Ausgewählte Artikel

Hier stellen wir Ihnen ausgewählte Artikel, Publikationen und Bücher vor, die von Wissenschaftlerinnen und Wissenschaftlern des MPI Magdeburg veröffentlicht wurden.

2023

Editor’s Choice Paper in metabolites

Impact of Influenza A Virus Infection on Growth and Metabolism of Suspension MDCK Cells Using a Dynamic Model

Rodrigues Correia Ramos, J.; Bissinger, T.; Genzel, Y.; Reichl, U.: Impact of Influenza A Virus Infection on Growth and Metabolism of Suspension MDCK Cells Using a Dynamic Model. Metabolites 12 (3), 239 (2022)

 

2022

Integrated Chemical Processes in Liquid Multiphase Systems

From Chemical Reaction to Process Design and Operation

Zum Abschluss des Sonderforschungsbereiches Transregio 63 InPROMPT: Integrierte Chemische Prozesse in flüssigen Mehrphasensystemen ist im Juni 2022 ein Buch erschienen, in dem die Ergebnisse des Forschungsverbundes zusammengefasst werden.

Im Rahmen des Sonderforschungsbereiches Transregio 63 InPROMPT: Integrierte Chemische Prozesse in flüssigen Mehrphasensystemen haben sie das Ziel verfolgt, grüne, chemische Produktionsprozesse zu entwickeln. Nachwachsende Rohstoffe für die Herstellung vieler chemischer Produkte sollen dabei Erdöl und Erdgas langfristig zu ersetzen.

Das Projekt zeichnet sich durch das enge Zusammenspiel von Experiment, Modellierung und Optimierung, ein breites Spektrum homogen katalysierter Reaktionen und einer allgemeinen Methodik für eine schnelle modellbasierte Prozessentwicklung aus.

Kraume, M.; Enders, S.; Drews, A.; Schomäcker, R.; Engell, S.; Sundmacher, K. (Hg.): Integrated Chemical Processes in Liquid Multiphase Systems: from Chemical Reaction to Process Design and Operation. De Gruyter, Berlin/Boston (2022), 622 S.

 

 

Realization and Model Reduction of Dynamical Systems

A Festschrift in Honor of the 70th Birthday of Thanos Antoulas

Prof. Antoulas is renowned for his fundamental research contributions. This Festschrift is being published for a conference to celebrate Antoulas's 70th birthday. Model reduction is a timely and important area with many scientific and engineering applications.
This book celebrates Professor Thanos Antoulas's 70th birthday, marking his fundamental contributions to systems and control theory, especially model reduction and, more recently, data-driven modeling and system identification. Model reduction is a prominent research topic with wide ranging scientific and engineering applications. 

Beattie, C.; Benner, P.; Embree, M.; Gugercin, S.; Lefteriu, S. (Hg.): Realization and Model Reduction of Dynamical Systems. Springer International Publishing, Cham (2022), XIX, 460 S.

2021

Light-Powered Reactivation of Flagella and Contraction of Microtubule Networks: Toward Building an Artificial Cell

About the Cover: Integration of light-switchable functionalized vesicles with demembranated flagella. Upon illumination, Bacteriorhodopsin pumps a proton into the vesicle's interior, establishing a proton motive force that drives ATP synthase to catalyze the conversion of ADP to ATP. ATP is consumed by dynein molecular motors, generating active forces for flagellar beating.

Ahmad, R.; Kleineberg, C.; Nasirimarekani, V.; Su, Y.-J.; Goli Pozveh, S.; Bae, A.; Sundmacher, K.; Bodenschatz, E.; Guido, I.; Vidaković-Koch, T. et al.; Gholami, A.: Light-Powered Reactivation of Flagella and Contraction of Microtubule Networks: Toward Building an Artificial Cell. ACS Synthetic Biology 10 (6), S. 1490 - 1504 (2021)

2020

Cover Feature: Light-Driven ATP Regeneration in Diblock/Grafted Hybrid Vesicles (ChemBioChem 15/2020)

A light-driven ATP regeneration module has been created through bottom-up assembly of small building blocks such as proteins, lipids and polymers. The use of polymer hybrid compartments instead of conventional liposomes significantly increased the long-term stability of the module. This could play an important role especially when using the module as an energy supply to drive cell-like functions within artificially created reaction compartments like protocells. More information can be found in the full paper by Tanja Vidaković-Koch et al.

