Journal Article (338)

2012
Journal Article
Selman, M. H. J.; Hoffmann, M.; Zauner, G.; McDonnell, L. A.; Balog, C. I. A.; Rapp, E.; Deelder, A. M.; Wuhrer, M.: MALDI-TOF-MS analysis of sialylated glycans and glycopeptides using 4-chloro-α-cyanocinnamic acid matrix. Proteomics 12 (9), pp. 1337 - 1348 (2012)
Journal Article
Zauner, G.; Hoffmann, M.; Rapp, E.; Koeleman, C. A. M.; Dragan, I.; Deelder, A. M.; Wuhrer, M.; Hensbergen, P. J.: Glycoproteomic Analysis of Human Fibrinogen Reveals Novel Regions of O‑Glycosylation. Journal of Proteome Research 11 (12), pp. 5804 - 5814 (2012)
2011
Journal Article
Bock, A.; Schulze-Horsel, J.; Schwarzer, J.; Rapp, E.; Genzel, Y.; Reichl, U.: High-density microcarrier cell cultures for influenza virus production. Biotechnology Progress 27 (1), pp. 241 - 250 (2011)
Journal Article
Frensing, T.; Seitz, C.; Heynisch, B.; Patzina, C.; Kochs, G.; Reichl, U.: Efficient influenza B virus propagation due to deficient interferon-induced antiviral activity in MDCK cells. Vaccine 29 (41), pp. 7125 - 7129 (2011)
Journal Article
Janke, R.; Genzel, Y.; Händel, N.; Wahl, A.; Reichl, U.: Metabolic adaptation of MDCK cells to different growth conditions: Effects on catalytic activities of central metabolic enzymes. Biotechnology and Bioengineering 108 (11), pp. 2691 - 2704 (2011)
Journal Article
Kalmbach, A.; Bordas, R.; Öncül, A.; Thévenin, D.; Genzel, Y.; Reichl, U.: Experimental Characterization of Flow Conditions in 2- and 20-L Bioreactors with Wave-Induced Motion. Biotechnology Progress 27 (2), pp. 402 - 409 (2011)
Journal Article
Kolvenbach, B. A.; Lenz, M.; Benndorf, D.; Rapp, E.; Fousek, J.; Vlcek, C.; Schäffer, A.; Gabriel, F. L.; Kohler, H.-P. E.; Corvini, P. F.: Purification and characterization of hydroquinone dioxygenase from Sphingomonas sp. strain TTNP3. AMB Express 1, p. 8 (2011)
Journal Article
Kuhn, R.; Benndorf, D.; Rapp, E.; Reichl, U.; Palese, L.; Pollice, A.: Metaproteome analysis of sewage sludge from membrane bioreactors. Proteomics 11 (13), pp. 2738 - 2744 (2011)
Journal Article
Petiot, E.; Jacob, D.; Lanthier, S.; Lohr, V.; Ansorge, S.; Kamen, A. A.: Metabolic and Kinetic analyses of influenza production in perfusion HEK293 cell culture. BMC Biotechnology 11 (84), pp. 1 - 12 (2011)
Journal Article
Popov, M.; Petrov, S. A.; Nacheva, G.; Ivanov, I.; Reichl, U.: Effects of a recombinant gene expression on ColE1-like plasmid segregation in Escherichia coli. BMC Biotechnology 11 (1), p. 18 (2011)
Journal Article
Riedele, C.; Reichl, U.: Inter-Species Effects in Ceftazidime-Treated Mixed Culture of Pseudomonas aeruginosa, Burkholderia cepacia and Staphylococcus aureus – Analysis on the Single Species Level. Journal of Antimicrobial Chemotherapy 66 (1), pp. 138 - 145 (2011)
Journal Article
Rödig, J.; Rapp, E.; Djeljadini, S.; Lohr, V.; Genzel, Y.; Jordan, I.; Sandig, V.; Reichl, U.: Impact of Influenza Virus Adaptation Status on HA N-Glycosylation Patterns in Cell Culture-Based Vaccine Production. Journal of Carbohydrate Chemistry 30 (4-6), pp. 281 - 290 (2011)
Journal Article
Roedig, J.; Rapp, E.; Höper, D.; Genzel, Y.; Reichl, U.: Impact of Host Cell Line Adaptation on Quasispecies Composition and Glycosylation of Influenza A Virus Hemagglutinin. PLoS One 6 (12), p. e27989 (2011)
