 29 (41), pp. 7125 - 7129 (2011)
  3. Janke, R.; Genzel, Y.; Händel, N.; Wahl, A.; Reichl, U.: Metabolic adaptation of MDCK cells to different growth conditions: Effects on catalytic activities of central metabolic enzymes. Biotechnology and Bioengineering 108 (11), pp. 2691 - 2704 (2011)
  4. Kalmbach, A.; Bordas, R.; Öncül, A.; Thévenin, D.; Genzel, Y.; Reichl, U.: Experimental Characterization of Flow Conditions in 2- and 20-L Bioreactors with Wave-Induced Motion. Biotechnology Progress 27 (2), pp. 402 - 409 (2011)
  5. Kolvenbach, B. A.; Lenz, M.; Benndorf, D.; Rapp, E.; Fousek, J.; Vlcek, C.; Schäffer, A.; Gabriel, F. L.; Kohler, H.-P. E.; Corvini, P. F.: Purification and characterization of hydroquinone dioxygenase from Sphingomonas sp. strain TTNP3. AMB Express 1, p. 8 (2011)
  6. Kuhn, R.; Benndorf, D.; Rapp, E.; Reichl, U.; Palese, L.; Pollice, A.: Metaproteome analysis of sewage sludge from membrane bioreactors. Proteomics 11 (13), pp. 2738 - 2744 (2011)
  7. Petiot, E.; Jacob, D.; Lanthier, S.; Lohr, V.; Ansorge, S.; Kamen, A. A.: Metabolic and Kinetic analyses of influenza production in perfusion HEK293 cell culture. BMC Biotechnology 11 (84), pp. 1 - 12 (2011)
  8. Popov, M.; Petrov, S. A.; Nacheva, G.; Ivanov, I.; Reichl, U.: Effects of a recombinant gene expression on ColE1-like plasmid segregation in Escherichia coli. BMC Biotechnology 11 (1), p. 18 (2011)
  9. Riedele, C.; Reichl, U.: Inter-Species Effects in Ceftazidime-Treated Mixed Culture of Pseudomonas aeruginosa, Burkholderia cepacia and Staphylococcus aureus – Analysis on the Single Species Level. Journal of Antimicrobial Chemotherapy 66 (1), pp. 138 - 145 (2011)
  10. Roedig, J.; Rapp, E.; Höper, D.; Genzel, Y.; Reichl, U.: Impact of Host Cell Line Adaptation on Quasispecies Composition and Glycosylation of Influenza A Virus Hemagglutinin. PLoS One 6 (12), p. e27989 (2011)
  11. Rödig, J.; Rapp, E.; Djeljadini, S.; Lohr, V.; Genzel, Y.; Jordan, I.; Sandig, V.; Reichl, U.: Impact of Influenza Virus Adaptation Status on HA N-Glycosylation Patterns in Cell Culture-Based Vaccine Production. Journal of Carbohydrate Chemistry 30 (4-6), pp. 281 - 290 (2011)
  12. Schmidt, J. K.; Riedele, C.; Regestein, L.; Rausenberger, J.; Reichl, U.: A novel concept combining experimental and mathematical analysis for the identification of unknown interspecies effects in a mixed culture. Biotechnology and Bioengineering 108 (8), pp. 1900 - 1911 (2011)
  13. Wolff, M.; Reichl, U.: Downstream processing of cell culture-derived virus particles. Expert Review of Vaccines 10 (10), pp. 1451 - 1475 (2011)

Conference Paper (1)

  1. Müller, T.; Dürr, R.; Isken, B.; Schulze-Horsel, J.; Reichl, U.; Kienle, A.: Population balance modelling of influenza virus replication during vaccine prodcution - Influence of apoptosis. In: 21st European Symposium on Computer Aided Process Engineering - Part A, pp. 1336 - 1340 (Eds. Pistikopoulos, E.N.; Georgiadis, M.C.; Kokossis, A.C.). ESCAPE 21 - 21st European Symposium on Computer Aided Process Engineering, Chalkidiki, Greece, May 29, 2011 - June 01, 2011. (2011)

Meeting Abstract (12)

