Head of the Group

Prof. Dr.-Ing. Udo Reichl
Prof. Dr.-Ing. Udo Reichl
Phone: +49 391 6110 201
Fax: +49 391 6110 203

Contact Person

Annegret Frauendienst
Phone: +49 391 6110 200
Fax: +49 391 6110 203

Group Page

Publications

Publications BPE group

Journal Article (9)

  1. 2009
    Bock, A.; Möhler, L.; Sann, H.; Schulze-Horsel, J.; Genzel, Y.; Reichl, U.: Growth behaviour of number distributed adherent MDCK cells for optimization in large scale microcarrier cultures. Biotechnology Progress 25 (6), pp. 1717 - 1731 (2009)
  2. Genzel, Y.; Reichl, U.: Continuous cell lines as production system for influenza vaccines. Expert Review of Vaccines 8 (12), pp. 1681 - 1692 (2009)
  3. Lohr, V.; Rath, A.; Genzel, Y.; Jordan, I.; Sandig, V.; Reichl, U.: New avian suspension cell lines provide production of influenza virus and MVA in serum-free media: studies on growth, metabolism and virus propagation. Vaccine 27 (36), pp. 4975 - 4982 (2009)
  4. Opitz, L.; Lehmann, S.; Reichl, U.; Wolff, M. W.: Sulfated membrane adsorbers for economic pseudo-affinity capture of influenza virus particles. Biotechnology and Bioengineering 103 (6), pp. 1144 - 1154 (2009)
  5. Opitz, L.; Hohlweg, J.; Reichl, U.; Wolff, M. W.: Purification of cell culture-derived influenza virus A/Puerto Rico/8/34 by membrane-based immobilized metal affinity chromatography. Journal of Virological Methods 161 (2), pp. 312 - 316 (2009)
  6. Rapp, E.; Charvat, A.; Beinsen, A.; Plessmann, U.; Reichl, U.; Seidel-Morgenstern, A.; Urlaub, H.; Abel, B.: Atmospheric Pressure Free Liquid Infrared MALDI Mass Spectrometry: Toward a combined ESI/MALDI-Liquid Chromatography Interface. Analytical Chemistry 81 (1), pp. 443 - 452 (2009)
  7. Schulze-Horsel, J.; Schulze, M.; Agalaridis, G.; Genzel, Y.; Reichl, U.: Infection dynamics and virus-induced apoptosis in cell culture-based influenza vaccine production – flow cytometry and mathematical modeling. Vaccine 27 (20), pp. 2712 - 2722 (2009)
  8. Schwarzer, J.; Rapp, E.; Hennig, R.; Genzel, Y.; Jordan, I.; Sandig, V.; Reichl, U.: Glycan analysis in cell culture-based influenza vaccine production: Influence of host cell line and virus strain on the glycosylation pattern of viral hemagglutinin. Vaccine 27 (32), pp. 4325 - 4336 (2009)
  9. Vester, D.; Rapp, E.; Gade, D.; Genzel, Y.; Reichl, U.: Quantitative analysis of cellular proteome alterations in human influenza A virus-infected mammalian cell lines. Proteomics 9 (12), pp. 3316 - 3327 (2009)

Meeting Abstract (1)

  1. Öncül, A.; Kalmbach, A.; Genzel, Y.; Reichl, U.; Thevenin, D.: Numerische und experimentelle Untersuchung der Fließbedingungen in Wave-Bioreaktoren. In: Chemie-Ingenieur-Technik, Vol. 81, p. 1241 . ProcessNet-Jahrestagung 2009 und 27. Jahrestagung der Biotechnologen, Mannheim, Germany, September 08, 2009 - September 10, 2009. Verlag Chemie, GmbH, Weinheim, Germany (2009)

Talk (22)