Journal Article
Schmidt, J. K.; Riedele, C.; Regestein, L.; Rausenberger, J.; Reichl, U.: A novel concept combining experimental and mathematical analysis for the identification of unknown interspecies effects in a mixed culture. Biotechnology and Bioengineering 108 (8), pp. 1900 - 1911 (2011)
Journal Article
Wolff, M.; Reichl, U.: Downstream processing of cell culture-derived virus particles. Expert Review of Vaccines 10 (10), pp. 1451 - 1475 (2011)
2010
Journal Article
Benndorf, D.; Jach, M.; Klamt, S.; Reichl, U.: Systembiologie-Ausbildung von Anfang an. Systembiologie.de (2), pp. 82 - 84 (2010)
Journal Article
Domann, P. J.; Akashi, S.; Barbas, C.; Huang, L.; Lau, W.; Legido-Quigley, C.; McClean, S.; Neusüß, C.; Perrett, D.; Quaglia, M. et al.; Rapp, E.; Smallshaw, L.; Smith, N. W.; Smyth, W. F.; Taylor, C. F.: Guidelines for reporting the use of capillary electrophoresis in proteomics. Nature biotechnology 28 (7), pp. 654 - 655 (2010)
Journal Article
Genzel, Y.; Dietzsch, C.; Rapp, E.; Schwarzer, J.; Reichl, U.: MDCK and Vero cells for influenza virus vaccine production: a one-to-one comparison up to lab-scale bioreactor cultivation. Applied Microbiology and Biotechnology 88 (2), pp. 461 - 475 (2010)
Journal Article
Heynisch, B.; Frensing, T.; Heinze, K.; Seitz, C.; Genzel, Y.; Reichl, U.: Differential activation of host cell signaling pathways through infection with two variants of influenza A /Puerto Rico /8/34 (H1N1) in MDCK cells. Vaccine 28 (51), pp. 8210 - 8218 (2010)
Journal Article
Janke, R.; Genzel, Y.; Freund, S.; Wolff, M. W.; Grammel, H.; Rühmkorf, C.; Seidemann, J.; Wahl, A.; Reichl, U.: Expression, purification, and characterization of a His6-tagged glycerokinase from Pichia farinosa for enzymatic cycling assays in mammalian cells. Journal of Biotechnology 150 (3), pp. 396 - 403 (2010)
Journal Article
Janke, R.; Genzel, Y.; Wahl, A.; Reichl, U.: Measurement of Key Metabolic Enzyme Activities in Mammalian Cells Using Rapid and Sensitive Microplate-Based Assays. Biotechnology and Bioengineering 107 (3), pp. 566 - 581 (2010)
Journal Article
Kröber, T.; Knöchlein, A.; Eisold, K.; Kalbfuß-Zimmermann, B.; Reichl, U.: DNA Depletion by Precipitation in the Purification of Cell Culture-Derived Influenza Vaccines. Chemical Engineering and Technology 33 (6), pp. 941 - 959 (2010)
Journal Article
Lohr, V.; Genzel, Y.; Behrendt, I.; Scharfenberg, K.; Reichl, U.: A new MDCK suspension line cultivated in a fully defined medium in stirred-tank and wave bioreactor. Vaccine 28 (38), pp. 6256 - 6264 (2010)
Journal Article
Öncül, A.; Kalmbach, A.; Genzel, Y.; Reichl, U.; Thevenin, D.: Characterization of flow conditions in 2 L and 20 L wave bioreactors using Computational Fluid Dynamics. Biotechnology Progress 26 (1), pp. 101 - 110 (2010)
Journal Article
Ritter, J.; Wahl, A.; Freund, S.; Genzel, Y.; Reichl, U.: Metabolic effects of influenza virus infection in cultured animal cells: Intra- and extracellular metabolite profiling. BMC Systems Biology 4, p. 61 (2010)
Journal Article
