Head of the Group

Prof. Dr.-Ing. Udo Reichl
Prof. Dr.-Ing. Udo Reichl
Phone: +49 391 6110 201
Fax: +49 391 6110 203

Contact Person

Annegret Frauendienst
Phone: +49 391 6110 200
Fax: +49 391 6110 203

Group Page

Publications

Publications BPE group

Journal Article (10)

  1. 2007
    Bandaru, K. S.V.S.R.; Keßler, L. C.; Wolff, M. W.; Reichl, U.; Seidel-Morgenstern, A.; Pushpavanam, S.: Hydrodynamic characteristics and expansion behavior of beds containing single and binary-mixtures of particles. Industrial and Engineering Chemistry Research 46 (13), pp. 4686 - 4694 (2007)
  2. Hundt, B.; Best, C.; Schlawin, N.; Kassner, H.; Genzel, Y.; Reichl, U.: Establishment of a mink enteritis vaccine production process in stirred-tank reactor and Wave Bioreactor microcarrier culture in 1-10 L scale. Vaccine 25 (20), pp. 3987 - 3995 (2007)
  3. Kalbfuss, B.; Genzel, Y.; Wolff, M. W.; Zimmermann, A.; Morenweiser, R.; Reichl, U.: Harvesting and concentration of human influenza A virus produced in serum-free mammalian cell culture for the production of vaccines. Biotechnology and Bioengineering 97 (1), pp. 73 - 85 (2007)
  4. Kalbfuss, B.; Wolff, M. W.; Morenweiser, R.; Reichl, U.: Purification of cell culture-derived human influenza A virus by size-exclusion and anion-exchange chromatography. Biotechnology and Bioengineering 96, pp. 932 - 944 (2007)
  5. Kalbfuss, B.; Wolff, M. W.; Geisler, L.; Tappe, A.; Wickramasinghe, R.; Thom, V.; Reichl, U.: Direct capture of influenza A virus from cell culture supernatant with Sartobind anion-exchange membrane adsorbers. Journal of Membrane Science 299, pp. 251 - 260 (2007)
  6. Nischang, I.; Reichl, U.; Seidel-Morgenstern, A.; Tallarek, U.: Concentration Polarization and Nonequilibrium Electroosmotic Slip in Dense Multiparticle Systems. Langmuir 23 (18), pp. 9271 - 9281 (2007)
  7. Noack, S.; Wahl, A.; Qeli, E.; Wiechert, W.: Visualizing Regulatory Interactions in Metabolic Networks. BMC Biology 5, p. 46 (2007)
  8. Opitz, L.; Salaklang, J.; Büttner, H.; Reichl, U.; Wolff, M. W.: Lectin-affinity chromatography for downstream processing of MDCK cell culture derived human influenza A viruses. Vaccine 25 (5), pp. 939 - 947 (2007)
  9. Opitz, L.; Lehmann, S.; Zimmermann, A.; Reichl, U.; Wolff, M. W.: Impact of adsorbents selection on affinity purification efficiency of cell culture derived human Influenza viruses. Journal of Biotechnology 131 (3), pp. 309 - 317 (2007)
  10. Pohlscheidt, M.; Langer, U.; Minuth, T.; Bödeker, B.; Apeler, H.; Hörlein, H. D.; Paulsen, D.; Rübsamen-Waigmann, H.; Henzler, H. J.; Reichl, U.: Development and optimisation of a procedure for the production of Parapoxvirus Ovis by large scale microcarrier cell culture in a non animal, non human and non plant derived medium. Vaccine 26 (12), pp. 1552 - 1565 (2007)

Book Chapter (3)

