Chiral molecules differ in the stereochemistry of ONE atom (stereocentre). The two forms of the entity may have identical physical properties but behave differently under physiological conditions. The separation of chiral forms of a molecule (enantiomers) is thus of fundamental importance to the chemical and pharmaceutical idustry.
We investigate the separation of enantiomers by
- liquid phase extraction
- formation of diastereomeric complexes
- enantioselective crystallization.
The detailed understanding of the behaviour of chiral molecules in different phases requires an accurate description of the respective binding affinities and solute-solvent interactions. It is our aim to rationalize processes that lead to enantiopure entities and design specific receptors.