Rollié, S.; Lendeckel, U.; Naumann, M.; Reichl, U.; Sundmacher, K.: Dynamics of bionanoparticle targeting in mixtures of human tumour cells by validated population balance modelling. Soft Matter 6 (6), pp. 1203 - 1216 (2010)
Journal Article
Roma-Rodriguesa, C.; Santosa, P.; Benndorf, D.; Rapp, E.; Sá-Correiaa, I.: Response of Pseudomonas putida KT2440 to phenol at the level of membrane proteome. Proteomics 73 (8), pp. 1461 - 1478 (2010)
Journal Article
Ruhaak, L.E.; Hennig, R.; Huhn, C.; Borowiak, M.; Dolhain, R.J.E.M.; Deelder, A.; Rapp, E.; Wuhrer, M.: Optimized Workflow for Preparation of APTS-Labeled N-Glycans Allowing High-Throughput Analysis of Human Plasma Glycomes using 48-Channel Multiplexed CGE-LIF. Journal of Proteome Research 9 (12), pp. 6655 - 6664 (2010)
Journal Article
Seitz, C.; Frensing, T.; Höper, D.; Kochs, G.; Reichl, U.: High yields of Influenza A virus in MDCK cells are promoted by an insufficient IFN-induced antiviral state. Journal of General Virology 91 (7), pp. 1754 - 1763 (2010)
Journal Article
Vester, D.; Pflugmacher, A.; Hoffmann, D.; Seitz, C.; Heldt, S.; Bettenbrock, K.; Genzel, Y.; Reichl, U.: Real-time RT-qPCR assay for the analysis of human influenza A virus transcription and replication dynamics. Journal of Virological Methods 168 (1-2), pp. 63 - 71 (2010)
Journal Article
Vester, D.; Rapp, E.; Kluge, S.; Genzel, Y.; Reichl, U.: Virus-host cell interactions in vaccine production cell lines infected with different human influenza A virus variants: A proteomic approach. Journal of Proteomics 73 (9), pp. 1656 - 1669 (2010)
Journal Article
Wolff, M.; Siewert, C.; Hansen, S. P.; Faber, R.; Reichl, U.: Purification of cell culture-derived modified Vaccinia Ankara virus by pseudo-affinity membrane adsorbers and hydrophobic interaction chromatography. Biotechnology and Bioengineering 107 (2), pp. 312 - 320 (2010)
Journal Article
Wolff, M.; Siewert, C.; Lehmann, S.; Hansen, S.P.; Djurup, R.; Faber, R.; Reichl, U.: Capturing of Cell Culture-Derived Modified Vaccinia Ankara Virus by Ion Exchange and Pseudo-Affinity Membrane Adsorbers. Biotechnology and Bioengineering 105 (4), pp. 761 - 769 (2010)
2009
Journal Article
Bock, A.; Möhler, L.; Sann, H.; Schulze-Horsel, J.; Genzel, Y.; Reichl, U.: Growth behaviour of number distributed adherent MDCK cells for optimization in large scale microcarrier cultures. Biotechnology Progress 25 (6), pp. 1717 - 1731 (2009)
Journal Article
Genzel, Y.; Reichl, U.: Continuous cell lines as production system for influenza vaccines. Expert Review of Vaccines 8 (12), pp. 1681 - 1692 (2009)
Journal Article
Lohr, V.; Rath, A.; Genzel, Y.; Jordan, I.; Sandig, V.; Reichl, U.: New avian suspension cell lines provide production of influenza virus and MVA in serum-free media: studies on growth, metabolism and virus propagation. Vaccine 27 (36), pp. 4975 - 4982 (2009)
Journal Article
Opitz, L.; Hohlweg, J.; Reichl, U.; Wolff, M. W.: Purification of cell culture-derived influenza virus A/Puerto Rico/8/34 by membrane-based immobilized metal affinity chromatography. Journal of Virological Methods 161 (2), pp. 312 - 316 (2009)
Journal Article
Opitz, L.; Lehmann, S.; Reichl, U.; Wolff, M. W.: Sulfated membrane adsorbers for economic pseudo-affinity capture of influenza virus particles. Biotechnology and Bioengineering 103 (6), pp. 1144 - 1154 (2009)