  1. Genzel, Y.; Reichl, U.: Vaccine production - state of the art and future needs in upstream processing. In: Animal Cell Biotechnology: Methods and Protocols, pp. 457 - 473 (Ed. Pörtner, R.). HUMANA Press Inc., Totowa, New Jersey (2007)
  2. Reichl, U.; Sidorenko, Y.: Dynamics of Virus-Host Cell Interaction. In: Bioinformatics: From Genomes to Therapies, pp. 861 - 898 (Ed. Lengauer, T.). Wiley-VCH, Weinheim (2007)
  3. Ritter, J. B.; Genzel, Y.; Reichl, U.: Monitoring of Extracellular TCA Cycle Intermediates in Mammalian Cell Culture. In: Cell Technology for Cell Products: Proceedings of the 19th ESACT Meeting, pp. 603 - 605 (Ed. Smith, R.). Springer, Dordrecht, The Netherlands (2007)

Conference Paper (7)

  1. Bock, A.; Reichl, U.: Closed loop control of perfusion systems in high-density cell culture. In: Cell Technology for Cell Products: Proceedings of the 19th ESACT Meeting, pp. 549 - 551 (Ed. Smith, R.). 19th ESACT Meeting, Harrogate, UK, June 05, 2005 - June 08, 2005. Springer, Dordrecht, The Netherlands (2007)
  2. Genzel, Y.; Fischer, M.; Olmer, R. M.; Schäfer, B.; Best, C.; König, S.; Hundt, B.; Reichl, U.: Serum-free influenza vaccine production with MDCK cells in wave-bioreactor and 5L-stirred tank bioreactor. In: Cell Technology for Cell Products: Proceedings of the 19th ESACT Meeting, pp. 563 - 565 (Ed. Smith, R.). 19th ESACT Meeting , Harrogate, UK, June 05, 2005 - June 08, 2005. Springer, Dordrecht, The Netherlands (2007)
  3. Genzel, Y.; Schulze-Horsel, J.; Möhler, L.; Sidorenko, Y.; Reichl, U.: Influenza Vaccines: Challenges in Mammalian Cell Culture Technology. In: Cell Technology for Cell Products: Proceedings of the 19th ESACT Meeting, pp. 503 - 508 (Ed. Smith, R.). 19th ESACT Meeting, Harrogate, UK, June 05, 2005 - June 08, 2005. Springer, Dordrecht, The Netherlands (2007)
  4. Hundt, B.; Straube, S.; Schlawin, N.; Kaßner, H.; Reichl, U.: Cultivation of E-FL in Perfusion Mode Using Wave Bioreactor and Stirre-Tank Reactor for Parvovirus Vaccine Production. In: Cell Technology for Cell Products: Proceedings of the 19th ESACT Meeting, pp. 519 - 522 (Ed. Smith, R.). 19th ESACT Meeting, Harrogate, UK, June 05, 2005 - June 08, 2005. Springer, Dordrecht, The Netherlands (2007)
  5. Pohlscheidt, M.; Langer, U.; Bödeker, B.; Paulsen, D.; Rübsamen-Waigmann, H.; Reichl, U.; Henzler, H. J.; Apeler, H.: Strategies for Large Scale Production of Parapoxvirus Ovis NZ-2. In: Cell Technology for Cell Products: Proceedings of the 19th ESACT Meeting, pp. 707 - 710 (Ed. Smith, R.). 19th ESACT Meeting, Harrogate, UK, June 05, 2005 - August 06, 2005. Springer, Dordrecht, The Netherlands (2007)
  6. Reichl, U.: Biological Fundamentals, Models and Technologies for Vaccine Production. In: Perspectives of Research - Identification and Implementation of Research Topics by Organizations: Ringberg-Symposium Mai 2006, Vol. 7, pp. 191 - 208. Ringberg-Symposium, Kreuth, Germany, May 03, 2006 - May 05, 2006. (2007)
  7. Schulze-Horsel, J.; Genzel, Y.; Reichl, U.: Monitoring of Cell Physiology in Influenza Vaccine Production by Flow Cytometry. In: Cell Technology for Cell Products: Proceedings of the 19th ESACT Meeting, pp. 531 - 533 (Ed. Smith, R.). 19th ESACT Meeting, Harrogate, UK, June 05, 2005 - August 06, 2005. Springer, Dordrecht, The Netherlands (2007)