  1. Barradas, O.P.; Jandt, U.; Phan, L.D.; Villanueva, M.; Rath, A.; Reichl, U.; Schräder, E.; Scholz, S.; Noll, T.; Sandig, V. et al.; Pörtner, R.; Zeng, A.P.: Criteria for bioreactor comparison and operation standardisation during process development for mammalian cell culture. In: BMC Proceedings, Vol. 5. 22nd European Society for Animal Cell Technology (ESACT) - Meeting on Cell Based Technologies , Vienna, Austria, May 15, 2011 - May 18, 2011. (2011)
  2. Borowiak, M.; Hennig, R.; Kottler, R.; Reichl, U.; Rapp, E.: Tailored methods for CGE-LIF based multiplexed high-throughput glycoanalysis with respect to sample characteristics. In: Glycoconjugate Journal, Vol. 28, p. 332. 21st International Symposium on Glycoconjugates - Glyco 21, Wien, Östereich, August 21, 2011 - August 26, 2011. (2011)
  3. Hennig, R.; Reichl, U.; Rapp, E.: A Software Tool for Automated High-Throughput Processing of CGE-LIF Based Glycoanalysis Data, Generated by a Multiplexing Capillary DNA Sequencer. In: Glycoconjugate Journal, Vol. 28, p. 331. 21st International Symposium on Glycoconjugates (Glyco 21), Wien, Östereich, August 21, 2011 - August 26, 2011. (2011)
  4. Hennig, R.; Borowiak, M.; Ruhaak, L. R.; Wuhrer, M.; Rapp, E.: High-Throughput CGE-LIF Based Analysis of APTS-labeled N-Glycans, Utilizing a Multiplex Capillary DNA Sequencer. In: Glycoconjugate Journal, Vol. 28, p. 331. 21st International Symposium on Glycoconjugates (Glyco 21), Wien, Östereich, August 21, 2011 - August 26, 2011. (2011)
  5. Hütter, J.; Rödig, J.; Reichl, U.; Seeberger, P. H.; Rapp, E.; Lepenies, B.: Impact of Influenza A virus hemagglutinin N-glycosylation on immunogenicity. In: Glycoconjugate Journal, Vol. 28, p. 305. 21st International Symposium on Glycoconjugates (Glyco 21), Wien, Östereich, August 21, 2011 - August 26, 2011. (2011)
  6. Janke, R.; Genzel, Y.; Wetzel, M.; Reichl, U.: Effect of influenza virus infection on key metabolic enzyme activities in MDCK cells. In: BMC Proceedings, Vol. 5. 22nd European Society for Animal Cell Technology (ESACT) - Meeting on Cell Based Technologies , Vienna, Austria, May 15, 2011 - May 18, 2011. (2011)
  7. Kolarich, D.; Rapp, E.; Packer, N.: Bioinformatics in Glycoproteomics – Challenges, Frontiers and Solutions. In: Glycoconjugate Journal, Vol. 28, p. 251. 21st International Symposium on Glycoconjugates (Glyco 21), Wien, Östereich, August 21, 2011 - August 26, 2011. (2011)
  8. Kottler, R.; Hennig, R.; Mank, M.; Stahl, B.; Reichl, U.; Rapp, E.: High-Throughput Characterization of the Human Milk Oligosaccharide Composition Utilizing a Multiplexing Capillary DNA Sequencer. In: Glycoconjugate Journal, Vol. 28, p. 330. 21st International Symposium on Glycoconjugates (Glyco 21), Wien, Östereich, August 21, 2011 - August 26, 2011. (2011)
  9. Rapp, E.; Hennig, R.; Borowiak, M.; Kottler, R.; Reichl, U.: High-Throughput Glycosylation Pattern Analysis of Glycoproteins Utilizing a Multiplexing Capillary-DNA-Sequencer. In: Glycoconjugate Journal, Vol. 28, p. 234. 21st International Symposium on Glycoconjugates - Glyco 21, Wien, Östereich, August 21, 2011 - August 26, 2011. (2011)
  10. Roedig, J.; Rapp, E.; Genzel, Y.; Reichl, U.: Impact of different influenza cultivation conditions on HA N-glycosylation. In: BMC Proceedings, Vol. 5. 22nd European Society for Animal Cell Technology (ESACT) Meeting on Cell Based Technologies , Vienna, Austria, May 15, 2011 - May 18, 2011. (2011)
  11. Scholz, S.; Luebbecke, M.; Rath, A.; Schraeder, E.; Rose, T.; Büntemeyer, H.; Scheper, T.; Reichl, U.; Noll, T.: Characterization of the human AGE1.HN cell line: a systems biology approach. In: BMC Proceedings, Vol. 5. 22nd European Society for Animal Cell Technology (ESACT) - Meeting on Cell Based Technologies , Vienna, Austria, May 15, 2011 - May 18, 2011. (2011)
  12. Schräder, E.; Scholz, S.; Niklas, J.; Rath, A.; Barradas, O.P.; Jandt, U.; Sandig, V.; Rose, T.; Pörtner, R.; Reichl, U. et al.; Zeng, A.P.; Heinzle, E.; Noll, T.: Characterisation of cultivation of the human cell line AGE1.HN.AAT. In: BMC Proceedings, Vol. 5, p. P87. 22nd European Society for Animal Cell Technology (ESACT) - Meeting on Cell Based Technologies , Vienna, Austria, May 15, 2011 - May 18, 2011. (2011)