Journal Article
Rapp, E.; Charvat, A.; Beinsen, A.; Plessmann, U.; Reichl, U.; Seidel-Morgenstern, A.; Urlaub, H.; Abel, B.: Atmospheric Pressure Free Liquid Infrared MALDI Mass Spectrometry: Toward a combined ESI/MALDI-Liquid Chromatography Interface. Analytical Chemistry 81 (1), pp. 443 - 452 (2009)
Journal Article
Schulze-Horsel, J.; Schulze, M.; Agalaridis, G.; Genzel, Y.; Reichl, U.: Infection dynamics and virus-induced apoptosis in cell culture-based influenza vaccine production – flow cytometry and mathematical modeling. Vaccine 27 (20), pp. 2712 - 2722 (2009)
Journal Article
Schwarzer, J.; Rapp, E.; Hennig, R.; Genzel, Y.; Jordan, I.; Sandig, V.; Reichl, U.: Glycan analysis in cell culture-based influenza vaccine production: Influence of host cell line and virus strain on the glycosylation pattern of viral hemagglutinin. Vaccine 27 (32), pp. 4325 - 4336 (2009)
Journal Article
Vester, D.; Rapp, E.; Gade, D.; Genzel, Y.; Reichl, U.: Quantitative analysis of cellular proteome alterations in human influenza A virus-infected mammalian cell lines. Proteomics 9 (12), pp. 3316 - 3327 (2009)
2008
Journal Article
Antoniukas, L.; Grammel, H.; Sasnauskas, K.; Reichl, U.: Profiling of external metabolites during production of hantavirus nucleocapsid protein with recombinant Saccharomyces cerevisiae. Biotechnology Letters 30 (3), pp. 415 - 420 (2008)
Journal Article
Kalbfuss, B.; Flockerzi, D.; Seidel-Morgenstern, A.; Reichl, U.: Size-exclusion chromatography as a linear transfer system: Purification of human influenza virus as an example. Journal of Chromatography B 873 (1), pp. 102 - 112 (2008)
Journal Article
Kalbfuss, B.; Knöchlein, A.; Kröber, T.; Reichl, U.: Monitoring Influenza Virus Content in Vaccine Production: Precise Assays for the Quantitation of Hemagglutination and Neuraminidase Activity. Biologicals 36 (3), pp. 145 - 161 (2008)
Journal Article
Möhler, L.; Bock, A.; Reichl, U.: Segregated Mathematical Model for Growth of Anchorage-Dependent MDCK Cells in Microcarrier Culture. Biotechnology Progress 24 (1), pp. 110 - 119 (2008)
Journal Article
Opitz, L.; Zimmermann, A.; Lehmann, S.; Genzel, Y.; Lübben, H.; Reichl, U.; Wolff, M. W.: Capture of cell culture-derived influenza virus by lectins: strain independent, but host cell dependent. Journal of Virological Methods 154 (1-2), pp. 61 - 68 (2008)
Journal Article
Pohlscheidt, M.; Kauling, D. J.; Havekost, D.; Bödeker, B.; Langer, U.; Apeler, H.; Hörlein, H. D.; Rübsamen-Waigmann, H.; Reichl, U.; Henzler, H. J.: Auslegungsunterlagen für Bioreaktoren zur Maßstabsvergrößerung eines microcarrierbasierenden Virusproduktionsprozesses. Chemie-Ingenieur-Technik 80 (6), pp. 821 - 830 (2008)
Journal Article
Ritter, J. B.; Genzel, Y.; Reichl, U.: Simultaneous extraction of several metabolites of energy metabolism and related substances in mammalian cells: Optimization using experimental design. Analytical Biochemistry 373, pp. 349 - 369 (2008)
Journal Article
Schulze-Horsel, J.; Genzel, Y.; Reichl, U.: Flow cytometric monitoring of influenza A virus infection in MDCK cells during vaccine production. BMC Biotechnology 8, p. 45 (2008)
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