Kleineberg, C.; Wölfer, C.; Abbasnia, A.; Pischel, D.; Bednarz, C.; Ivanov, I.; Heitkamp, T.; Börsch, M.; Sundmacher, K.; Vidaković-Koch, T.: Light-Driven ATP Regeneration in Diblock/Grafted Hybrid Vesicles. ChemBioChem 21 (15), S. 2149 - 2160 (2020)

Speeding up Viedma Deracemization through Water‐catalyzed and Reactant Self‐catalyzed Racemization

The Cover Feature in ChemPhysChem, Volume 21, Issue 16, August 18, 2020, summarizes the results of a joint computational and experimental study demonstrating that faster racemization through water‐catalyzed enolization could result in faster deracemization of a scalemic slurry of a chiral hydrazine derivative.

This paper has been published with the project partners at Friedrich-Alexander University of Erlangen-Nürnberg as part of the CORE ITN Project by the European Union Horizon 2020 Research and Innovation Program.

 

Tortora, C.; Mai, C.; Cascella, F.; Mauksch, M.; Seidel-Morgenstern, A.; Lorenz, H.; Tsogoeva, S. B.: Speeding up Viedma Deracemization through Water catalyzed and Reactant Self‐catalyzed Racemization. ChemPhysChem 21 (16), S. 1775 - 1787 (2020)

 


Preparative Chromatography

The third edition of this popular work is revised to include the latest developments in this fast-changing field. Its interdisciplinary approach elegantly combines the chemistry and engineering to explore the fundamentals and optimization processes involved.

Summary

The book starts with a short history of chromatography and outlines future developments. The focus is preparative chromatography i.e. to isolate and purify products in high quality and yield by optimal and cost‐effective processes. It is the aim to provide and develop access to chromatographic purification concepts through the eyes of both engineers and chemists. This includes the fundamentals of natural science and design of materials and functionalities as well as mathematical modeling, simulation and process design supplemented by process operation and plant design.

"This special volume is essential for chemists and engineers working in chemical and pharmaceutical industries, as well as for food technologies, due to the interdisciplinary nature of these preparative chromatographic processes." Advances in Food Sciences

Schmidt-Traub, H.; Schulte, M.; Seidel-Morgenstern, A. (Hg.): Preparative Chromatography. Wiley-VCH Verlag, Weinheim (2020), 609 S.

 


 

Purification of Curcumin from Ternary Extract-Similar Mixtures of Curcuminoids in a Single Crystallization Step

Highlight on the Front Cover of Crystals 2020, 10(3), 206; https://doi.org/10.3390/cryst10030206

Curcumin and its derivatives demethoxycurcumin (DMC) and bis(demethoxy)curcumin (BDMC) are natural ingredients of the plant rhizome of Curcuma longa L. Together they are known as curcuminoids. Despite their strong similarity in molecular structure, their pharmacological activity and therapeutic effects can differ, which requires isolation of curcumin in pure state. In the article, crystallization-based separation of curcumin from extract-similar curcuminoid mixtures is studied. Based on solubility and supersolubility data of pure curcumin and curcumin in the initial mixture, seeded cooling crystallization procedures were derived using different solvents/solvent systems. As a result, crystalline curcumin of up to 99.4% purity, free of BDMC and depleted DMC content, was provided in a simple single crystallization step. Opportunities to further enhance total curcumin recovery by optimizing the crystallization strategy are highlighted.
 
Horosanskaia, E.; Yuan, L.; Seidel-Morgenstern, A.; Lorenz, H.: Purification of Curcumin from Ternary Extract-Similar Mixtures of Curcuminoids in a Single Crystallization Step. Crystals 10 (3), 206 (2020)
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