Meeting Abstract (1)

  1. Noack, S.; Wahl, A.; Oldiges, M.; Wiechert, W.: Visualizing regulatory interactions in metabolic networks. In: BMC Systems Biology, Vol. 1, p. 5. BioSysBio 2007 : Systems Biology, Bioinformatics and Synthetic Biology, Manchester, UK, January 11, 2007 - January 13, 2007. (2007)

Talk (22)

  1. Dietzsch, C.; Genzel, Y.; Reichl, U.: Vero or MDCK cells for influenza A virus production in microcarrier systems? European BioPerspectives 2007, Cologne, Germany (2007)
  2. Genzel, Y.; Bock, A.; Schwarzer, J.; Dietzsch, C.; Reichl, U.: Implementation of analytical methods during upstream processing for an influenza A virus production process. Vaccine Production : Analytical Methods, Characterisation, Scale-up and Manufacturing, Cologne, Germany (2007)
  3. Opitz, L.; Zimmermann, A.; Lehmann, S.; Genzel, Y.; Lübben, H.; Reichl, U.; Wolff, M. W.: Efficient influenza virus capture from cell cultivation broth by a novel affinity chromatography. AIChE Annual meeting 2007, Salt Lake City, USA (2007)
  4. Opitz, L.; Zimmermann, A.; Lehmann, S.; Genzel, Y.; Lübben, H.; Reichl, U.; Wolff, M. W.: Novel capturing method for currently spread influenza viruses from cell cultures by affinity separation. ISPPP 2007, Orlando, USA (2007)
  5. Opitz, L.; Zimmermann, A.; Genzel, Y.; Lübben, H.; Reichl, U.; Wolff, M. W.: Lectin-affinity chromatography: a novel purification method for cell culture based Influenza vaccine production from the current season 2006/07. European BioPerspectives 2007, Cologne, Germany (2007)
  6. Opitz, L.; Zimmermann, A.; Genzel, Y.; Lübben, H.; Reichl, U.; Wolff, M. W.: Lektin-Affinitätschromatographie - Neuartige Methode zur Aufreinigung humaner Influenza Viren aus Zellkulturen zur Impfstoffproduktion. DECHEMA/GVC Vortrag- und Diskussionstagung "Aufarbeitung biotechnologischer Produkte", Osnabrück, Germany (2007)
  7. Rapp, E.; Vester, D.; Genzel, Y.; Gade, D.; Reichl, U.: Quantitative proteomic analysis of influenza A virus infected mammalian cells: Elucidation of virus / host cell interactions with respect to the vaccine production process. 27th International Symposium & Exhibit on the Separation of Proteins, Peptides & Polynucleotides (ISPPP 2007), Orlando, USA (2007)
  8. Rapp, E.; Schwarzer, J.; Reichl, U.: Characterisation of Glycosylation Patterns Utilizing a DNA-Sequenzer and Mass Spectrometry. 14th European Carbohydrate Symposium, Lübeck, Germany (2007)
  9. Rapp, E.; Schwarzer, J.; Reichl, U.: Characterisation of Glycosylation Patterns Utilizing a DNA-Sequenzer and a MALDI-TOF Mass Spectrometer. 7th Carbohydrate Bioengineering Meeting (CBM7), Braunschweig, Germany (2007)
  10. Rapp, E.; Schwarzer, J.; Reichl, U.: Elucidation of the Influenza A Virus Glycosylation Patterns with Respect to Vaccine Production Down to the Lower Zeptomolar Range. 21st International Symposium on MicroScale Bioseparations (MSB), Vancouver, BC, Canada (2007)
  11. Reichl, U.: A Systems Perspective of Virus Replication in Mammalian Cell Cultures. Meeting at MPI Golm, Potsdam-Golm, Germany (2007)
  12. Reichl, U.: Influenza Vaccines: Challenges in Optimization of Virus Yields in Mammalian Cell Culture. Vaccine Congress, Amsterdam, The Netherlands (2007)
  13. Reichl, U.: Characterization of Cell Growth and Influenza Virus Replication in Microcarrier Culture. Kooperationsgespräch bei ROCHE AG, Penzberg, Germany (2007)
  14. Reichl, U.: A Systems Perspective of Influenza Virus Replication in Cell Cultures. European Conference on Complex Systems, Dresden, Germany (2007)
  15. Reichl, U.: Theoretical and Experimental Characterization of Influenza Virus Replication in Cell Cultures. Meeting Helmholtz-Zentrum, Braunschweig, Germany (2007)
  16. Reichl, U.: Theoretical and Experimental Characterization of Influenza Virus Replication in Cell Cultures. DECHEMA-Arbeitsausschuss Biotechnologie, Frankfurt/M., Germany (2007)
  17. Reichl, U.: Mathematical Modeling of Mammalian Cell Cultures - Cell Growth and Product Synthesis. MPG-CNRS Treffen, Paris, France (2007)
  18. Reichl, U.: MDCK cell derived influenza vaccines - aspects of up- and downstream processing. Meeting Merck & Co., Inc., USA (2007)
  19. Reichl, U.: Mathematical Modeling of Mammalian Cell Cultures: From Cell Populations to Individual Cells. Workshop "Systems biology", Leipzig, Germany (2007)
  20. Ritter, J. B.; Genzel, Y.; Reichl, U.: Metabolite Analysis in Mammalian Cells: How to generate reliable data sets? 20th ESACT meeting, Dresden, Germany (2007)
  21. Schmidt, J. K.; Riedele, C.; Regestein, L.; Geisler, L.; Reichl, U.: A Medically Relevant Three-Species Mixed Culture in a Chemostat: Mathematical Modelling and Experiments to Study Interaction Effects. European BioPerspectives 2007, Cologne, Germany (2007)
  22. Schwarzer, J.; Rapp, E.; Reichl, U.: N-glycan analysis method for cell culture derived influenza virus hemagglutinin. Joint Meeting 2007, Lille, France (2007)

