Head of the Group

Prof. Dr.-Ing. Udo Reichl
Prof. Dr.-Ing. Udo Reichl
Phone: +49 391 6110 201
Fax: +49 391 6110 203

Contact Person

Annegret Frauendienst
Phone: +49 391 6110 200
Fax: +49 391 6110 203

Group Page

Publications

Publications BPE group

Journal Article (7)

  1. 2006
    Antoniukas, L.; Grammel, H.; Reichl, U.: Production of hantavirus Puumala nucleocapsid protein in Saccharomyces cerevisiae for vaccine and diagnostics. Journal of Biotechnology 124 (2), pp. 347 - 362 (2006)
  2. Genzel, Y.; Fischer, M.; Reichl, U.: Serum-free influenza virus production avoiding washing steps & medium exchange in large-scale microcarrier culture. Vaccine 24, pp. 3261 - 3272 (2006)
  3. Genzel, Y.; Olmer, R. M.; Schäfer, B.; Reichl, U.: Wave microcarrier cultivation of MDCK cells for influenza virus production in serum containing and serum-free media. Vaccine 24 (35-36), pp. 6074 - 6087 (2006)
  4. Heßeler, J.; Schmidt, J. K.; Reichl, U.; Flockerzi, D.: Coexistence in the Chemostat as a result of metabolic by-products. Journal of mathematical biology 53 (4), pp. 556 - 584 (2006)
  5. Kalbfuss, B.; Reichl, U.: Preparative Size-Exclusion Chromatography. GIT Laboratory Journal Europe 10 (4), pp. 18 - 20 (2006)
  6. Ritter, J. B.; Genzel, Y.; Reichl, U.: High-performance anion-exchange chromatography using on-line electrolytic eluent generation for the determination of more than 25 intermediates from energy metabolism of mammalian cells in culture. Journal of Chromatography B 843 (2), pp. 216 - 226 (2006)
  7. Schmidt, J. K.; König, B.; Reichl, U.: Characterization of a Three Bacteria Mixed Culture in a Chemostat: Evaluation and Application of a Quantitative Terminal-Restriction Fragment Polymorphism (T-RFLP) Analysis for Absolute and Species Specific Cell Enumeration. Biotechnology and Bioengineering 96 (4), pp. 738 - 756 (2006)

Meeting Abstract (2)

  1. Sidorenko, Y.; Dauner, M.; Genzel, Y.; Reichl, U.: Metabolic Flux Analysis of MDCK Cells in Glutamine-Containing and Glutamine-Free Culture Media. In: Metabolic Engineering VI: Program, p. 102. Metabolic Engineering IV, Noordwijkerhout, The Netherlands, October 01, 2006 - October 05, 2006. (2006)
  2. Sidorenko, Y.; Schulze-Horsel, J.; Voigt, A.; Reichl, U.; Kienle, A.: Stochastic Population Balance Modeling of Influenza Virus replication in a Vaccine Production Process. In: Conference Proceedings / AIChE annual meeting 2006, p. 622f. AIChE annual meeting 2006, San Francisco, USA, November 12, 2006 - November 17, 2006. (2006)

Talk (20)