  1. Janke, R.; Genzel, Y.; Wahl, A.; Reichl, U.: Influence of cell culture medium on the catalytic activity of key enzymes in MDCK cells. 27. Jahrestagung der Biotechnologen, Mannheim, Germany (2009)
  2. Kröber, T.; Wolff, M.; Hundt, B.; Reichl, U.; Seidel-Morgenstern, A.: Purification of Cell Culture-Derived Influenza Virus using Continuous Simulated Moving Bed Chromatography. ISPPP 2011, Alexandria, USA (2009)
  3. Lohr, V.; Genzel, Y.; Jordan, I.; Sandig, V.; Reichl, U.: Stoffwechsel und Zellphysiologie aviärer Designerzellen während Wachstum und MVA-Produktion. ProcessNet-Jahrestagung 2009 und 27. Jahrestagung der Biotechnologen, Mannheim, Germany (2009)
  4. Lohr, V.; Rath, A.; Jordan, I.; Sandig, V.; Genzel, Y.; Reichl, U.: Avian designer cells AGE1.CR: possible candidates for MVA and influenza vaccine production? 21st ESACT Meeting, Dublin, Ireland (2009)
  5. Opitz, L.; Lehmann, S.; Zimmermann, A.; Hohlweg, J.; Reichl, U.; Wolff, M. W.: Affinity capture of cell culture-derived influenza virus particles. Prep 2009, Philadelphia, USA (2009)
  6. Rapp, E.; Schwarzer, J.; Hennig, R.; Roedig, J.; Reichl, U.: Towards High Throughput Characterization of Glycosylation-Patterns Using a Capillary-DNA-Sequencer. CE in Biotechnology & Pharmaceutical Industries: 11th Symposium on the Practical Applications for the Analysis of Proteins, Nucleotides and Small Molecules (CE Pharm 2009), Boston, MA, USA (2009)
  7. Rapp, E.: Towards high-throughput characterization of carbohydrates using a capillary-DNA-sequencer. Post-Translational Modifications, Prague, Czech Republic (2009)
  8. Rapp, E.; Charvat, A.; Beinsen, A.; Reichl, U.; Seidel-Morgenstern, A.; Urlaub, H.; Abel, B.: The Atmospheric Pressure Free Liquid Infrared Matrix Assisted Laser Dispersion Ionisation – A New LC-MS Interface. 18th International Mass Spectrometry Conference, Bremen, Germany (2009)
  9. Rapp, E.; Schwarzer, J.; Hennig, R.; Genzel, Y.; Reichl, U.: Glycan-analysis in influenza vaccine production based on cgelif: influence of host cell and virus on the glycosylationpattern of viral hemagglutinin. EUROCARB 2009 (15th European Carbohydrate Symposium), Main University Vienna, Austria (2009)
  10. Rapp, E.; Charvát, A.; Beinsen, A.; Urlaub, H.; Plessmann, U.; Reichl, U.; Seidel-Morgenstern, A.; Abel, B.: Unifying LC-MS Interfaces: The Atmospheric Pressure Free Liquid Infrared Matrix Assisted Laser Dispersion Ionisation. 42. DGMS Jahrestagung, Konstsanz, Germany (2009)
  11. Rapp, E.: Workflow Optimierung zur Durchsatzsteigerung der CGE-LIF basierten Glykan-Analytik. Meeting with Merck-Serono, Darmstadt, Germany (2009)
  12. Rapp, E.: Utilizing Capillary Gel Electrophoresis with Laser Induced Fluorescence Detection for Glycan-Fingerprinting of Viral Glycoproteins. Wissenschaftliches Kolloqium an der Charite, Berlin, Germany (2009)
  13. Reichl, U.: Zellkulture - eine Übersicht. Deutscher Influenza Kongress, Erfurt, Germany (2009)
  14. Reichl, U.: Dynamics of Influenza Virus replication in Mammalian Cell Culture. Workshop Molecular Interactions, Berlin, Germany (2009)
  15. Reichl, U.: Dynamics of Influenza Virus Replication and Apotosis in Mammalian Cell Culture Flow Cytometry and Mathematical Modeling. Biochemical Engineering XVI - Past, Present and Future of Biochemical Engineering, Burlington, Canada (2009)
  16. Reichl, U.: Cell Culture Technology - A New Standard for Influenza Vaccine. 26th International Congress of Chemotherapy, Toronto, Canada (2009)
  17. Reichl, U.: A Systemsa Perspective of Virus Replication in Mammalian Cell Cultures. Biotechnologisches Kolloquium, Saarbrücken, Germany (2009)
  18. Reichl, U.: Virus Dynamics in Mammalian Cell Culture. Thematic School of the Epigenomics Project entitled "Modelling of complex biological systems in the context of genomics, Nizza, Italy (2009)
  19. Wolff, M.; Opitz, L.; Siewert, C.; Petermann, N.; Meininger, M.; Lehmann, S.; Hansen, S.P.; Faber, R.; Reichl, U.: Capture of cell culture-derived virus particles by affinity membrane adsorbers. Vaccines Europe, Brussels, Belgium (2009)
  20. Wolff, M.; Opitz, L.; Siewert, C.; Petermann, N.; Meininger, M.; Lehmann, S.; Hansen, S.P.; Faber, R.; Reichl, U.: Membrane adsorbers to capture cell culture derived virus particles. 29th International Symposium & Exhibit on the Separation of Proteins, Peptides and Polynucleotides, Delray Beach, Florida, USA (2009)
  21. Öncül, A.; Genzel, Y.; Reichl, U.; Thevenin, D.: Investigation of oxygen transfer process in wave bioreactors using Computational Fluid Dynamics. 5th International Berlin Workshop – IBW5, Berlin, Germany (2009)
  22. Öncül, A.; Thevenin, D.; Kalmbach, A.; Genzel, Y.; Reichl, U.: Numerical and experimental investigation of flow conditions in wave bioreactors. ProcessNet-Jahrestagung 2009 und 27. Jahrestagung der Biotechnologen, Mannheim, Germany (2009)