Talk (18)

  1. Benndorf, D.; Heyer, R.; Kohrs, F.; Hanreich, A.; Klocke, M.; Rapp, E.; Reichl, U.: Gel-free metaproteome analysis of a biogas reactor. 1st International Conference on Biogas Microbiology, Leipzig, Germany (2011)
  2. Benndorf, D.; Kuhn, R.; Kohrs, F.; Palese, L. L.; Pollice, A.; Hanreich, A.; Heyer, R.; Klocke, M.; Rapp, E.; Reichl, U.: Metaproteome analysis in environmental biotechnology. First international symposium on microbial resource management in biotechnology: concepts & applications, Genth, Belgium (2011)
  3. Genzel, Y.; Reichl, U.: Evaluation of a new cell line for vaccine production. Fourth International School on Production of Biologicals in Animal Cell Cultures, Rio de Janeiro, Brazil (2011)
  4. Genzel, Y.; Reichl, U.: Vaccine production in animal cell cultures. Fourth International School on Production of Biologicals in Animal Cell Cultures, Rio de Janeiro, Brazil (2011)
  5. Genzel, Y.; Janke, R.; Isken, B.; Rödig, J.; Rapp, E.; Lohr, V.; Behrendt, I.; Scharfenberg, K.; Kamen, A.; Schiedner, G. et al.; Jordan, I.; Reichl, U.: Influenza virus production: characteristics of different producer cell lines. 10th PEACe 2011, Cascais, Portugal (2011)
  6. Heldt, F. S.; Reichl, U.: Understanding the dynamics of intracellular virus replication - How does Influenza control its RNA and protein synthesis? 4th ESWI Influenza Conference, Malta (2011)
  7. Heynisch, B.; Frensing, T.; Seitz, C.; Genzel, Y.; Reichl, U.: Analysis of the impact of innate immunity of MDCK cells on virus replication in influenza vaccine production. ECAB 2011, Berlin (2011)
  8. Janke, R.; Genzel, Y.; Wahl, A.; Reichl, U.: Recombinant glycerokinase from Pichia farinosa: Intracellular expression, purification, characterization, and application. 1st European Congress of Applied Biotechnology, Berlin, Germany (2011)
  9. Kluge, S.; Hoffmann, M.; Benndorf, D.; Rapp, E.; Reichl, U.: Proteomic Tracking - Populationsdynamik und Interaktion einer bakteriellen Mischkultur. 18. Arbeitstagung - Mikromethoden der Proteinchemie, Martinsried, Germany (2011)
  10. Rapp, E.; Kluge, S.; Hoffmann, M.; Benndorf, D.; Reichl, U.: Proteomic Tracing: Population Dynamics and Species Interaction of a Mucoviscidosis Relevant Bacterial Mixed Culture. PROTEOMICS 2.0 Initiative - Seminartour 2011 - Station Magdeburg, Universitätsklinikum, Magdeburg, Germany (2011)
  11. Rapp, E.; Hennig, R.; Borowiak, M.; Kottler, R.; Reichl, U.: High-Throughput Glycosylation Pattern Analysis of Glycoproteins Utilizing a Multiplexing Capillary-DNA-Sequencer. 16th European Carbohydrate Symposium (Eurocarb 16), Sorrento - Naples, Italy (2011)
  12. Rapp, E.; Hennig, R.; Borowiak, M.; Kottler, R.; Reichl, U.: Tools for the Glycome Analysis in the Post-Genomic Era. 7th ISABS Conference in Forensic, Anthropologic and Medical Genetics and Mayo Clinic Lectures in Translational Medicine, Bol, Island of Brač, Croatia (2011)
  13. Rapp, E.; Hennig, R.; Rödig, J.; Borowiak, M.; Kottler, R.; Reichl, U.: High-Throughput Glycosylation Pattern Analysis of Glycoproteins (Utilizing a Multiplexing Capillary-DNA-Sequencer). DECHEMA Frühjahrssitzung Biotechnologie, Dechemahaus, Frankfurt, Germany (2011)
  14. Reichl, U.: Influenza virus production in mammalian cell culture. CeBiTec Distinguished Lecture, Bielefeld, Germany (2011)
  15. Reichl, U.: On the complexity of virus-host cell interaction: Dynamics of Influenza A Virus Replication in Mammalian Cell Culture. 11th International Chemical and Biological Engineering Conference: CHEMPOR 2011, Lisbon, Portugal (2011)
  16. Reichl, U.: Dynamics of Influenza A Virus Replication in Mammalian Cell Culture. BBBC Congress, Edinburgh, Scotland (2011)
  17. Reichl, U.: Comparison of Cell Lines Considered for Influenza A virus Manufacturing. 22nd European Society for Animal Cell Technology: ESACT-Meeting on Cell Based Technologies, Vienna, Austria (2011)
  18. Rüger, M.; Siewert, C.; Kluge, S.; Hoffmann, M.; Benndorf, D.; Rapp, E.; Reichl, U.: Flow cytometric monitoring of a three-species mixed bacterial community relevant for Cystic Fibrosis. 5th Conference Analysis of Microbial Cells at Single Cell Level, Carry le Rouet, France (2011)