  1. Genzel, Y.; Kalbfuss, B.; Ritter, J. B.; Schulze-Horsel, J.; Rapp, E.; Vester, D.; Reichl, U.: Characterization and analytical issues on an influenza A virus production process. Vaccines : Quality control, scale-up and manufacture, Hamburg, Germany (2006)
  2. Genzel, Y.; Sandig, V.; Jordan, I.: Neue Zellsubstrate und Einfluss von Medien und Prozessführung in der Impfstoffproduktion. 24. DECHEMA-Jahrestagung der Biotechnologen, Wiesbaden, Germany (2006)
  3. Genzel, Y.; Reichl, U.: Production of vaccines based on animal cell technology. Production of Biopharmaceuticals in Animal Cell Cultures, Rio de Janeiro, Brazil (2006)
  4. Genzel, Y.; Schulze-Horsel, J.; Reichl, U.: High Cell Density Microcarrier Process in a Wave Bioreactor for the Production of Influenza A Virus. Vaccine Technology, Puerto Vallarta, Mexiko (2006)
  5. Genzel, Y.; Reichl, U.: Limits and benefits of the interpretation of extracellular metabolite data in mammalian cell culture. 1st Max Planck Workshop on "Metabolomics", Magdeburg, Germany (2006)
  6. Kalbfuss, B.; Wolff, M. W.; Genzel, Y.; Zimmermann, A.; Morenweiser, R.; Reichl, U.: Chromatography-based purification of influenza A virus for the production of human whole-virion vaccines. ISPPP 2006 : 26th International Symposium on the Separation of Proteins, Peptides and Polynucleotides, Innsbruck, Austria (2006)
  7. Kalbfuss, B.; Wolff, M. W.; Geisler, L.; Thom, V.; Reichl, U.: Konzentrierung und Aufreinigung von Influenza Viren mittels Ionenaustauscher-Membranen. 24. DECHEMA-Jahrestagung der Biotechnologen, Wiesbaden, Germany (2006)
  8. Kalbfuss, B.; Gedicke, K.; Seidel-Morgenstern, A.; Reichl, U.: Maximizing productivity in size-exclusion chromatography of influenza virus: A modelling approach. ESBES 6 : 6th European Symposium on Biochemical Engineering Science, Salzburg, Austria (2006)
  9. Kalbfuss, B.; Wolff, M. W.; Genzel, Y.; Zimmermann, A.; Best, C.; Morenweiser, R.; Reichl, U.: A generic purification scheme for the production of human influenza vaccines derived from serum-free mammalian cell culture. Vaccine Technology, Puerto Vallarta, Mexico (2006)
  10. Reichl, U.: MDCK Cell Derived Influenza Vaccines: Aspects of Up- and Downstream Processing. Meeting Academy of Science, Sofia, Bulgarien (2006)
  11. Reichl, U.: Dynamics of Influenza Virus Replication in Mammalian Cell Culture. CCEX Workshop, Vancouver, Canada (2006)
  12. Reichl, U.: MDCK Cell derived Influenza Vaccines: Aspects of Modeling and Experimental Design in Upstream Processing. Meeting at Sanof Pasteur, Toronto, Canada (2006)
  13. Reichl, U.: Biological Fundamentals, Models and Technologies for Vaccine Production. Perspectives of Research - Identification and Implementation of Research Topics by Organizations : Ringberg-Symposium Mai 2006, Kreuth, Germany (2006)
  14. Reichl, U.: Mathematical Models for Mammalian Cell Growth and Virus Replication for an Influenza Vaccine Production Process. Technische Universität Berlin : Meeting, Berlin, Germany (2006)
  15. Ritter, J. B.; Genzel, Y.; Reichl, U.: Monitoring Energy Metabolism: The Challenge of Intracellular Metabolite Analysis of Mammalian Cells in Culture. 1st Max Planck Workshop on "Metabolomics", Magdeburg, Germany (2006)
  16. Schulze-Horsel, J.; Bock, A.; Genzel, Y.; Reichl, U.: Mammalian cell culture for influenza vaccine production: physiology during cell growth and virus propagation phase. GVC/DECHEMA-Jahrestagungen 2006 mit 24. DECHEMA-Jahrestagung der Biotechnologen, Wiesbaden, Germany (2006)
  17. Wahl, A.; Nöh, K.; Wiechert, W.: Metabolic and Isotopic Instationary Experiments: A Simulative Study. Metabolic Engineering VI, Noordwijkerhout, The Netherlands (2006)
  18. Wahl, S. A.; Nöh, K.; Wiechert, W.: Experiments at Metabolic and Isotopic Instationary State: An Exploratory study. Metabolic Engineering VI : From recDNA Towards Engineering Biological Systems, Noordwijkerhout, Netherlands (2006)
  19. Wolff, M. W.; Kalbfuss, B.; Opitz, L.; Zimmermann, A.; Lehmann, S.; Reichl, U.: Downstream Process of Influenza Viruses. European BioPharm Scale-Up Congress 2006, Geneva, Switzerland (2006)
  20. Wolff, M. W.; Kalbfuss, B.; Lehmann, S.; Morenweiser, R.; Opitz, L.; Zimmermann, A.; Reichl, U.: Downstream Processes and Glycan Characterization of MDCK-Cell Derived Influenza Virus. BioProcess Technology - Asia, Singapore (2006)