Poster (30)

  1. Freund, S.; Sandig, V.; Rose, T.; Reichl, U.: Characterization of batch cultivations of a new human suspension cell line. BioSys2009, Hamburg (2009)
  2. Genzel, Y.; Behrendt, I.; Scharfenberg, K.; Reichl, U.: Evaluation of a new suspension MDCK cell line for influenza vaccine production. 21st ESACT Meeting, Dublin, Ireland (2009)
  3. Heynisch, B.; Seitz, C.; Frensing, T.; Genzel, Y.; Reichl, U.: Virus-host cell interactions in a bioprocess for influenza vaccine production - characterization of antiviral signaling pathways. ProcessNet-Jahrestagung 2009 und die 27.Jahrestagung der Biotechnologen , Mannheim, Germany (2009)
  4. Heynisch, B.; Seitz, C.; Frensing, T.; Genzel, Y.; Reichl, U.: Analysis of antiviral signaling cascades in a bioprocess for influenza vaccine production. 21st ESACT Meeting, Dublin, Ireland (2009)
  5. Heynisch, B.; Seitz, C.; Frensing, T.; Genzel, G.; Reichl, U.: Systems biology of influenza virus-host cell interaction in a bioprocess for vaccine production. German Symposium on Systems Biology 2009, Heidelberg, Germany (2009)
  6. Heynisch, B.; Schulze-Horsel, J.; Frensing, T.; Genzel, Y.; Reichl, U.: Analysis of Signaling Cascades and Host Cell Defense in a Bioprocess for Influenza Vaccine Production. 19th Annual Meeting of the German Society for Virology 2009, Leipzig, Germany (2009)
  7. Janke, R.; Genzel, Y.; Wahl, A.; Reichl, U.: Catalytic activity changes of key enzymes in MDCK cells under different growth conditions. 21st ESACT Meeting, Dublin, Ireland (2009)
  8. Janke, R.; Genzel, Y.; Wahl, A.; Reichl, U.: A high-throughput platform to measure key enzyme activities in mammalian cells. German Symposium on Systems Biology, Heidelberg, Germany (2009)
  9. Kremling, A.; Janke, R.; Genzel, Y.; Wahl, A.; Reichl, U.: WPT7: Model Validation, Parameter Analysis and Experimental Design. Part I: Parameter estimation and parameter confidence intervalls. Part II: Key enzyme activities in central carbon metabolism of mammalian cells. Evaluation and Status Seminar FORSYS 2009, Heidelberg, Germany (2009)
  10. Kröber, T.; Wolff, M.; Hebel, K.; Brunner-Weinzierl, M.; Reichl, U.: Particulate Formulation of Influenza Virus Antigen in the Form of ISCOMs. ISPPP 2009, Delray Beach, Florida, USA (2009)
  11. Kröber, T.; Wolff, M. W.; Lehmann, S.; Zimmermann, A.; Reichl, U.: Accounting for the Entire Influenza Hemagglutinin During a Flu Vaccine Production Process. 21st ESACT Meeting, Dublin, Ireland (2009)
  12. Lagoda, A.; Hoffmann, D.; Vester, D.; Bettenbrock, K.; Genzel, Y.; Reichl, U.: Realtime-PCR-assay for the quantitative analysis of human influenza A virus replication: validation of an assay for vRNA, cRNA \& mRNA polarity specific primers. Dechema 2009 Event, Mannheim, Germany (2009)
  13. Lohr, V.; Genzel, Y.; Jordan, I.; Sandig, V.; Reichl, U.: Characterization of avian designer cells as substrates for MVA production. 21st ESACT Meeting, Dublin, Ireland (2009)
  14. Medger, A.; Miehe, K.; Bettenbrock, K.: Investigation of the Escherichia coli lac operon on population and on single cell level. FEMS Meeting 2009, Götheburg, Schweden (2009)
  15. Medger, A.; Miehe, K.; Bettenbrock, K.: Investigations of the Escherichia coli lac operon. German Symposium on Systems Biology, Heidelberg, Germany (2009)
  16. Rath, A.; Genzel, Y.; Sandig, V.; Rose, T.; Reichl, U.: Strategies For Batch Cultivation Of Two New Human Suspension Cell Lines: Culture Conditions And Cellular Metabolism. BioSys2009, Hamburg, Germany (2009)
  17. Rath, A.; Genzel, Y.; Sandig, V.; Rose, T.; Reichl, U.: A Novel Human Designer Cell Line: Metabolism During Cell Growth. ProcessNet-Jahrestagung 2009 und 27. Jahrestagung der Biotechnologen, Mannheim, Germany (2009)
  18. Rath, A.; Genzel, Y.; Sandig, V.; Rose, T.; Reichl, U.: Cell Growth and Metabolism of a Novel Human Designer Cell Line. 21st ESACT Meeting, Dublin, Ireland (2009)
 
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