Poster (26)

  1. Borowiak, M.; Hennig, R.; Reichl, U.; Rapp, E.: Improved sample preparation for CGE-LIF based automated high-throughput glycoanalysis using a standard DNA sequencer. 5th Glycan Forum, Berlin, Germany (2011)
  2. Castro, R.; Genzel, Y.; Scharfenberg, K.; Kremer, E.J.; Alves, P.M.; Coroadinha, A.S.: Production of Canine Adenovirus Vectors in Serum-free Suspension Cultures of Madine Darby Canine Kidney Cells. 22nd ESACT Meeting, Vienna, Austria (2011)
  3. Frensing, T.; Seitz, C.; Isken, B.; Heynisch, B.; Kochs, C.; Reichl, U.: Influence of Host Cell Defence during Influenza Vaccine Production in Cell Culture. 22nd ESACT Meeting, Vienna, Austria (2011)
  4. Frensing, T.; Seitz, C.; Isken, B.; Heynisch, B.; Kochs, C.; Reichl, U.: Influence of Host Cell Defence during Influenza Vaccine Production in Cell Culture. 22nd ESACT Meeting, Vienna, Austria (2011)
  5. Freund, S.; Rath, A.; Sandig, V.; Rose, T.; Reichl, U.: AGE1.HN.AAT - growth of a human cell line in glucose excess and limitation: comparison of different metabolic states via stationary metabolic flux analysis. 22nd ESACT Meeting, Vienna, Austria (2011)
  6. Heldt, F. S.; Frensing, T.; Reichl, U.: Mechanistic model of influenza virus replication elucidates the intracellular dynamics and control of viral RNA synthesis. 12th International Conference on Systems Biology, Heidelberg/Mannheim, Germany (2011)
 
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