Poster (10)

  1. Bock, A.; Vejrazka, C.; Genzel, Y.; Reichl, U.: Perfusion system in high-density cell culture for higher yields in vaccine production. 24. DECHEMA-Jahrestagung der Biotechnologen, Wiesbaden, Germany (2006)
  2. Bock, A.; Schulze-Horsel, J.; Reichl, U.: Correlation of specific oxygen uptake rates and cell cycle duration of adherent mammalian cells in a large-scale microcarrier system. 6th European Symposium on Biochemical Engineering Science : ESBES 6, Salzburg, Austria (2006)
  3. Opitz, L.; Wolff, M. W.; Salaklang, J.; Rapp, E.; Reichl, U.: Lektin-Affinitätschromatographie zur Aufreinigung humaner Influenza Viren. GVC/DECHEMA-Jahrestagungen 2006, Wiesbaden, Germany (2006)
  4. Opitz, L.; Wolff, M. W.; Salaklang, J.; Rapp, E.; Reichl, U.: Lectin-affinity purification of cell culture derived human Influenza A viruses. ESBES 6 : 6th European Symposium on Biochemical Engineering Science, Salzburg, Austria (2006)
  5. Opitz, L.; Wolff, M. W.; Salaklang, J.; Rapp, E.; Kalbfuss, B.; Reichl, U.: Lectin-affinity purification of cell culture derived human Influenza A viruses. Vaccine Technology 2006, Puerto Vallarta, Mexico (2006)
  6. Ritter, J. B.; Genzel, Y.; Reichl, U.: Die Herausforderung der Analyse von intrazellulären Metaboliten in Säugerzellen. 24. DECHEMA-Jahrestagung der Biotechnologen, Wiesbaden, Germany (2006)
  7. Ritter, J. B.; Genzel, Y.; Reichl, U.: Monitoring Energy Metabolism: The Challenge of Intracellular Metabolite Analysis of Mammalian Cells in Culture. Cell Culture Engineering X, Whistler, Canada (2006)
  8. Schwarzer, J.; Rapp, E.; Schmidt, J. K.; Reichl, U.: Glycosylation of Influenza A Virus Hemagglutinin. 6th European Symposium on Biochemical Engineering Science (ESBES), Salzburg, Austria (2006)
  9. Vester, D.; Bettenbrock, K.; Schlawin, N.; Genzel, Y.: Real-Time PCR for quantitative analysis of human influenza A virus in infected mammalian cells. GVC/DECHEMA-Jahrestagungen 2006, Wiesbaden, Germany (2006)
  10. Vester, D.; Best, C.; Genzel, Y.; Gade, D.; Reichl, U.: Analysis of cellular metabolism and influenza viral replication of three human cell lines as candidates for proteomics. ESBES 6 : 6th European Symposium on Biochemical Engineering Science, Salzburg, Austria (2006)

Thesis - Dissertation (1)

  1. Möhler, L.: Segregierte mathematische Modelle zum Wachstum adhärenter tierischer Zellen (MDCK) und zur Influenza Virus Replikation. Dissertation, 142 pp., Shaker, Aachen (2006)

Thesis - Diploma (2)

  1. Deshpande, K.: Quantification of Influenza Virus Hemagglutinin (HA) by Reversed Phase - High pressure Liquid Chromatography (RP-HPLC) method. Diploma (2006)
  2. Salaklang, J.: Development of a Lectin-Affinity Chromatography for the Downstream Processing of Influenza A Virus Vaccines. Diploma (2006)
 
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