Poster (24)

  1. Bock, A.; Genzel, Y.; Reichl, U.: Higher yields in influenza vaccine production using perfusion in high-density cell culture. Vaccine Congress, Amsterdam, The Netherlands (2007)
  2. Bock, A.; Genzel, Y.; Reichl, U.: Monitoring of cell activity: online oxygen uptake rates in pulsed aerated cell culture. 20th ESACT Meeting, Dresden, Germany (2007)
  3. Bock, A.; Reichl, U.: Online measurement and balancing of dissolved carbon dioxide in cell culture technology. European BioPerspectives, Cologne, Germany (2007)
  4. Genzel, Y.; Vester, D.; Schulze-Horsel, J.; Bock, A.; Reichl, U.: Analytical platform for bioprocesses with adherent mammalian cells. MPG-CNRS Joint Workshop on Systems Biology, Berlin, Germany (2007)
  5. Genzel, Y.; Dietzsch, C.; Reichl, U.: Comparing Vero and MDCK cells for influenza A virus production in microcarrier systems. 20th ESACT Meeting , Dresden, Germany (2007)
  6. Opitz, L.; Zimmermann, A.; Genzel, Y.; Lübben, H.; Reichl, U.; Wolff, M. W.: Lectin-affinity chromatography for downstream processing of current influenza virus strains from MDCK and Vero cell cultivations. AIChE Annual meeting 2007, Salt Lake City, USA (2007)
  7. Rapp, E.; Schwarzer, J.; Reichl, U.: Elucidation of the Influenza A Virus Glycosylation-Patterns with Respect to Vaccine-Production Down to the Zeptomolar Range. 3rd Glycan Forum Berlin 2007, Berlin-Dahlem, Germany (2007)
 
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